Synopsis
Are you searching for stories to ignite your curiosity, teach you to perform better in life and career, inspire your mind, and make you laugh along the way? In this science podcast, Dr. Marie McNeely introduces you to the brilliant researchers behind the latest discoveries in science. Join us as they share their greatest failures, most staggering successes, candid career advice, and what drives them forward in life and science.
Episodes
-
730: Using Chemical Biology to Clarify the Roles of Carbohydrates - Dr. Laura Kiessling
16/10/2023 Duration: 43minDr. Laura Kiessling is the Novartis Professor of Chemistry at Massachusetts Institute of Technology (MIT) and Member of the Broad Institute. Laura’s research focuses on carbohydrates, particularly all of the different carbohydrates found on the surfaces of cells. We still know relatively little about the functions of these carbohydrates, and Laura is eager to learn more. When she’s not doing science, Laura likes being active through rowing, kayaking, cycling, lifting weights, or doing yoga. She also likes to spend her free time cooking, hiking, camping, and enjoying art. She received her BS degree in chemistry from MIT and her Ph.D. degree in organic chemistry from Yale University. After two years at the California Institute of Technology as an American Cancer Society Postdoctoral Fellow, she joined the faculty of the University of Wisconsin, Madison in 1991. She returned to MIT in 2017. Laura has received numerous awards over the course of her career, including the Ronald Breslow Award in Biomimetic Chemistr
-
729: Studying Synaptic Plasticity to Understand How the Brain Learns and Adapts - Dr. Nicole Calakos
09/10/2023 Duration: 44minDr. Nicole Calakos is the Lincoln Financial Group Distinguished Professor of Neurobiology and Chief of the Movement Disorders section in Neurology at Duke University Medical Center. Research in Nicole’s lab examines how the brain learns and adapts to experiences. She studies synaptic plasticity, from the levels of molecules, cells, cell circuits, and behaviors, to understand what goes wrong in disease and how we can harness brain processes to address disease. When she’s not working, Nicole enjoys being outdoors, playing sports, running, going mountain biking, and participating in mountain bike races. Her favorite indoor activities include creative cooking and spending time with family and friends. Nicole was awarded her MD and PhD degrees from Stanford University. Afterwards, she completed an internship in Medicine and Residency in Neurology at the University of California, San Francisco School of Medicine. She conducted postdoctoral research at Stanford University before joining the faculty at Duke Universit
-
728: Researching Risk Factors and Therapies for Blood Clots in the Lungs and Legs - Dr. Alex Spyropoulos
02/10/2023 Duration: 40minDr. Alex Spyropoulos (“Dr. Spy”) is a Professor of Medicine at the Hofstra Northwell School of Medicine as well as System Director of Anticoagulation and Clinical Thrombosis Services for the multi-hospital Northwell Health System. In addition, Dr. Spy is a Professor of the Merinoff Center for Patient-Oriented Research as part of the Feinstein Institute for Medical Research. As a thrombologist, Dr. Spy studies blood clots. Many people worldwide are either at risk for blood clots or have existing clots. He focuses on venous thromboembolism primarily in the lungs and legs. These blood clots could cause morbidity or mortality, and many people are not familiar with the risks, common symptoms, or the situations in which clots may occur. Outside of work, Dr. Spy loves spending time with his wife and his young kids. Lately, they’ve been enjoying apple picking, hay rides, pumpkin carving, and apple carving. His other hobbies include sailing, snowboarding and mountain biking. He received his MD from the University of P
-
727: Investigating Insidious Insects in the Field of Agricultural Pest Management - Dr. Erin Hodgson
25/09/2023 Duration: 42minDr. Erin Hodgson is an Associate Professor and Extension Entomologist at Iowa State University. She specializes in insects in agriculture, often focusing on corn and soybean crops. Erin also works with people like farmers, crop consultants, people in the agricultural industry, regulators, and people in pest management to best manage insect pests in an agricultural landscape. Erin spends her free time outside enjoying the company of her husband and two dogs. She is also an Assistant Coach for the Iowa State University Women’s Rugby Club and dedicates a lot of her time in the evenings to helping coach the team. She received her undergraduate training in Biology and Botany and her M.S. in Entomology from North Dakota State University. Erin was awarded her Ph.D. in Entomology from the University of Minnesota, followed by a postdoctoral research position also at the University of Minnesota. Erin served on the faculty at Utah State University before joining the faculty at Iowa State where she is today. Erin has rec
