Science In Action

A large system of ocean currents known as the Atlantic meridional overturning circulation (AMOC) has been making headlines this week as a new paper predicts its imminent collapse. This could have devastating consequences for the climate. But not all climate scientist and oceanographers are convinced by the results. Stefan Rahmstorf and Eleanor Frajka-Williams debate the contentious paper.In more positive news, huge steps have been made in the field of gene therapy. Stefano Rivella and Hamideh Parhiz tell us about their incredible mRNA delivery technology which could take much of the cost and risk out of treating debilitating disordersAnd as wildfires continue to blaze around the world, reporter Melanie Brown discovers how experts study the physics of these blazes from the Missoula Fire Sciences Laboratory. Presenter: Roland Pease Producer: Ella Hubber Editor: Richard Collings

For the third year running, Iceland’s Reykjanes peninsula is experiencing another spectacular volcanic eruption. Volcanologist Evgenia Ilyinskaya has been out in Iceland witnessing the sight and getting samples of the noxious fumes. Across the rest of the Northern Hemisphere heat domes persist, bringing extreme weather ranging from wildfires to tornadoes. We keep on seeing that this year “is the warmest in 120,000 years”. But what does that mean? Two paleoclimatologists, Bette Otto-Bliesner and Jessica Tierney tell us more.And we’re going deep. Deep into the brain that is, with a newly-developed probe which is finer than a baby’s hair. Dr Anqi Zhang of Stanford University explains her delicate technology. Finally, new research suggests that SARS-CoV-2 could have arisen in the wild no more than four years ago, a mishmash of other viral genomes. Bioinformatician Jonathan Pekar discusses his new paper.Presenter: Roland Pease Producer: Ella Hubber Editor: Richard Collings(Photo: Dr. Evgenia Ilyinskaya Credit: @E

As extreme heat returns to much of the world we hear the impact of last year’s heatwaves in Europe, where 62,000 people are estimated to have died. Joan Ballester, Associate Research Professor at Barcelona Institute for Global Health, discusses the figures from his latest paper and his concerns for the future. This week the European Court of Human Rights ruled in favour of middle-distance runner and Olympic champion Caster Semenya in a case related to testosterone levels in female athletes. Marnie Chesterton speaks to developmental biologist Dr Emma Hilton about what causes differences in sexual development and the impact they can have.Also, Kew Gardens is going digital. Millions of specimens are being made available to the world for the first time in an enormous digitisation project. Ella Hubber goes behind the scenes at Kew to see some of the precious specimens. Finally, the Indonesian government has banned a group of foreign scientists from conducting conservation research. Bill Laurance, Research Professo

Record-breaking global temperatures are accelerating Greenland ice melt at an alarming rate. Professor of glaciology Alun Hubbard has witnessed the melt first hand. He tells us how the ice sheet is being destabilised and what this could mean on a human level. Also, how safe are Japanese plans to dispose of nuclear waste from the Fukushima accident? We get reassurance from molecular pathology expert, Professor Gerry Thomas. And last week was a big one for cosmology news. We catch up on science behind the gravitational hum that permeates the Universe with astrophysicist with Dr Chiara Mingarelli. And we hear about the traces of ghostly neutrinos within our Galaxy from the principal investigator of the world’s largest neutrino detector, Professor Francis Halzen. Presenter: Roland Pease Producer: Ella Hubber(Photo: Meltwater forming on top of the Russell Glacier, Greenland)

We have entered a “permacrisis”, an extended period of instability and insecurity, fuelled not only by natural disasters but pandemics, climate change and war. This week, Science in Action is at the Royal Society as they host the All European Academies assembly on the importance of research in crises. Roland speaks to international experts on how research contributes to responding to and preparing for the multiple and entangled crises of our time. Presenter: Roland Pease Producer: Ella Hubber Editor: Richard Collings Production co-ordinator: Jonathan Harris (Photo: A man wearing a protective face mask walks past an illustration of a virus in Oldham, 3 August 2020 Credits: Phil Noble/Reuters)

