Discovery

Sex is one of Nature’s great forces of change. Yet it is one of life’s great mysteries. Adam Rutherford investigates how and why living things first invented sex about 1.5 billion years ago. He begins by exploring why so many animals and plants have carried on doing it, given that sex has some big disadvantages compared to asexual reproduction.

The oldest known sexual beings, a 400 million year old fish sex movie and the prehistoric turtles which were fossilised in the act of copulation. Discovery this week is strictly adults-only as we begin a three-part natural history of sex. Adam Rutherford talks to the scientists studying the world’s most revealing fossils. (Image: Two carettocheylid turtles, fossilised in mating position. Credit: The Royal Belgian Institute of Natural Sciences)

From smell to navigation, it seems that some of the hardest problems in biology could be solved with the insights from theoretical physics.The physicist Erwin Schrödinger wrote a book in the 1940s called “What is Life?” in which he speculated on the role of quantum mechanics on the life sciences. Almost 70 years later, both quantum mechanics and biology have moved on a long way. But are the two fields converging?Avian navigation, light harvesting in photosynthesis and even olfaction – the science of smell, all provide hints that nature may have been making use of some of quantum mechanics’ weirder tricks for quite some time.Jason Palmer looks at the emerging field of quantum biology.(Music: ©Will Lenton @Mu_Mech)

A decade ago, the Human Genome Project revealed that only 1% of our DNA codes for the proteins that make our bodies. The rest of the genome, it was said, was junk, in other words with no function. But in September another massive international project, called ENCODE, announced that the junk DNA is useful after all. Adam Rutherford reports on the significance of this major discovery. He visits the Wellcome Trust Sanger Institute outside Cambridge where the vast amount of data about our genome is produced and analysed. And he finds out how this new information is beginning to give insights into the origin and treatment of diseases, such as cancer. Adam also discovers that the study of genomes has changed dramatically since he finished his PhD: it's now all done in machines and not at the lab bench.

Sir John Gurdon talks to Jim al-Khalili about how coming bottom of the class in science was no barrier to winning this year's Nobel Prize for Physiology or Medicine. We're familiar with Dolly the Sheep but many people find the idea of cloning humans rather disturbing. It seems to cut to the core of who we are; but, scientifically speaking, we are getting closer to a time when cloning people might be possible. John Gurdon gives it fifty years. After a famously bad school report for science, he won the Nobel Prize for cloning a frog, decades before Dolly the Sheep. Here he talks to Jim about his pioneering work on cloning and where it all might lead.

Science polymath and celebrated author, Jared Diamond has tackled some of the big questions about humanity: what is it that makes us uniquely human not just a third species of chimpanzee; and why do some societies thrive and others struggle to survive, or collapse?Jim Al-Khalili talks to Jared Diamond about how his passion for the birds of Papua New Guinea overtook his medical interest in the gall bladder, and led him to undertake a scientific study of global history. Once a Professor of Physiology, he became increasingly fascinated by the birds of Papua New Guinea.Now Professor of Geography at University of California in LA, he stresses the vital importance of the environment in determining the success or otherwise of a society. He argues first that it was settled agriculture that enabled the white man to develop guns, germs and steel and later that abuse of the environment is often responsible for their collapse. But can the history of humanity really be understood in much the same way as we might seek to

Andrea Sella is a science showman, whose theatrical demonstrations of chemistry are filling theatres up and down the country. He talks to Jim al-Khalili about his life scientific. Andrea is also Professor of Materials and Inorganic Chemistry at University College London and he and Jim discuss whether he would rather be known for his research into rare metals than for his whizz bang displays.

Baby girls born today in the UK can expect to live to 82 years old, whereas boys on average will die 4 years earlier.Evolutionary biologist Dr Yan Wong looks at the latest evidence suggesting that where ageing is concerned, men seem to be at a genetic disadvantage. From research on ancient Korean eunuchs to laboratory fruit flies, new studies seek the answer to why males across the animal kingdom live faster and die younger.So, is the gender gap here to stay?

