Foodie Pharmacology

Seed oils are everywhere. From salad dressings to snack foods, they’ve become a quiet staple of the modern diet. But how did they get there, and what do we really know about their impact on human health? This week on Foodie Pharmacology, Dr. Cassandra Quave sits down with nutritionist Cherie Calbom, MS, known as “The Juice Lady,” to unpack the rise of industrial seed oils and the debate surrounding them. Cherie shares her personal journey into nutrition, which began with a serious health crisis and led her to rethink the role of food in healing. Together, they explore what seed oils actually are, how they are processed, and why their chemical structure makes them vulnerable to oxidation. The conversation traces their history from industrial byproducts to “heart-healthy” staples, shaped by wartime supply chains, shifting dietary guidance, and powerful marketing. They also dig into where these oils are hiding in everyday foods, why they can be difficult to avoid even when you are trying to eat well, and how to

Spring is here, and seasonal pollen along with it! This week on Foodie Pharmacology, Dr. Cassandra Quave speaks with Gary Falcetano, PA-C, AE-C, Senior Manager of Global Medical & Scientific Affairs in Allergy at Thermo Fisher Scientific and a longtime clinician and educator in asthma and immunologic disorders, about pollen food allergy syndrome and why certain fresh foods can suddenly cause itching or irritation during allergy season. Also known as oral allergy syndrome, this condition stems from cross-reactivity between pollen proteins and similar proteins found in plant foods. Gary explains how this immune mix-up happens, why symptoms are typically limited to the mouth and throat, and why something as simple as cooking an apple can make it more tolerable. They also cover how common this syndrome is, why it is frequently overlooked, and how clinicians distinguish it from more serious food allergies using detailed history and targeted testing. The conversation highlights the role of IgE, component-resolv

What if the key to reducing food waste, strengthening community, and reconnecting with our food systems is already in your kitchen? In this episode of Foodie Pharmacology, Dr. Cassandra Quave speaks with Dr. Julia Skinner, food writer, fermentation expert, and founder of the Culinary Curiosity School, to explore the practice of food preserving. From fermentation to freezing, Julia shares how preserving is not just a set of techniques but a way of thinking about food with intention and creativity. They discuss her upcoming book, Essential Food Preserving, which takes an ingredient-first approach. Instead of rigid recipes, it asks a simple question: what can you do with what you have right now? That mindset opens the door to everything from fruit leathers and infused vinegars to fermented drinks and pantry staples built from scraps. They also explore the deeper reasons preserving matters. These practices are rooted in food security, seasonality, and survival. Today, they offer a powerful way to reduce waste and

Flowers may seem delicate, but they have transformed the planet! In this episode of Foodie Pharmacology, Dr. Cassandra Quave speaks with Dr. David George Haskell, author of the new book How Flowers Made Our World, about the revolutionary rise of flowering plants. They discuss how grasses helped shape human evolution as “grass apes,” why orchids rely on intimate fungal partnerships, and how floral chemistry communicates with pollinators through scent and even electrical fields! From the endosperm that feeds much of humanity to the cultural and aesthetic power of flowers, this conversation examines how flowering plants engineered ecosystems, nourished civilizations, and continue to shape our future. How Flowers Made our World: The Story of Nature’s Revolutionaries is available for pre-order now! Learn more at https://dghaskell.com/  

What if the future of antimicrobial discovery lies buried in medieval manuscripts? In this episode of Foodie Pharmacology, Dr. Cassandra Quave speaks with microbiologist Dr. Freya Harrison of the University of Warwick about the emerging field of “Ancient-biotics”. They examine how early medieval remedies such as Bald’s eyesalve are being reconstructed and tested against modern antibiotic-resistant biofilms. Dr. Harrison explains how her lab builds infection models that mimic the human body, why biofilms are so difficult to treat, and how combinations of natural products like honey and vinegar may hold clues to new antimicrobial strategies. This conversation bridges microbiology, Medieval texts, and pharmacology showcasing how historical knowledge can still inform modern medicine.  

Inflammation is essential for healing, but when it becomes chronic, it can quietly drive joint pain, blood sugar imbalance, autoimmune conditions, and long-term disease. In this episode of Foodie Pharmacology, Dr. Cassandra Quave speaks with Dr. Josh Redd, founder of RedRiver Health and Wellness and author of The 30-Day Inflammatory Reset, about the root causes of chronic inflammation. They discuss how ultra-processed diets, environmental exposures, stress, hormonal imbalance, and even trauma contribute to inflammatory load, and what practical steps individuals can take to support immune balance through nutrition and lifestyle change. Learn more about Josh’s work at DrJoshRedd.com  

Sake sits at the intersection of fermentation science, ritual, and food culture. In this episode of Foodie Pharmacology, Dr. Cassandra Quave is joined by Dr. Eric C. Rath, professor of history at the University of Kansas and author of Kanpai: The History of Sake. Together, they explore what sake really is, how fermentation with koji mold transforms rice into alcohol, and why sake has played such a central role in Japanese ritual, everyday life, and food culture. The conversation also traces the history of home brewing, the rise of izakaya gastropubs, and the emergence of American sake as both adaptation and innovation.

