Science In Action

Human Genome Editing: The team meet experts at the Human Genome Editing Summit in London, seeking to cure genetic disease and ensure that it's safe and available to all. Roland Pease hears from Victoria Gray, the first person to be cured of the debilitating and life-shortening disease sickle cell anaemia by gene editing, and from the scientists making it possible. Also, the prospect of work to attempt gene rescue in fetuses before they are born. But the technology is expensive and complex – the question troubling the participants is to ensure people across the world can benefit from it, not just the rich and privileged. And what are the limitations of gene editing? Can it be made more effective, safer? And what of gene edits that will be inherited by future generations?

The long rains of East Africa are forecast to fail again, for the third year running, precipitating a food crisis affecting millions. Science In Action explores the science of the drought, hears about new methods improving forecasts, and what is unusual about the region that makes it so vulnerable.When we think of helium, for many of us balloons and squeaky voices come to mind. But the noble gas is critical for many aspects of modern life – and we’re facing a global shortage. Dr Annie Cheng and her colleagues at the University of Oxford are attempting to solve this by creating a model that has the potential to locate previously untapped reservoirs.Image by Gerald Anderson/Anadolu Agency via Getty ImagesProducer: Roland Pease Assistant Producer: Sophie Ormiston

Cyclone Freddy has made landfall on Madagascar, leaving destruction in its wake. At the time this edition of Science In Action is going to air, Freddy is on course to reach Mozambique and South Africa. Freddy, which has been gaining strength since it originally formed on the 30th of January, is the most powerful southern hemisphere cyclone on record. Professor Francois Engelbrecht provides the science behind the storm system.In the centre of our galaxy, an enormous cloud is heading towards the Milky Way’s supermassive black hole. Dr Anna Ciurlo tells us that this is a unique opportunity to study the influence of the black hole on the cloud’s shape and properties.We’ve heard a lot about balloons floating above Earth recently… but what about sending balloons to Venus? That’s exactly what Dr Siddharth Krishnamoorthy is proposing in order to study Venus’s seismic activity. Recorders on a “floatilla” above the planet’s surface could listen into Venus-quakes and reveal Venus’s mysterious past. And closer to home, s

In the decade since the genome editing capabilities of CRISPR-Cas9 emerged, research into novel medicines has boomed – but alongside progress comes new ethical considerations. Controversy erupted in 2018, when Chinese scientist He Jiankui created the first babies with edited genomes. After leaving prison last year, he’s now back in the lab trying to raise support for new research but refuses to discuss the ethical implications of his work. Dr Joy Zhang recently arranged a bioethics seminar and invited He Jiankui, it was the first time he’d agreed to engage with a global cohort of CRISPR scientists since returning to his research.Going back in time from cutting-edge to ancient technology, some of the oldest stone tools ever used by human ancestors have been unearthed at a fossil site in Kenya. Professor Tom Plummer talks us through the findings and how important the tools were in our evolution.And we immerse ourselves in the mysterious sounds of the Arctic and Antarctic, from singing ice to the man-made noises

In the early hours of Monday, a powerful earthquake hit Kahramanmaras in Turkey. Nine hours later another struck. When this edition of Science in Action first aired, 19,000 people were reported to have died, but that number was expected to rise. Back in 2016, Professor Asli Garagon and her colleagues accurately predicted that an earthquake of this size was coming. Using GPS, they were monitoring the East Anatolian fault to calculate energy building between the plates. With such accurate insight could Turkey have been better prepared?Ross Stein, seismologist and founder of Temblor, a Californian consultancy that specialises in assessing hazard risk, estimates the plates moved at 5,000 mph. The movement of the plates may have built up pressure in other parts of the country. And finally, Tiziana Rossetto, a civil engineer at University College London, knows better than most that earthquakes do not kill, buildings do. She tells Roland how the combination of earthquakes and subsequent aftershocks appear to have ev

Pull on an extra layer and stay toasty whilst Science in Action braces for a deep freeze. Whilst we know plenty about the ice on the Earth’s poles, Roland is on a chilling journey to see what can be found in deep space. Professor Christoph Salzmann and Professor Andrea Sella at University College London have produced a new phase of ice. Roland heads to the laboratory to see how the usual crystalline ice, found in ice cubes and icebergs, can be broken down and arranged into a new structure. The James Webb Space Telescope has detected the coldest ices to date, deep within a molecular cloud in outer space. Professor Melissa McClure describes how these clouds harbour a variety of different molecules potentially capable of forming the basic building blocks for life. From the edges of the universe to something a little closer to home, Professor Geoff Collins and colleagues have discovered odd tectonic plate activity on icy Europa, one of Jupiter’s moons. And a theory for the origin of life that may su