Over the last week, news of “synthetic human embryos” has made headlines around the world. Science in Action is getting to the bottom of the sensational story. We talk to two of the researchers who have made the embryo models from stem cells in their labs; Professor Magdalena Zernicka-Goetz from the University of Cambridge and California Institute of Technology, and Professor Jacob Hanna from the Weizmann Institute of Science in Israel. They tell us how they made the embryo models, what their aims are, and their own ethical considerations. The scientific community is excited, but not surprised, by the breaking research. We hear how Dr Andreia Bernardo, group leader at Imperial College London, could use these structures in her future research. Finally, Director of the Reproductive Sociology Research Group at Cambridge University, Professor Sarah Franklin, and Professor of Law at Stanford University, Hank Greely, tackle the legal and ethical constraints on this kind of work, and why it is important for unde

As Pacific Ocean temperatures rise, a major El Niño is looming. Experts from the European Centre for Medium range Weather Forecasting, Magdalena Balmaseda and Tim Stockdale, join us to discuss how it is heating up the world and if it could herald in a new period of climate uncertainty.Last month, Roland stayed up all night to watch the spectacular explosion of supernova 2023ixf. Now, Dr Charlie Kilpatrick, a postdoctoral fellow at Northwestern University, has identified the star that blew up 21 million lightyears away. A similar star in our galaxy, the exceptionally bright Betelgeuse, has been acting strangely. Dr Andrea Dupree, a senior astrophysicist at the Center for Astrophysics, Harvard and Smithsonian, has been trying to figure out what is going on. Is this iconic star about to pop?And from ageing stars to ageing flies, researchers have published a cell-by-cell map of fruit flies throughout the life of the short lived creatures, showing how they change. Steve Quake, professor of bioengineering and profe

The origin of all complex life has been traced back 1.6 billion years as new molecular fossil records have discovered the fatty stains that our ancient single celled ancestors have left behind. Jochen Brocks, Professor of Geobiology at Australian National University, discusses the significance of these unique biological signatures. One billion years later, to a mere 462 million years ago, life on Earth was experiencing a boom of new species but we have very few fossil records to understand this era. Now, palaeontologists Dr Joe Botting and Dr Lucy Muir have found the most abundant deposit of soft bodied fossils from this time in a tiny Welsh quarry. Next, to the relatively recent past, 350,000 years ago, where remains found in a South African cave suggest that an extinct species of human, Homo Naledi, buried their dead. But Mike Petraglia, Professor of Human Evolution and Prehistory at the Max Planck Institute, doubts these claims. And in the modern day, the fungi which have colonised our soil for millions

The California Condor has been brought back from the brink of extinction by dedicated conservation efforts over the past 30 years. Now, this critically endangered species is the latest victim of the H5N1 bird flu which is racing round the world. California Condor co-ordinator Ashleigh Blackford and wildlife veterinarian Dr Samantha Gibbs from the US Fish and Wildlife Service discuss their last-ditch efforts to vaccinate the birds against H5N1.Huge 40,000 km plumes of water ice have been imaged erupting from Saturn’s moon Enceladus. Dr Sara Faggi, a postdoctoral Researcher in the Solar System Division at Nasa Goddard Space Flight Center, dives into this incredible new observation from the James Webb Space Telescope. Dr Pierre Galand from France’s Observatoire Océanologique de Banyuls has been part of a two-and-a-half-year expedition to sample the microorganisms in coral reefs across the world. His new research shows that this tiny life is much more diverse than previously understood and may be essential to lif