-
726: Mechanical Engineer Making Miniature Mobile Robots - Dr. Sarah Bergbreiter
18/09/2023 Duration: 40minDr. Sarah Bergbreiter is an Associate Professor in the Department of Mechanical Engineering with a joint appointment in the Institute for Systems Research at the University of Maryland. Sarah’s research involves building and conducting experiments with tiny locomoting robots that are about the size of ants. They also apply the same technologies used in their tiny robots to build better sensors and actuators for bigger robots to help improve performance of these robots. Spending time with her family is a big part of Sarah’s life outside of work. Her kids enjoy swimming, playing with legos, and building things. Sarah also spends her free time swimming and playing water polo. She received her B.S.E. degree in electrical engineering from Princeton University and was awarded her M.S. and Ph.D degrees in electrical engineering from the University of California at Berkeley where she focused on microrobotics. Sarah has been the recipient of multiple awards for her outstanding work including the DARPA Young Faculty Aw
-
725: Improving How We Diagnose and Treat Certain Blood Clotting Conditions - Dr. Anand Padmanabhan
11/09/2023 Duration: 42minDr. Anand Padmanabhan is a pathologist, transfusion medicine physician, and Associate Professor of Laboratory Medicine and Pathology at the Mayo Clinic. Anand studies blood clotting, also known as “thrombosis”. He is working on a particular type of blood clotting that can occur when our bodies produce antibodies for proteins or other molecules inside or on the surface of blood platelets. Anand is interested both in finding better ways to diagnose and to treat patients with these potentially deadly diseases. When he’s not working, Anand loves spending time with his wife, their 15-year-old son, and their two dogs. They enjoy watching movies and traveling together across the U.S. and around the world. He received his Bachelor of Medicine, Bachelor of Surgery (M.B.B.S.) degree from Thanjavur Medical College and completed a Clinical Internship in Medicine and Surgery at LLR and Associated Hospitals in India. He was awarded his PhD in biochemistry from Brown University. Afterwards, Anand completed his residency in
-
724: Heading Up Research Designing New Materials for Helmets to Prevent Brain Injury - Dr. Ellen Arruda
04/09/2023 Duration: 39minDr. Ellen Arruda is the Maria Comninou Collegiate Professor of Mechanical Engineering with joint appointments as Professor of Biomedical Engineering, as well as Macromolecular Science and Engineering at the University of Michigan. Ellen studies the mechanical behavior of soft materials, including polymers, plastics, and soft tissues of the body. Her research group focuses on understanding how to design with soft materials so the materials don’t break in different applications, as well as how to design replacements for soft tissues in our bodies when they are damaged. Ellen’s hobbies include running, cooking, and knitting. Running is one of her favorite ways to get exercise and generate great ideas for her work. She is a skilled sweater knitter who learned how to crochet from her mother and picked up knitting from her mother-in-law. She received her B.S. with Honors in Engineering Science and her M.S. in Engineering Mechanics from Pennsylvania State University. Ellen was awarded her Ph.D. in Mechanical Enginee
-
723: Analyzing Complex Networks of Plant-Animal Interactions - Dr. John Kress
28/08/2023 Duration: 38minDr. John Kress is a Distinguished Scientist and Curator of Botany at the Smithsonian’s National Museum of Natural History. John’s research involves exploring the natural world and all the organisms that make up the natural world. Since graduate school, he has been exploring different areas, particularly tropical areas, to determine what grows there now, what grew there in the past, and how the plants and animals there interact. Not only does John enjoy investigating the natural world at work, he also enjoys spending his free time outside exploring nature. John often goes on walks or hikes with his wife and dog to see nature in action. In addition, John is an avid gardener. Among the plants he cultivates in his own yard are some of the ginger and banana plants that he studies. John received his B.A. in biology from Harvard University and his Ph.D. in botany from Duke University. John formerly served as the Interim Undersecretary for Science for the Smithsonian Institution, Executive Director of the Association