The most notorious fraud in the history of Science is the focus of this week’s Discovery. Exactly one hundred years ago, British scientists announced their discovery of fossilised skull and jaw bones of what appeared to be the earliest human – a species of humanity closer to our prehistoric ape ancestors than any found before it. In 1912 it was a sensational find. In 1953 it was revealed as a horrible hoax. Jonathan Amos talks to palaeontologists and archaeologists about the case of Piltdown Man and asks, could anything as scientifically scandalous happen today? He visits Chris Stringer, professor of human origins at London’s Natural History Museum. The museum is putting the original fraudulent specimens on display after almost sixty years of being hidden in disgrace. Archaeologists Miles Russell and Matthew Pope discuss the prime suspect in the case and ruminate on his motivations.Could the world of human origins research be fooled by a hoaxer today?Producer: Andrew Luck Baker

Finding the Higgs boson on July 4th 2012 was the last piece in physicists' Standard model of matter. But Tracey Logan discovers there's much more for them to find out at the Large Hadron Collider. To start with there is a lot of work to establish what kind of Higgs boson it is. Tracey visits CERN and an experiment called LHCb which is trying to find out why there's a lot more matter than anti-matter in the universe today. Dr Tara Shears of Liverpool University is her guide. Tracey also talks to physicists who are hoping to find dark matter in the debris of the collisions at the LHC. Scientists know there's plenty of dark matter in the universe, from its effects on galaxies, but they don't know what it is. Tracey discovers that this fact isn't stopping the particle physicists carrying out experiments.(Image: Scientists in front of a screen at CERN during the restart of the Large Hadron Collider in 2009, Credit: AFP/Getty)

Kevin Fong talks to one of the last two men on the Moon, 40 years after the final Apollo 17 mission blasted off on 7 December 1972. As an Apollo astronaut, Harrison Schmitt was special. He was was the only geologist ever to explore the lunar surface. The field work Dr Schmitt did, and the rocks he and his fellow astronauts brought back, revolutionised our understanding of the Moon and the Earth. Dr Schmitt also shares the human experience of running around another planet and explains why he thinks we should go back, and beyond. The conversation also features archive recordings of the two Apollo 17 moon walkers, Schmitt and Commander Eugene Cernan talking from the lunar surface and Challenger module to NASA’s mission control in Houston in 1972.Producer: Andrew Luck-Baker

In this programme, Geoff Watts meets researchers attempting to unlock the mysteries of hallucination as well as some of those who experience the phenomenon. Geoff visits Dr Dominic Ffytche of the Institute of Psychiatry in London, and undergoes a stroboscopic experiment designed to induce hallucinations in subjects whilst their brains are being scanned. We hear some of the vivid accounts from hallucinators, including Doris, who has macular degeneration. Over the last year, her failing eyesight has resulted in an array of objects and images appearing before her with startling clarity, from relatively benign baskets of flowers to the rather more distressing sight of dark, haunting figures sitting by her bed. Her condition is known as Charles Bonnet Syndrome and Dr Ffytche estimates that over two million people suffer from this in the UK alone, mostly in silence, due to the fear of being labelled as 'mad'. Geoff also visits Kelly Diederen's lab at Cambridge University, which is investigating the origin of audito

Geoff Watts meets researchers attempting to unlock the mysteries of hallucination as well as some of those who experience the phenomenon. Hallucinations aren't what they used to be. Time was when reporting a divine vision would bring fame or fortune. The Enlightenment changed all that and nowadays you'd be more at risk of being handed a prescription for a major tranquilliser for reporting what you saw or heard. Hallucinating, in essence, the experience of seeing or hearing (and sometimes smelling or touching) something that by any objective measure, isn't there, has been linked to a wide variety of causes. But there are also examples of otherwise 'healthy' individuals who have experienced vivid and sometimes distressing hallucinations. With the advent of fMRI scanning, researchers can observe the hallucinating brain in action, it is these 'healthy' individuals who are beginning to open the doors of perception and which may provide new insights and treatments for psychosis and schizophrenia. (Image: Coloured l

Gaia Vince concludes her journey through the geological age humans have launched. After climate change and mass extinction, she now explores moves how the world’s cities and manufactured artefacts (from mobile phones to plastic bottles) might become 'fossilised' and incorporated into the geological record. Some are bound to survive in crushed form for the rest of the Earth’s existence. Any distant-future geologist would recognise them as strange features unique in the planet’s 4 billion year rock record: chaotic rock layers preserving urban rubble and underground tunnels - mudstones unnaturally rich in zinc, cadmium and mercury – and the occasional crushed mobile phone or plastic bottle transformed from polymer to delicate coal. These rocks and artificial ‘fossils’ will be evidence of a planetary shift into the new time period, which today’s geologists call the Anthropocene.(Image: A pile of mobile phones, Credit: Getty Images)

Earth scientists say humanity’s impact on the Earth has been so profound that we have started a new geological time period on the planet. They call it, the Anthropocene. Gaia Vince explores our fundamental changes to the biosphere. The accelerating extinctions of animal and plant species: the rearing of agricultural animals in their billions: and, what some describe as, the general ‘macdonaldisation’ of life on Earth. All three factors will leave striking evidence in the fossil record in the limestones and sandstones, forming on the Earth’s surface today. Millions of years in the future, a geologist chipping at the rocks of our times might conclude that something in the world happened as big as the asteroid which wiped out the dinosaurs 65 million years ago.Are we responsible for the sixth great mass extinction in Earth history and forcing the planet down a different trouser leg of geological time, as one scientist puts it?