A star in the nearby Pinwheel Galaxy has exploded spectacularly into a supernova, dubbed SN 2023ixf. It is the brightest in a decade and it has got astronomers around the world into a frenzy. Science in Action hears from both amateur and professional astronomers alike as they scramble to collect exciting new images and data. Back on the ground, we hear from the Professor of Climate Change and Earth System Science at the University of Exeter, Tim Lenton about his new paper highlighting how rising global temperatures could push human populations from their homes.Contributors: Dan Milisavljevic, Assistant Professor in the Department of Physics and Astronomy, Purdue University. Dr Jane Clark, Trustee of the Cardiff Astronomical Society Bronco Oostermeyer, amateur astronomer Raffaella Margutti, Associate Professor in the Department of Physics and Astronomy, University of California, Berkeley Erez Zimmerman, Astrophysics PhD student, Weizmann institute of science Professor Avishay Gal-Yam, Head of Experimental A

Over the past few weeks, wildfires have scorched over 1,800 square miles of land across North West America and are still going strong. Dr Mike Flannigan, professor at the Department of Renewable Resources at the University of Alberta, talks to Roland about the weather patterns and record-breaking heat causing the devastating flames. On the other side of the world, in Zambia, Dr Edgar Simulundu has been finding out why some humans attract mosquitoes more than others, and how we can use this to tackle the malaria epidemic. Also this week, Professor Novel Chegou, lead investigator at Stellenbosch University Immunology Research Group, has been awarded the 2022 Africa Prize for his innovative method for quickly diagnosing tuberculosis. And we visit the Royal Society for a very different reason. Roland checks in on the “Ukraine's Recovery: Rebuilding with Research” conference, and the discussion to use evidence based approaches for rebuilding after war. Contributors:Dr Mike Flannigan, Department of Renewable Resou

In 2003, an incredible scientific milestone was achieved as the first human genome completed sequencing. For 20 years, this genome has been used as a reference by researchers for comparison to all other DNA sequences. Now, the Human Pangenome Reference Consortium is addressing the lack of genetic diversity starting with 47 new reference genomes. Members of the consortium, Dr Karen Miga, assistant professor, UC Santa Cruz Genomics Institute and Dr Benedict Paten, associate professor, UC Santa Cruz Genomics Institute, join Roland to discuss the first stages of the project. For the first time the public will have access to thousands of documents from the Royal Society’s historical collections following their digitisation. Science correspondent Vic Gill visits the vaults to see some of these pieces of history first hand. We are also taking a trip 30km above the Earth, to the stratosphere, where Daniel Bowman, principal scientist from Sandia National Laboratories, is using solar powered balloons to listen to

India is at the centre of much of the discussion on this week’s episode of Science In Action. We hear about how a proposal to scrap Darwinian evolution from Indian secondary schools has led to signatures from thousands of scientists. Dr Vineeta Bal, Researcher at the National University of Immunology, is one of the signatories on a petition against the proposed changes. We spoke to her about why she is against them.Also in India, a new Sars-Cov-2 variant, named XBBX.16 is being studied by epidemiologists in the country. Dr Rajesh Karyakarte, professor of microbiology at BJ Government Medical College, Pune, India, is behind the study. Further study of the variant has been looked into by Kei Sato, professor of Systems Virology at the University of Tokyo. Kei has been mapping how new variants could cause us problems, ahead of them doing so. This kind of forward planning is something praised by Paul Bienaisz, Professor of Virology at The Rockefeller university. We talk to him about how vital this kind of work st

Khartoum’s National Public Health Laboratory has been caught up in the ongoing conflict in Sudan. Dr Maysoon Dahab and Dr Ayman Ahmed explain the situation and why health labs are often targeted in conflicts.Virus hunters have used artificial intelligence to discover more than 180,000 new viruses. Professor Eddie Holmes and Dr Mang Shi tell Roland how AI is completely transforming the field of viral discovery.Experts have forecasted a return to El Niño conditions later this year, which could bring with it extreme weather events. Dr Emily Becker explains how the predictions are made and the global impact of a strong El Niño.And from future to historical weather – Roland talks to Professor Ed Hawkins about the powerful Storm Ulysses of 1903, and how it can help us better understand storms today.Presenter: Roland Pease Producer: Roland Pease Assistant Producer: Sophie Ormiston