-
722: Taking Critical Steps to Elucidate Mechanisms of Limb Movement in Locomotion - Dr. Young-Hui Chang
21/08/2023 Duration: 41minDr. Young-Hui Chang is a Professor of Biological Sciences at Georgia Institute of Technology where he directs research in the Comparative Neuromechanics Laboratory. Research in Young-Hui’s lab aims to examine how the control of movement by the nervous system is influenced by mechanics and physics during locomotion. He is interested in broad mechanisms for behaviors like walking, running, and hopping that apply within and across species. Young-Hui likes to spend his free time with his family. He, his wife, and his two boys enjoy exploring the outdoors, hiking, and camping together. Though Young-Hui was not always a particularly outdoorsy person, enrolling his sons in the Scouts program has provided an avenue for him and his family to learn more and get outside. Young-Hui received his B.S. in Mechanical Engineering and his M.S. in Animal Physiology from Cornell University. Next, he conducted his doctoral studies at the University of California, Berkeley, earning his PhD in Integrative Biology in 2000. Prior to
-
721: Dr. Sonia Mayoral: Unraveling Mysteries Surrounding the Development and Function of Glial Cells
14/08/2023 Duration: 39minDr. Sonia Mayoral is the Robert J. and Nancy D. Carney Assistant Professor of Brain Science at Brown University. In the lab, Sonia studies glial cells, the cells in your brain that aren’t neurons. These cells perform a lot of different functions and could hold promise for developing therapies for neurologic diseases. Outside of work, Sonia loves spending as much time as possible with her four-year-old son. Lately, they’ve been enjoying playing Plants vs. Zombies on the iPad and also acting the game out around the house. She received her bachelor’s degree in biological sciences from San Jose State University and her PhD in neuroscience from Stanford University. Afterwards, she conducted postdoctoral research at the University of California, San Francisco. She joined the faculty at Brown University in 2021. In this interview, she shares more about her life and science.
-
720: Stimulating Research on the Mechanisms of Memory and Applications of Memory Modulation - Dr. Steve Ramirez
07/08/2023 Duration: 01h08minDr. Steve Ramirez is an Assistant Professor in the Department of Psychological and Brain Sciences at Boston University. In his research, Steve is studying learning and memory, and he is interested in discovering whether it is possible to artificially turn memories on and off. His research focuses on understanding the brain and what we can do when processes in the brain break down. They are working on turning on positive or negative memories in animal models to gain a better understanding of how the brain and memory work. In addition, they use animal models of conditions like depression, anxiety, and PTSD to study whether artificially manipulating memories may alleviate some of the symptoms of these conditions. Steve was born and raised in the Boston area, so accepting a faculty position at Boston University meant reuniting with his family, friends, and beloved New England Patriots. He spends his down time watching Netflix with friends and hanging out with his family. He attended Boston University for his unde
-
719: Studying the Sea through Shells, Skeletons, and Sediments - Dr. Abby Smith
31/07/2023 Duration: 39minDr. Abby Smith is an Associate Professor and Head of the Department of Marine Science at the University of Otago. In the lab, Abby is dedicated to studying shells and the animals that make shells. She is interested in how shells are made, what they are made out of, and how fast they grow. Abby also examines how shells break down over time and uses old shells to understand what the water was like in the past. Outside of science, Abby is a mother of two, and she keeps busy with family life and taking care of her kids. In her free time, she likes to watch cricket, knit, and cook. In particular, Abby has been experimenting lately with making different fruit jams and preserves. She Received her B.A. Degree in Geology and Biology from Colby College, her M.S. Degree in Earth, Atmospheric, and Planetary Sciences from the Massachusetts Institute of Technology, and her PhD in Earth Science from the University of Waikato. Abby joined us in this interview to share stories from her life and science.
