Discovery

Could creating "blood" in the laboratory make infections passed on through blood transfusions a thing of the past? Vivienne Parry investigates.The drive behind the quest for creating a blood substitute was originally from the US Military - during the Vietnam War a clean, reliable and portable alternative to donor blood would have helped to save many lives. Donated blood can only be kept for a limited time, needs refrigerating and has to be cross matched according to which ABO group people belong to. The "universal donor" - O negative blood - can be used on accident victims before a match is found. But it's in very short supply and often many units of blood are required.The history of creating blood has had a chequered past - with some products abandoned because of side effects and others proving too costly to produce. One analysis of clinical trials on blood substitutes in 2008 revealed a higher incidence of heart attacks in patients who'd been given them, compared with those who received human blood.Some sci

Gene therapy - repairing malfunctioning cells by mending their DNA - offers an elegant solution to diseases, such as cystic fibrosis, caused by a single flawed gene. It's a very simple concept to describe - simply insert a 'normal' gene to do the job - but it's this process, the delivery of the gene, that's proving to be so difficult and time consuming. Since the first human study began in 1990 the field has struggled with various technical challenges and set-backs.But over a decade on, researchers are beginning to report successes in treating several devastating diseases. Geoff Watts finds out about some of the new techniques for gene therapy, and discovers how these are now being used in a trial of a new method of gene therapy for cystic fibrosis. Twelve years ago, a group of scientists from Imperial College in London, Oxford and Edinburgh formed the Cystic Fibrosis Gene Therapy Consortium. This year they started the world's biggest trial of gene therapy for cystic fibrosis.Funded by the Cystic Fibrosis Tru

Alan Turing, born 23 June 1912, is famous for his key role in breaking German codes in World War II. But for mathematicians, his greatest work was on the invention of the computer. Alan Turing's brilliance at maths was spectacular. Aged 22, just a year after his graduation, he was elected a fellow of King's College Cambridge. And it was just a year after that, that he turned his attention to problems in the foundations of mathematics and ended up showing that a simple machine, set up to read and write numbers and to run a few basic functions, could in principle do all the things that are do-able in mathematics. His 'universal' machine was just a concept - a paper tape that could be read, interpreted and acted on robotically. But the concept was profound. World War II shortly afterwards took Turing's talents into other directions, but even while designing machines at Bletchley Park to break the German Enigma codes, he was wondering how much more a computing machine might do - play chess for example.And althoug

Alan Turing - born a hundred years ago on June 23 - is most famous for his key role in breaking German codes in World War II. But for mathematicians, his greatest work was on the invention of the computer. Discovery explores the legacy of the great man with a two-part special.Alan Turing's brilliance at maths was spectacular. Aged 22, just a year after his graduation, he was elected a fellow of King's College Cambridge. And it was just a year after that, that he turned his attention to problems in the foundations of mathematics and ended up showing that a simple machine, set up to read and write numbers and to run a few basic functions, could in principle do all the things that are doable in mathematics. His 'universal' machine was just a concept - a paper tape that could be read, interpreted and acted on robotically. But the concept was profound. World War II shortly afterwards took Turing's talents into other directions, but even while designing machines at Bletchley Park to break the German Enigma codes, h

Two teams of virologists found themselves at the heart of bioterrorism maelstrom late last year when their studies on mutant bird flu were suppressed by US authorities. While security experts feared the reports were recipes for bioweapons of mass destruction, the researchers argued they held important lessons for the threat of natural flu pandemics developing in the wild.Now the authorities have backed down and the reports have been released. Kevin Fong hears how tiny variations in the genes of bird flu can completely change the behaviour of the pathogens and he asks whether deliberate genetic manipulation in the lab can replicate the natural genetic variations occurring in farms around the world.In 2009, the new strain of H1N1 flu emerged from a few villages in Mexico to infect the world in weeks. What experts fear is that a simple genetic change to H5N1 bird flu could allow it to spread as fast, but with far deadlier consequences. They argue that by identifying dangerous variants in the lab first, we'd be b

Astronomer Marek Kukula from the Royal Observatory at Greenwich explores the scientific implications of the forthcoming transit of Venus across the face of the Sun, a rare astronomical event that will not occur again until 2117. Previous transits have helped establish fundamental facts about our solar system, including the distance and relative positions of all the planets that orbit our sun. But now, the forthcoming transit in June 2012, the last this century, will help planet hunters searching for other worlds across the galaxy (exo-planets). As Marek discovers, technology now makes it possible to pinpoint not only a planet's mass, size, and distance from its star but we can also establish whether it has an atmosphere and what that atmosphere might consist of and therefore whether it could theoretically support life. Thanks to the next transit event, the search for another Earth has taken a bold step forward.(Image: Venus (black dot) is silhouetted as it orbits between the Sun and the Earth during the trans

Professor Jim al-Khalili talks to Cern physicist Tejinder Virdee, about the search for the elusive Higgs boson, also known as the "God particle". Last December, scientists working at the Large Hadron Collider caught a tantalising glimpse of the Higgs; but they need more data to be sure of its existence. Twenty years ago, Tejinder set about building a detector within the Large Hadron Collider that's capable of taking 40 million phenomenally detailed images every second. Finding the Higgs will validate everything physicists think they know about the very nature of the universe: not finding it, will force them back to the drawing board. By the end of the year, we should know one way or the other.