Humanity’s impact on the atmosphere with fossil fuel burning is so profound that we’re creating a new geological time period, say geologists. They’ve named it, the Anthropocene.In this part of her journey into the Anthropocene, Gaia Vince explores how fossil fuel burning will leave enduring marks in geological record forming on the Earth in current times. Climate change and ocean acidification are in the process of transforming the planet on such a scale that humanity has shifted Earth history into a new geological epoch. Millions of years from now, scientists will be able to read the rocks forming now and see that something profound and unprecedently rapid – from sea level rise to dissolving coral reefs. Drawing from similar episodes in Earth history, leading geoscientists warn of a global blanket of oxygen-starved muds, extinctions of much marine life and a sea level 20 metres higher than today’s.

Humanity’s impact on the Earth is so profound that we’re creating a new geological time period. Geologists have named the age we’re making the Anthropocene. The changes we’re making to the atmosphere, oceans, landscape and living things will leap out of the rocks forming today to Earth scientists of the far future, as clearly as the giant meteorite that ended the Age of the Dinosaurs does to today’s researchers. In this four part series, journalist Gaia Vince looks at the impact of these planetary transformations from the perspective of geological time. When was the last time comparable events happened in Earth history, and are what are the key marks we’re making on the planet that define the Anthropocene?In this first programme, Gaia hears how the hand of humanity on the surface of the continent is geological in its sheer scale and its imprint will remain for millions of years. Through mining and quarrying, we shift billions more tonnes rock and sediment annually than all of the planet’s great rivers a

We are in desperate need of new medicines for the major diseases facing us in the 21st century such as Alzheimer's and obesity. And we are running out of antibiotics that are effective against bacteria that are now resistant to many old varieties. As bringing new and improved drugs to patients becomes more difficult and more expensive - it can take 20 years and around $1 billion to bring a medicine to market. In the second programme looking at the problem with drug discovery, Geoff Watts asks what can be done to get new pharmaceutical treatments to patients.He discovers that the industry is risk averse and regulations to ensure that drugs are safe and effective are burdensome. But there are pilot projects to speed up the process. Geoff finds out that the experts believe that there needs to be a fundamental change in the drug development process, and the key ingredient is collaboration - between industry and academia and between different drug companies. He also discovers that the medical charity, the Wellco

We are in desperate need of new medicines for the major diseases facing us in the 21st Century such as Alzheimer's and obesity. And we are running out of antibiotics that are effective against bacteria that are now resistant to many old varieties. As bringing new and improved drugs to patients becomes more difficult and more expensive - it can take 20 years and around $1 billion to bring a medicine to market - Geoff Watts asks what's gone wrong and what can be done to get new pharmaceutical treatments to patients.Geoff talks to a number of researchers who have worked both within the pharmaceutical industry and publicly funded laboratories to get their views on why the source of drugs has dried up. These include Dr Patrick Vallance, of global pharmaceutical giant GSK, Professor Paul Workman of the Institute of Cancer Research, and Professor Chas Bountra of Oxford University's Structural Genomics Consortium. They argue that the age of the blockbuster drug which can treat millions of patients is over and that we

Nine million people in the UK alone have significant hearing problems. The mechanisms in our ears that help us hear are incredibly sensitive and are easily damanged by environmental hazards such as loud noises and chemicals or simply the passage of time. Despite the fact that many of us will gradually lose our ability to hear as we as a society grow older, many of us don’t actually know that much about the causes and consequences of deafness. What does the world sound like to a deaf person? How do the brain and ears work together to make sense of sound? And how far have scientists come in helping to restore impaired hearing? In this edition of Discovery, Dr Carinne Piekema speaks with Harry Thomas who has been deaf since birth along with experts in the field of auditory neuroscience to find out about what it is like living with hearing loss on a personal and scientific level. By recreating everyday sounds as if heard by someone like Harry wearing a hearing aid or with a cochlear implant, she will also try to