Neuroscientists Talk Shop

On March 27, 2025, we spoke with Nace Golding about the auditory pathways in the brainstem and midbrain. We focused on the inferior colliculus, and on identifying the key cell types that make up that essential but mysterious midbrain auditory nucleus. Guest:Nace Golding, Professor, Department of Neuroscience and the Center for Learning and Memory, University of Texas at Austin.Participating:Marina Silveria, Department of Neuroscience, Developmental and Regenerative Biology, UTSAHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSAThanks to Jim Tepper for original music

On March 20, 2025 we spoke with the speakers at our annual UTSA Neuroscience Symposium for 2025, entitled "Prefrontal Cortical Functions Beyond Fear". The panel talked about the contribution of medial prefrontal cortex in fear, threat and safety learning, cognitive flexibility, psychiatric disorders, recent and remote memory, and some other things. GuestsAnthony Burgos-Robles, Department of Neuroscience, Developmental and Regenerative Biology, UTSALaura Denardo, Department of Physiology, UCLA School of MedicineJason Keller, HHMI Janelia Research CampusDavid Morilak, Department of Pharmacology, UT Health San AntonioHostCharles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA

On February 27, 2025 we were joined by Xue Han about using genetically expressed fluorescent voltage sensors to measure transmembrane voltage simultaneously in multiple neurons in the brain of awake behaving animals over days or weeks. She explained how the genetic sequences for the voltage sensor molecules are found and perfected, how they are delivered to the neurons of interest, the challenges of measuring voltage by changes in fluorescence, and the kinds of questions whose solutions are waiting for this technology. Guest:Xue Han, Professor, Department of Biomedical Engineering, Boston UniversityHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSAThanks to Jim Tepper for original music

On February 13, 2025 we met with Yin Shen to discuss the contribution of cis-regulatory non-coding DNA sequences in controlling gene expression, and how variation of these regions in microglia may be risk factors in idiopathic brain diseases.Guest:Yin Shen, Professor in the Department of Neurology and the Institute for Human Genetics in the Weill Institute for Neurosciences at the University of California San Francisco School of MedicineParticipating:Melanie Carless, Department of Neuroscience, Developmental and Regenerative Biology, UTSAHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSAThanks to Jim Tepper for original music

On January 30, 2025 we spoke with Ekaterina (Katya) Likhtic about the amygdala, prefrontal cortex, and the circuits responsible for fear conditioning and extinction. She informed us about the special contribution of the amygdala to emotion and emotional learning, and we discussed the special place of fear conditioning as a model for learning generally. Guest: Katya Likhtic, Associate Professor, Department of Biology, Hunter City University of New York. Participating: Tony Burgos-Robles, Department of Neuroscience, Developmental and Regenerative Biology, UTSA. Itamar Lerner, Department of Psychology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA.

On December 13, 2024 we spoke with the speakers at our annual UTSA Neuroscience Symposium, on the Basal Ganglia Circuitry. Topics of discussion included the heterogeneity of cells and connections, the usefulness of the idea of cell types (or lack thereof), and the relationship between neuromodulators and fast synaptic transmission. Sorry about the sound quality on this one. Guests: Charles Gerfen, Senior Investigator, National Institute of Mental Health Joshua Goldberg, Associate Professor, Department of Medical Neurobiology, The Hebrew University Zayd Khaliq, Senior Investigator, National Institute of Neurological Diseases and Stroke Tianyi Mao, Senior Scientist, Vollum Institute, Oregon Health & Science University Gilad Silberberg, Professor | Docent, Department of Neuroscience, Karolinska Institute D. James Surmeier, Professor, Department of Physiology, Feinberg School of Medicine, Northwestern University Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA

On December 5, 2024 we spoke with Jason Chen about G-protein signaling in the mammalian photoreceptors, and the G-protein regulator proteins that govern the speed of transduction and the temporal resolution of vision. Guest: Jason Chen, Professor in the Departments of Molecular Medicine and Ophthalmology, and Joe R. and Teresa Lozano Long Chair in Retinal Signaling at UT Health San Antonio. Participating: Erika Tatiana Camacho, Departments of Mathematics and Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to James Tepper for original music

On November 21, 2024 we spoke with Jonathan Fadok on the brain circuits that choose whether an animal will freeze or try to escape in the presence of a dangerous stimulus. Guest: Jonathan Fadok, Associate Professor in the Department of Psychology and the Brain Institute at Tulane University. Participating: Tony Burgos-Robles, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Matt Wanat, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to James Tepper for original music

On November 14, 2024 we spoke with Claudio Punzo on the metabolic interdependence of the retinal pigment epithelium and the photoreceptors of the retina, and its implications for the degenerative process in macular degeneration Guest: Claudio Punzo, Associate Professor in the Department of Ophthalmology and Visual Science at the University of Massachusetts Medical School Participating: Erika Tatiana Camacho, Departments of Mathematics and Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA

On November 7, 2024 we spoke with Carlos Bassetto about the relationship between molecular structure and functional states of the ion channels that underlie all electrical signals in the nervous system. Guest: Carlos Bassetto, Assistant Professor, Department of Physics and Astronomy, UTSA Participating: Fidel Santamaria, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to James Tepper for original music

Neuroscientists Talk Shop: Raju Metherate on nicotine and auditory processing On October 31, 2024 we spoke with Raju Metherate, on the sites of action of nicotine in the auditory pathway and the mechanism by which it enhances cortical responses to sound. Guest: Raju Metherate, Professor, Department of Neurobiology and Behavior, University of California, Irvine Participating: Alfonso Apicella, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to James Tepper for original music

On October 17, 2024 we talked with Eric Fortune about the electric field sensory system in weakly electric fish and its function in social communication, predation and spatial localization. Eric explained how his collaboration with engineers and application of control systems opened a window on the function of the animal's movement in this sensory system. Guest: Eric Fortune, Associate Professor of Biological Sciences, New Jersey Institute of Technology Participating: Francesco Savelli, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Todd Troyer, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to Jim Tepper for original music

On October 10, 2024 we met with Ranmal Samarsinghe to talk about the use of cortical assembloids, three-dimensional cultures containing both excitatory and inhibitory neurons. to explore the development and function of the cerebral cortex. Guest: Ranmal Samarasinghe, an Assistant Professor in the Department of Neurology at the David Geffen School of Medicine at UCLA. Participating: Sara Mirsadegi, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA

On September 26, 2024 we spoke with Jones Parker about dopamine receptors, the changes in neuronal activity produced by various antipsychotic drugs, and their relationship to antipsychotic efficacy in humans. Guest: Jones Parker, Assistant Professor in the Departments of Neuroscience, Pharmacology, Psychiatry and Behavioral Sciences at Northwestern University Feinberg School of Medicine Participating: Matt Wanat, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to James Tepper for original music

On September 23, 2024 we met with Andy Groves to discuss the inner ear and hearing loss, why we can't regenerate our auditory receptors, and how we might someday be able to rebuild our auditory epithelium using gene therapy. Guest: Andy Groves, Professor and Vivian L Smith Endowed Chair in Neuroscience, Departments of Neuroscience and Molecular and Human Genetics, Baylor College of Medicine. Participating: Marina Silveira, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to Jim Tepper for original music

On September 12, 2024 we got to talk with Brian Lundstrom about the origin of epilepsy, the use of electrical recordings in its diagnosis, and brain stimulation as a treatment. Brian explained the difficulties of inferring cortical network function from EEG signals, and the problem of studying a disease whose symptoms manifest rarely and intermittently. Guest: Brian Lundstrom, Associate Professor in Neurology and Biophysics in the division of Epilepsy, Department of Neurology, in Mayo Clinic Participating: Fidel Santamaria, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to Jim Tepper for original music

On September 9, 2024 we got to talk to Marina Silveira about the inferior colliculus, its place in the auditory pathway, and the effort to understand its cellular makeup, internal structure, and auditory functions. Guest: Marina Silveira, Assistant Professor, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to Jim Tepper for original music

On August 29, 2024 we spoke with Melanie Carless about cellular models of Alzheimer's disease generated using direct programming of brain cells from fibroblasts derived from patients, which can be used to find epigenetic signatures of the disease. Guest: Melanie Carless, Associate Professor, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Participating: Uchit Bhaskar, Department of Neuroscience, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Department of Neuroscience, Developmental and Regenerative Biology, UTSA

On May 2, 2024 we spoke with Skirmantas Janusonis on the peculiar morphology and spatial distribution of the serotonin innervation of the brain, and his idea that it can be described using the mathematics of fractional Brownian motion. We consider the kind of developmental mechanisms that could be responsible. Guest: Skirmantas Janusonis, Associate Professor, Department of Psychological and Brain Sciences, University of California, Santa Barbara. Participating: Fidel Santamaria, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to Jim Tepper for original music

On April 25, 2024, we met with the 5 speakers for this year's Annual Neuroscience Symposium at UTSA to discuss epigenetics and nervous system development. We discussed the best known molecular mechanisms that control patterns of gene expression and current limitations faced in studies of those mechanisms. We also discussed the promise of epigenetics to explain the differentiation of nervous system cell types, mechanisms of developmental, neuropsychiatric and neurodegenerative disorders. Guests: Melanie Carless, Associate Professor, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Christine Ladd-Acosta, Associate Professor, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health Paulino Ramirez, Postdoctoral Fellow, Department of Cell Systems and Anatomy, UT Health San Antonio Alexey Soshnev, Assistant Professor, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Hehuang "David" Xie, Associate Professor, Department of Biomedical