Plastic Surgery does not always have a good press, more often associated with the excesses of Hollywood. But the birth of modern day reconstruction has far nobler roots. Dr Kevin Fong looks at the surprising, and heroic origins of the field of plastic and reconstructive surgery. It is a field that was born in response to the great air-battles of World War II, and the development of a new fighter plane - the Hawker Hurricane - that left its legacy not just in terms of success in the air, but in the devastating injuries caused to many of the airmen who flew them. He looks at the work of pioneering surgeon Archie McIndoe and his brave airmen "guineapigs" who underwent months, if not years, of painful surgery that led to the birth of modern day reconstructive surgery.

How fixed are our moral beliefs? Can these beliefs be reduced to neurochemistry?While we may believe that our moral principles are rigid and based on rational motives, psychological and neuroscientific research is starting to demonstrate that this might not actually be the case.In this edition of Discovery, Dr Carinne Piekema investigates how scientific studies are starting to shed light on how our social behaviour is affected by our environment and neurochemistry. She discusses with Carol Dweck about how people's moral opinions can be modified through behavioural techniques, and with Molly Crockett and Paul Zak about how similar effects can be brought about by directly altering brain chemistry.While this knowledge might have future benefits, the ability to alter people's behaviour and attitudes towards others also raises potential ethical issues. In the final part, Carinne talks with neuroethicist Neil Levy who invites us to consider the philosophical questions raised by such advances.

Imagine if your health as an adult is partly determined by the nutrition and environment you were exposed to during a critical period of development - the first 1000 days of life. A strong body of scientific evidence supports this explosive idea, and is gradually turning medical thinking on its head. To understand the cause of chronic adult disease, including ageing, heart disease, diabetes, osteoporosis, obesity and lung problems we need to look much further back than adult lifestyle – but to the first 1000 days.Dr Mark Porter investigates this influential idea and meets the world experts leading this burgeoning field of research. He talks to David Barker, Professor of Clinical Epidemiology at the University of Southampton and the man behind the Barker Theory. This links the risk of developing illnesses in adult life to poor nutrition in the womb – typically evident when a baby is born underweight. Low birth weight is associated with a number of long term health problems in adults, ranging from osteoporosis

One hundred years ago, the first humans reached the South Pole of this planet. More than 40 years ago, man first walked on the moon. When will our species first set foot to explore the planet Mars? Kevin Fong seeks a likely launch date, and asks who will get us there and why we really need to explore the Red Planet.

Can the heroic age of Antarctic exploration help to show us the way back to the Moon?One hundred years ago, Scott reached the South Pole. However, more than four decades passed before people went back there. On the Moon, Neil Armstrong took his leap for mankind in 1969 and it has been forty years since the last astronaut left the lunar surface. Presenter Kevin Fong talks to space scientists and historians to find out if Robert Scott's Antarctic exploits provide a road map for future human exploration of the Moon and the planet Mars.Imperial and geopolitical motivations lay behind both South Polar exploration and the effort which took humans briefly to the lunar surface. But what would get us back to the Moon - would it be geopolitical rivalry or science?In times of economic austerity (in the West at least), what scientific questions are important enough to justify exploration of the Moon? The six short Apollo visits to the lunar surface were enough to crack the mystery of how the Moon itself formed - namely t

Kevin Fong looks beyond the failure of Robert Falcon Scott's expedition to be the first to reach the South Pole and focuses instead on the scientific legacy of Scott's explorations of Antarctica between 1901 and 1912.In recent years, much has been written about Scott the polar loser and bungler. But that personalised focus ignores the pioneering scientific research and discoveries. The revelations transformed Antarctica from an unknown quantity on the map into a profoundly important continent in the Earth's past and present. Before Scott and Shackleton trekked across the vast ice sheets in the early 1900s, no-one was sure whether there was even a continent there. Some geographers had suggested Antarctica was merely a vast raft of ice anchored to a scattering of islands. The science teams on Scott's expeditions made fundamental discoveries about Antarctic weather and began to realise the frozen continent's fundamental role in global climate and ocean circulation. They discovered rocks and fossils which showed

To mark the 100th anniversary of the sinking of the Titanic, the BBC's Sean Coughlan narrates one of the most authentic versions of events in existence. Using voice synthesis to re-create the strange, twitter-like, mechanical brevity of the original Morse code, this programme brings to life the tragedy through the ears of the wireless operators in the area that night.On the night of the disaster, the network of young Marconi wireless operators on different ships and land stations frantically communicated with each other across the cold expanses of the North Atlantic in an effort to mount a rescue for the doomed vessel. All these messages were recorded at the time in copper-plate handwriting, now scattered across the world in different collections, but together forming a unique archive. Conceived and created by Susanne Weber.Producer: Alex Mansfield