An outbreak of pathogenic bird flu, H5N1, in a Spanish mink farm could be a cause for concern. Some experts fear the virus may now spill over to other mammals without strict surveillance. Marion Koopmans, professor of virology at Erasmus Medical Centre, talks Roland through the potential risks. India’s caste system affects all aspects of society, but how does the hierarchy influence representation of marginalised groups in academia? Science journalist Ankur Paliwal believes that, despite efforts to combat discrimination, not enough is being done, and he has the data to prove it. Imagine a robot... Is it hard, metallic and humanoid? Professor Carmel Majidi from Carnegie Mellon University and his colleagues are thinking outside the robotics box. Their new material, magnetic in nature, can shift between solid and liquid states. It’s even capable of breaking out of robotic jail... And how do echidnas – spiny, long-nosed, egg-laying mammals – manage to stay cool during the hot Australian summers? Ima

Climate researcher, Rose Abramoff took to the stage at the American Geophysical Union (AGU) fall meetings, not as a guest speaker but in protest. Whilst her demonstration only lasted 15 seconds, she found her employment terminated from Oak Ridge National Laboratory and research stripped from the AGU programme. She was attempting to persuade other climate scientists to ‘get out of the lab and into the street’. Whilst Rose’s protest hit the headlines in the media, potentially less attention was paid to the session that was taking place at the conference, hosted by Mika Tosca, climate scientist-turn-artist, Associate Professor of Liberal Arts at the School of the Art Institute of Chicago. Roland brings the two together to discuss the event and how climate scientists should approach activism. Although there is no one solution to the climate crisis, Roland loves a brainstorm on Science in Action. Climate activist Stuart Capstick, a Cardiff University psychologist specialising in public attitudes to environmental i

Flood warnings in parts of California have seen some of the state’s best known celebrities flee their homes. The current weather conditions are in part the result of ‘Atmospheric rivers’ – literally fast flowing rivers of water vapor in the atmosphere. Marty Ralph from the Scripps Institute has been studying this phenomenon for years, he explains what atmospheric rivers are, and tells us how a greater understanding of the phenomenon is now informing weather forecasting and evacuation plans.Over the past year several million people have fled Ukraine, amongst them many scientists. Nataliya Shulga from the Ukraine Science Club is working on a wide ranging initiative to attract them back. She tells us of plans not just to reconstruct Ukrainian science facilities after the war, but to offer a philosophical change which breaks with the Soviet past - a more global, collaborative environment for scientists returning to the Ukraine. Last December the Afghan Taliban banned women from attending university, its just o

We’re taking a look back at the January 2022 eruption of Hunga Tonga-Hunga Ha’apai, which literally sent shockwaves around the world. One year on, and we’re still uncovering what made the volcano so powerful, as well as unpacking its long lasting impacts.Roland is joined by Professor Shane Cronin from the University of Auckland and Dr Marta Ribó from the Auckland University of Technology to share their findings from their latest trip to survey the volcano.The impacts of the eruption weren’t just felt on Earth – they also reached all the way to space. Physicist Claire Gasque from the University of California, Berkeley, has been analysing how the eruption affected space weather.Amongst all the material ejected by Hunga Tonga was a huge amount of water. The massive water vapour cloud is still present in our atmosphere, as Professor Simon Carn from the Michigan Technological University tells us.The volcano also triggered tsunamis worldwide. Disaster sociologist Dr Sara McBride from the US Geological Survey has be

Nasa's James Webb Space Telescope has produced amazing images, and amazing science, in its first five months. Roland Pease hears from one of the leading astronomers on the JWST programme, Dr Heidi Hammel, as well as other experts on what they are already learning about the first galaxies in the Universe, the birthplaces of stars, the strange behaviour of some other stars, and the first view of Neptune's rings in over 30 years.Producer: Roland Pease Assistant producer: Sophie Ormiston Image: An image from the James Webb Space Telescope (Credit: Nasa via PA)

Mosquito pesticide failing - prevention of dengue fever and other diseases at risk. Dangerous bird flu evolving fast - researchers are learning why bird flu is persisting and spreading fast round the world, and assess the threat to humans. Drilling for ancient ice in the Antarctic - Roland talks to one of the team drilling kilometres into an ancient, frozen record of past climate, Martian rock store opens - NASA's Mars Perseverance rover is stashing rock samples future missions could bring back to Earth.Image credit: Shinji KasaiProducer: Roland Pease Assistant Producer: Sophie Ormiston

Fusion milestone - the science behind the headlines. Laser fusion expert Kate Lancaster walks us through the technology that produced energy gain at the US's National Ignition Facility NIFWhirlwinds on Mars What the sounds of a dust devil passing over NASA's Mars Perseverance Rover tells us about the Martian atmosphere75 years of the transistor electronics revolution - where next for Moore's Law? December 16th 1947 was the day the first ever transistor device passed an electrical current. Trillions are made every day these days, powering our interconnected world. Roland recalls meeting some of the pioneers for the 50th anniversary, including Gordon Moore, and hears from Berkeley Dean of engineering Tsu-Jae King Liu how the revolution will continue for another 25 years.