In the remote Alaskan wilderness, survival is not a simple metaphor. It is an act of daily practice. In this episode of Foodie Pharmacology, Dr. Cassandra Quave reconnects with Sue Aikens, best known from National Geographic’s Life Below Zero, to talk about her memoir North of Ordinary. Broadcasting from Alaska, Sue reflects on a life shaped by abandonment, fierce independence, and learning to endure both emotional and physical extremes—from brutal winters and isolation to surviving a grizzly bear attack. This conversation explores resilience, the role of helpers (human and animal), and what it means to build a sense of self when the wilderness strips everything else away.

For decades, Alzheimer’s research has been shaped by a dominant hypothesis, enormous funding streams, and the promise of breakthrough cures. But what happens when the science itself is compromised? In this episode of Foodie Pharmacology, Dr. Cassandra Quave sits down with investigative science journalist Charles Piller to unpack the revelations behind his book Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s. We examine how image manipulation, groupthink, and institutional failures distorted the Alzheimer’s research landscape for years, shaping clinical trials, drug approvals, and patient expectations. This conversation goes beyond a single disease to examine research integrity, reproducibility, and the human cost of getting science wrong.

This week on Foodie Pharmacology, we explore the cultural, scientific, and social dimensions of kava (Piper methysticum) with Douglas La Rose, Executive Director of the Kava Coalition. We discuss kava’s roots in Pacific Island traditions, how it’s prepared, what the new AHP monograph means for safety and standards, and why this non-alcoholic beverage is gaining global interest as a pro-social, calming alternative. Douglas shares insights from his work supporting education, responsible use, and sustainable industry growth, offering a grounded look at how this plant bridges community, culture, and modern wellness. #FoodiePharmacology #Kava #Ethnobotany #PlantMedicine #WellnessCulture #NaturalProducts #KavaCoalition

What makes ibogaine such a remarkable plant-derived compound? I sit down with Jonathan Dickinson, CEO and co-founder of Ambio Life Sciences, to explore the fascinating neuropharmacology of this alkaloid and its profound impact on the brain. Jonathan is an expert on ibogaine, with more than 15 years of experience spanning clinical care, traditional practice, and psychedelic research. We discuss iboga’s deep cultural roots in Central and West Africa, its role in Bwiti spiritual traditions, and how modern science is uncovering its potential in treating addiction, trauma, and neurological disease. Jonathan also shares insights from his pioneering work in ethical sourcing, including the first Nagoya-compliant export of iboga from Gabon, and highlights promising studies on neuroregeneration, multiple sclerosis, and traumatic brain injury. To learn more about his work, visit https://ambio.life/    #iboga #pscyhedelic #addiction #ibogaine #naturalproduct #addiction #podcast

What if the future of egg farming could eliminate one of the industry’s most difficult animal welfare issues—male chick culling? Thanks to in-ovo sexing technology, that future is here. This week on Foodie Pharmacology, I talk with Jasen Urena, Vice President of NestFresh, about the launch of their Humanely Hatched™ eggs—the first in the U.S. to ensure only female chicks are incubated. It’s a groundbreaking step that transforms both animal welfare and consumer choice. Jasen shares his journey at NestFresh and how the company has been at the forefront of ethical innovation, from pioneering Non-GMO Project Verified and Regenerative Organic Certified™ eggs to introducing reusable distribution systems that cut emissions and boost traceability. We discuss the promise of regenerative agriculture, how consumer demand is reshaping food systems, and why bold moves are often the catalyst for lasting change in legacy industries. Whether you care about sustainability, farm animal welfare, or just want to understand where

Plants are master chemists. From caffeine and nicotine to powerful drugs like colchicine, they manufacture an incredible array of molecules that defend against pests, attract pollinators, and sometimes even become lifesaving medicines for humans. But how exactly do plants build these complex compounds, and why do they make them in the first place? This week, I sit down with Dr. Ryan Nett, Assistant Professor of Molecular and Cellular Biology at Harvard University, to explore the fascinating world of plant biosynthesis. We talk about how plants orchestrate molecular “assembly lines” using specialized enzymes, why some of the most promising medicines are so difficult to source from nature, and how advances in genetics and synthetic biology are opening new doors to sustainable drug production. Dr. Nett shares insights from his research on alkaloids such as huperzine A, investigated for Alzheimer’s disease, and colchicine, a historic treatment for gout and inflammation. We also discuss the grand challenges of pla

Food allergies affect millions of children and adults worldwide—and the numbers are rising. This week on the show, Dr. Quave speaks with Dr. Sarita Patil, Assistant Professor of Medicine at Harvard Medical School and Co-Director of the MGH Food Allergy Center, to explore the science behind allergic reactions. They discuss the differences between food allergies and intolerances, the rise in childhood allergies, and how early exposure to allergenic foods can help prevent these conditions. Dr. Patil shares insights from her latest research on peanut immunotherapy and the role of protective antibodies in reducing severe reactions. She also explains eosinophilic esophagitis, a chronic condition linked to food allergens that affects the esophagus. The conversation covers key topics such as the hygiene hypothesis, the influence of breastfeeding and the microbiome on food allergies, and the challenges of managing food allergies in the context of food insecurity. Whether you are caring for someone with food allergies