-
718: Making Molecular Movies of Complex Chemical Reactions in Live Cells - Dr. Antoine van Oijen
24/07/2023 Duration: 42minDr. Antoine van Oijen is a Distinguished Professor and Australian Research Council Laureate Fellow in the School of Chemistry at the University of Wollongong in Australia. The work Antoine does combines physics, chemistry, and biology. He develops new types of microscopes to visualize complex biochemical reactions at the level of individual molecules. In particular, his group is interested in how DNA is copied before a cell divides. Antoine is also doing research examining how bacteria acquire antibiotic resistance. Antoine and his family enjoy spending much of their free time exploring the beautiful beach and hiking in the wonderful parks nearby. Antoine received his MSc and PhD in Physics from Leiden University in the Netherlands, where his graduate work was recognized with the C.J. Kok prize for best doctoral thesis. Afterwards, he conducted postdoctoral research in Chemistry and Chemical Biology at Harvard University. Antoine served on the faculty at Harvard Medical School and Groningen University in the
-
717: Developing Tools and Resources to Accelerate Neuroscience Discovery - Dr. Hongkui Zeng
17/07/2023 Duration: 42minDr. Hongkui Zeng is Executive Vice President and Director of the Allen Institute for Brain Science. She is dedicated to understanding how the brain is organized and how the different components of the brain work together to generate behaviors and functions. Hongkui and her colleagues examine the cellular basis of brain circuit formation and how those circuits produce function. They generate foundational tools and resources for the neuroscience community to help scientists around the world advance their research on neurological disease, potential treatments, and more. Living in the beautiful city of Seattle, Hongkui enjoys getting outside and exploring nature. This includes kayaking and hiking in the nearby mountains. When she’s at home, Hongkui likes to relax with a good book, listen to music, and indulge in watching shows and movies. She received her B.S. degree in biochemistry from Wuhan University and her PhD in molecular and cell biology from Brandeis University. Next, she conducted postdoctoral research
-
716: Metabolic-Based Therapies As a Key Component in Treating Cancer and Other Diseases - Dr. Dominic D'Agostino
10/07/2023 Duration: 55minDr. Dominic D’Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida. He is also a Research Scientist Institute for Human and Machine Cognition. Dom’s lab develops technology that allows them to investigate the molecular, cellular, and physiological changes we experience in extreme environments, including those that would occur undersea, at high altitude, or in space. They are also designing and evaluating metabolic-based therapies as treatments for cancer and other diseases. Dom and his wife enjoy outdoor activities like going to the beach, hiking, kayaking, mountain biking, and horseback riding. They also do quite a bit of scuba diving together for his wife’s marine biology research on manta rays. Data collection has taken them to Indonesia, Fiji, Palau, Hawaii, and many other phenomenal dive sites. Dom received his B.S. in Nutritional Sciences and Biological Sciences as well as his Ph.D. in Neuroscience and Physiology at Rutgers Univ
-
715: An Astrophysicist Studying the Elements of Galaxy Evolution - Dr. Molly Peeples
03/07/2023 Duration: 45minDr. Molly Peeples is an Aura Assistant Astronomer at the Space Telescope Science Institute in Baltimore, Maryland. Molly’s research is improving our understanding of galaxies and helping to reveal why galaxies are different from each other and how galaxies have changed over time. To do this, she traces the origins and fates of heavy elements that were all originally produced within stars. Examining where the elements end up gives us information on how gas flows into and out of galaxies. Molly also does modeling and runs simulations to better understand what is going on in the universe. There are a lot of great parks around Baltimore, so Molly likes getting outside to go hiking in her free time. She also enjoys cooking, reading, trying new cocktails, exploring new bars in town, and playing board games with friends. She received her B.S. in Physics from MIT and went on to complete her MS and PhD in Astronomy at Ohio State University. Molly was then awarded a Southern California Center for Galaxy Evolution Fello
-