Two-million-year-old molecular fossils reveal flourishing woodlands and widespread animals in Greenland's pre-Ice-Age past, and give hints to the Arctic’s future under global warming. We hear from a molecular palaeontologist and a climate modeller.DNA also reveals the enduring genetic influence of our extinct Denisovan cousins on disease immunity in modern island South East Asians.And the art and science of 3D-printing violinsProducer: Roland Pease Assistant producer: Sophie Ormiston(Image: Landscape illustration with three elephants. Credit: Beth Zaiken/bethzaiken.com)

Hong Kong health expert Professor Malik Peiris relates the lessons from the devastation there earlier this year. UK virologist Dr Tom Peacock reveals the unusual origins and evolution of omicron, and explains the risks of dangerous new variants. New studies from China are revealing further SARS-like viruses in the wild; Professor Eddie Holmes says they underline the risk of further pandemics.(Photo: Kevin Frayer/Getty Images)

Nasa's JWST space telescope has unpicked the chemical contents and state of the atmosphere of planet WASP-39b 700 light years away. Astronomer Hannah Wakeford explains. Meteorologist Laura Wilcox warns that atmospheric haze over China and South Asia is masking some of the effects of global warming.Loss of memory and other mental changes during pregnancy have been traced to structural changes in the brain, possibly due to hormone effects. Neuroscientist Elseline Hoekszema speculates.Improving lab coats - every scientist has a lab coat, but how many have one actually fits? Founder of Genius Lab Gear Derek Miller explains the problem and how he's trying to fix it.Producer: Roland Pease Assistant producer: Sophie Ormiston(Photo: View of Earth from space. Credit: Melissa Weiss/Center for Astrophysics/Harvard and Smithsonian)

Since the Covid-19 pandemic began, scientists studying the virus have become targets of online harassment, and more recently, death threats. Roland speaks to Dr Angela Rasmussen, virologist at the Vaccine and Infectious Disease Organization at the University of Saskatchewan, about her experiences.Spyros Lytras, PhD candidate at the University of Glasgow, talks Roland through the evolutionary history of the virus that causes Covid-19 and how there isn’t just one ancestor, but several. Anti-Asian sentiment has seen a big increase since the pandemic. Dr Qian He, Postdoctoral Research Associate at Princeton University, looked into how US-China relations have influenced how Americans view Chinese today.And we hear from scientists on board the RRS Discovery, which is currently located near St Helena and Ascension Island, surveying the health of the surrounding ocean. On board, documentary film-maker Lawrence Eagling, talks to Shona Murray, pelagic ecologist from the University of Western Australia, and Gareth Flint

Researchers have identified which neurons, when electrically stimulated, can restore the ability to walk in paralysed patients. Professor Jocelyne Bloch, Associate Professor at the Université de Lausanne, tells Roland how the technology works.Astronomers have discovered the closest black hole to Earth. Researchers led by Kareem El-Badry, astrophysicist at Harvard University, identified the celestial body when they spotted a Sun-like star orbiting a dark, dense object.The origins of eels have been mystifying scientists for centuries. Though the Sargasso Sea has been their presumed breeding place for 100 years, there has been no direct evidence of their migration – until now. Ros Wright, Senior Fisheries Technical Specialist at the Environment Agency, shares how researchers finally pinned down these slippery creatures.This week, a new report from the UN Environment Programme reveals that carbon dioxide emissions from building operations have reached an all-time high. Insaf Ben Othmane, architect and co-author o

The Congo Basin is home to the world’s largest peatland. Simon Lewis, Professor of Global Change Science at UCL and the University of Leeds, tells Roland how this peatland acts as a huge carbon sink and how climate change could result in these carbon stores being released. He is joined by Dr Ifo Averti, Associate Professor in Forest Ecology at Universite Marien Ngouabi in the Congo who helps us understand what this landscape is like. We explore how peatlands all around the world are showing early alarm bells of change. From the boreal Arctic forests to the Amazon, prof Simon Lewis helps us understand how they could action huge change in the climate. Hurricane Ian, which recently caused devastating damage to Cuba and the United States, may signify a growing trend of increasingly powerful storms. Karthik Balaguru, climate and data scientist at the Pacific Northwest National Laboratory, explains how climate change is causing hurricanes to rapidly intensify, making them faster and wetter.On Sunday 6 November, CO

The latest observations from Nasa’s InSight Mars Lander and Mars Reconnaissance Orbiter (MRO) have revealed new information on Mars’ interior structure. Dr Anna Horleston, Senior Research Associate in Planetary Seismology at the University of Bristol, talks us through the mars-quakes that provided this data. On the 30th of October, Brazilians will head to the polls to elect their next president. Jeff Tollefson, Senior Reporter at Nature, tells Roland what approach the two candidates – Jair Bolsonaro and Luiz Inácio Lula da Silva – might take towards science and the potential local and global impacts this could have.Humans aren’t the only animals to pick their noses… it turns out primates engage in this habit too. Anne-Claire Fabre, Curator of Mammals at the Duke Lemur Center, tells reporter Vic Gill about the long-fingered aye-ayes having a dig around their noses, and how more research is needed to unpick the reasons behind this behaviour.And producer Robbie Wojciechowski heads to the National Oceanography Ce