In the last of the Global Body series, Lynne Malcolm is joined by a panel of experts to discuss the future of the health of the human body.Lynne is joined by, Tony McMichael – Professor of Population Health at the Australian National University in Canberra; Professor Maxine Whittaker, form the Australian centre for International and Tropical Health at the University of Queensland and Professor Robyn Norton, Director of the George Institute and Professor of public health at the University of Sydney and Professor of Global Health and James Martin Professorial Fellow, University of Oxford.(Image: Computer artwork of the blood circulation system in a human figure. Credit: Science Photo Library)

As part of the BBC World Service's Human Race season, ABC in Australia's Lynne Malcolm explores how Homo sapiens have adapted to changes in their environment, economy and social structures; how health is affected by new environments and lifestyles; and what might happen to the human race in the future? Is the 'Hollywood Dream' of a city of beautiful, fit, wealthy people anything near the truth for this huge city? It's a city with a long history of immigrants settling from all over the world. Lynne Malcolm explores how some of these inhabitants have adapted biologically to their new environment over time, and what the impact is on their health and bodies. BBC Correspondent, Valeria Perasso, discovers however, that it's not all good news, with obesity on the rise in the city and there are also massive discrepancies in the standards of health, and quality of life amongst its inhabitants.(Image: a female face surrounded by a distorted DNA autoradiogram. Credit: Science Photo Library)

As part of the BBC World Service's Human Race season, ABC in Australia's Lynne Malcolm explores how Homo sapiens have adapted to changes in their environment, economy and social structures; how health is affected by new environments and lifestyles; and what might happen to the human race in the future? Lured by the bright lights, or driven from the countryside by political and economic turmoil, population pressures, and environmental vulnerability, billions of people have been migrating to the cities in the developing world. The BBC's correspondent in Manila Kate McGeown, discovers what happens to our human bodies when we leave the fields and shorelines and head into the big city. She reports back to Lynne, how traffic, pollution, smoking, overcrowding and lack of affordable fresh food is sparking an epidemic of diabetes, heart disease, hypertension and cancers. Often outweighing the benefits of higher wages, better access to healthcare and education.

As part of the Human Race season on the BBC, Discovery starts its exploration into the Global Body. Over the next 4 weeks, Lynne Malcolm finds out how the modern world is affecting our biology. The series starts in Sri Lanka, where it asks whether the predominantly rural lifestyle of fishermen and farmers is well suited to the human body. BBC Correspondent Charles Haviland takes us to the shores of Sri Lanka to see what life is like for fishermen and to the mountains where people live off the variety of crops they grow for themselves. These populations are pretty healthy. But he also discovers that some of the rural inhabitants – the tea pickers – have a much harder time. There’s a report on how an inherited disease, thalassaemia, that makes people debilitated, and is quite common amongst Asian people is treated in Sri Lanka. And the programme discovers that thalassaemia survives because it confers resistance to malaria.(Image: Conceptual computer artwork of a male figure seen against autoradiograms of geneti

It's nearly a year (11 March 2011) since Japan was struck by a huge earthquake and Tsunami. Clouds of radioactive fall out from damaged nuclear reactors at the Fukushima Daiichi power station spread across heavily populated areas - many kilometres from the plant. The government and power company TEPCO have been heavily criticised for not telling the local population soon enough about what was going on - in many cases people evacuated to areas with higher radiation levels than those they fled. As a result, deep mistrust developed towards government or TEPCO pronouncements on the nuclear incident. In this special one hour edition of Discovery Mariko Oi, visits the Fukushima prefecture to find out what has happened since. She meets scientists working to piece together an accurate picture of the effects of the radioactive fall out, both on the environment and human health. She hears from local community grassroots organisations, many people living in fear of radiation, they argue for a mass clean up operation

Located in the western pacific, the Mariana Trench is the deepest part of the ocean, plunging down 11km. Down there it's pitch black, icy cold and the pressure is immense. Now explorers with funding from the private sector are planning to return to the bottom of the Trench, for the first time for over 50 years. Rebecca Morelle meets Jim Gardner, who works for the US Center for Coastal and Ocean Mapping, and has just completed the most detailed survey ever of the Mariana Trench, using sonar.Alan Jamieson, an ecologist at Oceanlab at the University of Aberdeen in Scotland, uses remote controlled submersibles to study the animals and plants that live at extreme pressure in the deepest parts of the oceans. He tells Rebecca why he believes it is preferable to deploy robots rather than humans to do this research. Legendary marine biologist and underwater explorer, Sylvia Earle, argues that it is essential for us to visit the depths of the ocean and see the extraordinary environment with our own eyes. As the forme