714: Tiny Technology with Big Impacts: Nanoparticles for Medicine, Energy, and the Environment - Dr. Christy Haynes
26/06/2023 Duration: 47minDr. Christy Haynes is the Elmore H. Northey Professor of Chemistry at the University of Minnesota. In Christy’s research group, they are working to develop new methods to monitor small quantities of important chemicals in complex environments. Their research also aims to develop new, safe nanomaterials for applications in human health and sustainable energy. When she’s not at work, Christy loves to go for a run around the lakes of Minneapolis and spend time with her spouse and two kids. Her son has an analytic mind and is interested in competitive sports, while her daughter enjoys art and music. She completed her undergraduate studies in Chemistry at Macalester College and received her MS and PhD in Chemistry from Northwestern University. Next, Christy was awarded a National Institutes of Health National Research Service Award Post-Doctoral Fellowship to conduct research at the University of North Carolina, Chapel Hill. She joined the faculty at the University of Minnesota in 2005. Christy has received many a
-
713: Combining Chemistry and Biology to Develop New Research Tools and Therapeutics - Dr. David Liu
19/06/2023 Duration: 45minDr. David R. Liu is the Richard Merkin Professor and Director of the Merkin Institute of Transformative Technologies in Healthcare, vice-chair of the faculty at the Broad Institute of MIT and Harvard, the Thomas Dudley Cabot Professor of the Natural Sciences at Harvard University, and a Howard Hughes Medical Institute (HHMI) investigator. In addition, he is the founder or co-founder of several biotechnology and therapeutics companies, including Beam Therapeutics, Prime Medicine, Editas Medicine, Pairwise Plants, Exo Therapeutics, Chroma Medicine, Resonance Medicine, and Nvelop Therapeutics. David’s research integrates components of biological evolution with chemistry to enable the development of new types of therapeutics and to better study biology. Through chemistry, they can change the structure of a molecule in order to change its function in anticipated ways. They also harness the power of cycles of natural selection to evolve molecules with desired tailor-made properties. Outside of science, David’s hobb
-
712: Dr. Lynne Maquat: Understanding Cellular and Molecular Pathways that Contribute to Human Disease
12/06/2023 Duration: 42minDr. Lynne Maquat is the J. Lowell Orbison Endowed Chair and Professor of Biochemistry and Biophysics in the School of Medicine and Dentistry, Director of the Center for RNA Biology, and Chair of Graduate Women in Science at the University of Rochester. Research in Lynne’s lab focuses on human diseases and what causes diseases in our cells. She is working to understand how cells function normally, determine what causes diseases, and develop treatments for diseases. In particular, she has been studying a process in cells that causes about one third of all inherited diseases, like cystic fibrosis and Duchenne muscular dystrophy, as well as one third of all acquired diseases, including cancer. Lynne has a Labrador retriever whom she loves taking on walks through the lovely parks and woods in Rochester, New York. She also enjoys exercising through yoga, lifting weights, and doing cardio. She received her BA in Biology from the University of Connecticut and her PhD in Biochemistry from the University of Wisconsin-M
-
711: Researching RNA Regulation of Reproduction in Plants - Dr. Blake Meyers
05/06/2023 Duration: 42minDr. Blake Meyers is a Member Principal Investigator at the Donald Danforth Plant Science Center and a Professor in the Division of Plant Sciences at the University of Missouri. The focus of Blake’s research is on small RNAs in plants. His lab studies how RNAs are used to regulate the complex machinery of cells, particularly in the context of plant reproductive biology. When he’s not conducting research in the lab, Blake loves to travel both for work and for fun. Blake strives to balance his family life with his science, and he also enjoys reading cookbooks and experimenting in the kitchen at home. He received a B.A. in Biology from the University of Chicago, and went on to receive his MS and PhD in Genetics from the University of California, Davis. Afterwards, Blake completed postdoctoral fellowships at Dupont Genomics and at the University of California, Davis. Before accepting his current positions, Blake was the Edward F. and Elizabeth Goodman Rosenberg Professor and Chair of the Department Plant and Soil