The pandemic showed Africa at the back of the global queue when it came to vaccines. That should never happen again if plans being debated in Cape Town this week go ahead. Roland talks to Seanette Wilson of South Africa's Biovac.Also in the programme: life finds a way on plastic floating in the ocean; Greenland rock dust as a global fertiliser; and designing proteins from scratch.Image Credit: Robert Bonet/NurPhoto via Getty ImagesPresenter: Roland Pease Producer: Roland Pease Assistant Producer: Sophie Ormiston

H5N1, a highly pathogenic avian flu is racing across the world, and has infected multiple species, including wild and farmed birds, and mammals from cats to sea lions. What can be done to control it? Roland Pease talks to global experts about the dangers to animal and human health, and about the measures to bring the outbreak under control.Producer: Roland Pease Assistant producer: Sophie Ormiston(Photo: A government worker examines chicks for signs of bird flu infection at a poultry farm in Darul Imarah in Indonesia's Aceh province. Credit: Chaideer Mahyuddin)

Chasing tornados in the American mid-West – scientists are trying to learn the maximum from the tornado outbreaks currently in America. Professor Karen Kosiba calls us from a radar truck studying the storms, and Professor John Allen explains the energy powering them. From the weather of today to the skies of 800 years ago... Dr Sébastien Guillet reveals how lunar observations by medieval monks are helping untangle the connection between historic eruptions and climate. Finally, we go back even further in time to the Bronze Age with Professor Elisa Guerra-Doce – to find out what drugs our ancestors were into. Image credit: Getty Images / Michael B. Thomas Producer: Roland Pease  Assistant Producer: Sophie Ormiston

We look at a gene editing breakthrough, a new technique to correct genetic errors in sick patients. Roland speaks to Professor David Liu to learn about the base editing technology.Also, we look into the complex causes of last year's post-pandemic spike in child hepatitis. Professor Judy Breuer and her colleagues may have found an explanation behind the unexpected outbreak.And the James Webb Space Telescope continues to seek out the secrets of our universe. Professor Beth Biller and Dr Elsa Ducrot have the details on the atmospheres of two very distant, and very different, exoplanets.Plus, how to get sober – for mice. Professor Steven Kliewer explains how certain mammals have evolved to deal with the intoxicating effects of ethanol. Producer: Roland Pease Assistant Producer: Sophie Ormiston(Image: Genetic engineering 3D rendered conceptual image. Credit: Getty Images)

DNA has revealed potential animal COVID carriers at the Wuhan market, but what does that tell us about the start of the pandemic? Roland talks to two of the experts behind the new analysis: Dr Florence Débarre and Professor Eddie Holmes.Also, we look into Europe’s grand new space ambitions. ESA director general Josef Aschbacher gives Roland the details of the space agency’s out-of-this-world plans.And Beethoven's last DNA: a hairy story of his family and genetic afflictions. Dr Tristan Begg shares how the composer’s tresses unlocked new information about his life and death.Image credit: Eddie HolmesProducer: Roland Pease Assistant producer: Sophie Ormiston

34 days after it first formed at the far end of the Indian Ocean, record-breaking Cyclone Freddy made a repeat landfall on Mozambique as well as passing over Malawi, causing extensive damage and loss of life. Climate scientists Liz Stephens and Izidine Pinto join Roland to give an update on the destruction and explain how Cyclone Freddy kept going for an exceptionally long time.At the Third International Human Genome Summit in London last week, Professor Katsuhiko Hayashi announced he had created baby mice from eggs formed by male mouse cells. Dr Nitzan Gonen explains the underlying science, whilst Professor Hank Greely discusses the ethics and future prospects.And from one rodent story to another, SARS-CoV-2 has been detected in brown rats scurrying around New York sewers. Dr Thomas DeLiberto from the US Department of Agriculture gives Roland the details.Image credit: Jack McBrams/Getty ImagesProducer: Roland Pease Assistant Producer: Sophie Ormiston