What if our future food security depended not on fields of grain, but on forests of trees? In this episode of Foodie Pharmacology, I sit down with Elspeth Hay, author of Feed Us with Trees: Nuts and the Future of Food and host of the Local Food Report on CAI NPR. Elspeth takes us on a journey through oak groves and chestnut stands to explore how nut-bearing trees once fed the world—and could again. We unpack the ecological power of keystone species like oaks and the role of fire in maintaining these ancient foodscapes. Elspeth shares how acorns, hazelnuts, and chestnuts offer a compelling alternative to industrial crops—and how Indigenous foodways and land management practices hold the key to unlocking their full potential. From forgotten ancestral practices to the modern movement to rewild our diets and ecosystems, this episode is a hopeful call to reconnect with the trees that once sustained us. Learn more about Elspeth’s work at elspethhay.com and follow her on Instagram @elspethhay.   #TreeNuts #WildFoods

This week on the show, Dr. Quave speaks with Dr. Giulia Menichetti, a computational physicist at Harvard Medical School, about one of the most elusive frontiers in nutrition science: the “dark matter” of food. While most nutrition data is focused on a handful of known nutrients, Dr. Menichetti’s “Foodome” Project is charting the vast landscape of overlooked bioactive compounds hidden in everyday ingredients—and using artificial intelligence to unlock their therapeutic potential. From network science and protein targets to AI-powered metabolomics and precision diets, this conversation uncovers how foods interact with our biology in ways we’re only beginning to understand. You’ll learn how ultra-processed foods disrupt this balance, why many food databases are incomplete, and how the future of personalized nutrition might be written not just in our genes—but in the chemical language of our meals.

This week on the show, Dr. Quave speaks with conservation biologist Dr. Daniel Villar about the deep connections between culture, ecology, and traditional knowledge in the Central Andes. Their conversation centers on Lake Titicaca, one of the world’s highest navigable lakes, where Dr. Villar has studied how traditional ecological knowledge (TEK) shapes and responds to environmental change.  They discuss the many uses of the totora sedge—a plant once used to build floating islands, craft artisanal goods, and provide food for people and livestock—and how its management reflects centuries of indigenous governance and adaptation. Dr. Villar also shares his insights on the role of ethnobiology in conservation, the value of cultural diversity in protecting biodiversity, and how his research sheds light on climate resilience. Don’t miss this fascinating look at the science of survival through the lens of cultural and ecological evolution. #Ethnobiology #LakeTiticaca #TEK #BioculturalDiversity  #FoodiePharmacology #C

What if your doctor prescribed kale instead of pills? This week on Foodie Pharmacology, Dr. Quave sits down with Dr. Steven Chen and Nat Irwin to discuss Recipe4Health, a pioneering “Food as Medicine” program transforming how we treat chronic disease. Based in Alameda County, CA, this initiative pairs regenerative and organic produce with health coaching—all covered by Medi-Cal (Medicaid). Learn how fresh, regenerative produce is being prescribed to thousands of patients as part of a broader effort to improve outcomes for chronic conditions like diabetes and depression. This innovative model also delivers ripple effects beyond the clinic—supporting BIPOC farmers, restoring soil health, and advancing equity through the H3E (Health Cubed Equity) framework, which links human, ecological, and economic well-being. Together, we unpack how food, coaching, and community can improve health outcomes, reduce healthcare costs, and nourish both people and the planet. This podcast episode is sponsored by The Periodic Table

Psilocybin and the Fountain of Youth with Dr. Louise Hecker Could magic mushrooms hold the key to longer life? In this episode, Dr. Quave chats with Dr. Louise Hecker, Associate Professor at Baylor College of Medicine and Founder of Fibronox, about her groundbreaking research on psilocybin and aging. You may have seen the headlines—her team found that psilocybin slowed cellular aging, reduced oxidative stress, and even extended lifespan in mice. Dr. Hecker shares the origin story behind the study, which started with rooftop workouts and curiosity, and walks us through the science behind her findings. From challenges in getting regulatory approval to designing realistic dosing regimens for her laboratory studies, we discuss what it takes to study psychedelics in the lab. We also explore future directions in longevity research and how this ancient fungal compound might one day support healthier aging. Tune in to learn how psilocybin could reshape the way we think about aging and health. #psilocybin #psychedelic

Menus aren’t just lists of food—they’re time machines. This week on Foodie Pharmacology, Dr. Cassandra Quave returns to Season 7 with literary food historian Dr. Nathalie Cooke of McGill University. Together, they explore how menus offer rich clues into the cultural, economic, and even medical mindsets of past centuries. From elephant soup on menus to how Coca-Cola and cigarettes once appeared as health tonics, you’ll hear surprising stories of how dining habits—and health claims—have evolved. Discover how art, identity, and even politics show up on the plate, and how modern “no-choice” tasting menus harken back to royal traditions. Don’t miss this fascinating dive into culinary history through the lens of Nathalie’s latest book, Taste and Traditions: A Journey Through Menu History.