Future Science Group

Mitigation strategies for the biological matrix supply chain: an interview with Mark O'Dell by Future Science Group

In this episode, supported by Zymo Research, guest host Georgia Bickerton explores NGS data and how bioinformatic pipelines and workflows can be optimized to make NGS data more accessible. To do this she speaks with Jeffrey Bhasin, Director of Informatics at Zymo Research, who discusses the key issues of reproducibility in bioinformatics, the selection of methods available to analyze different datasets and to investigate different aspects of these data. Listen today to discover the techniques available to help increase the portability and reproducibility of fine-tuned bioinformatics workflows and to streamline the application of these workflows. Bhasin also reveals how these 'workflow management' technologies can enable more global, collaborative approaches to bioinformatics workflow construction and begin to increase the automation and accessibility of bioinformatics workflows. Contents: Introduction: 00:00-00:55 How the rise of NGS has impacted the field of bioinformatics: 00:55-01:35 Issues of reproduc

ADA assay development: a podcast interview with Lynn Kamen by Future Science Group

The key diagnostic and prognostic information locked away in cell-free nucleic acids (cfNAs) has become increasingly accessible due to developments in genetic and epigenetic profiling techniques. These advances have engendered the rise of liquid biopsy techniques, which capture and analyze cfNAs from samples such as blood, saliva, urine and feces, in diagnostics and basic disease research. However, challenges remain in the detection and analysis of these nucleic acid fragments, in part due to their low abundance and fragile nature. In this episode, Ayla Maunighan-Peter, Epigenetics Product Specialist at Zymo research (CA, USA), details the utility of these molecules, the challenges associated with their development and implementation of liquid biopsies and their use in both basic research and diagnostic spaces. For an insight into how cfNAs can be used to identify novel drug targets, impact diagnostics development and be used to help soothe the organ shortage crisis, listen today! Contents: Intro: 00:

The key diagnostic and prognostic information locked away in cell-free nucleic acids (cfNAs) has become increasingly accessible due to developments in genetic and epigenetic profiling techniques. These advances have engendered the rise of liquid biopsy techniques, which capture and analyze cfNAs from samples such as blood, saliva, urine and feces, in diagnostics and basic disease research. However, challenges remain in the detection and analysis of these nucleic acid fragments, in part due to their low abundance and fragile nature. In this episode, Ayla Maunighan-Peter, Epigenetics Product Specialist at Zymo research (CA, USA), details the utility of these molecules, the challenges associated with their development and implementation of liquid biopsies and their use in both basic research and diagnostic spaces. For an insight into how cfNAs can be used to identify novel drug targets, impact diagnostics development and be used to help soothe the organ shortage crisis, listen today! Contents: Intro: 00

In this Tech Blast episode, we discuss preclinical models of non-alcoholic fatty liver disease with Gareth Guenigault, Lead Scientist of Services at CN Bio (Cambridge, UK). Gareth provides an overview of non-alcoholic steatohepatitis (NASH) therapeutic landscape and explains how incorporating organ-on-a-chip models into drug discovery workflows can improve this landscape. Get Gareth’s expert insight into the field and discover how to develop liver-on-a-chip NASH models, tips for analyzing the resultant data, and the future of organ-on-a-chip technologies. Contents: Introduction: 00:00–00:30 Pathology and prevalence of NASH: 00:30–01:50 Challenges faced when developing drugs for NASH: 01:50–03:40 An overview of organ-on-a-chip models: 03:40–05:05 Liver-on-a-chip models for NASH: 05:05–07:05 Incorporating organ-on-a-chip into drug discovery workflows: 07:05–08:45 Accessing liver-on-a-chip and NASH models: 08:45–09:45 The NASH-in-a-box workflow: 09:45–10:45 Gareth’s tips for analyzing the data: 10:45–12:15 The

FON-2021-1277 OCTalks by Future Science Group

In this episode, we discuss recombinant proteins: what are they and what are they used for? BioTechniques Editor Tristan Free speaks to Amy Sheng, Technical Account Manager at Sino Biological, who explains the history of recombinant proteins and how protein modeling techniques such as AlphaFold are changing their development. Find out how monoclonal antibodies have been used through the COVID-19 pandemic and how we may overcome challenges in production, upscaling and more in this episode of Talking Techniques.  Contents:Introduction 00:00-01:26What are recombinant proteins and what are they used for? 01:26 – 02:42How were they first developed? 02:42 – 03:50Since initial development has recombinant antibody development progressed today? 03:50 – 05:57What are the advantages of utilizing the more traditional mouse monoclonal antibodies? 05:57 – 07:11Are recombinant antibodies used in more specialist applications and are they more likely to be used in therapeutics? 07:11 – 09:47How have AI systems like

In this Tech Blast episode, we discuss generating, standardizing and sharing microbiome data with Raul Cano, Chief Scientific Officer at The BioCollective. Raul provides a brief overview of the reproducibility crisis and explores how the use of standards and databases can address the challenges it poses. Get Raul’s insight into the field and discover the steps that can be taken to make microbiome research accessible and reproducible. Contents: Introduction: 00:00–00:40 Overview of the reproducibility crisis: 00:40–02:25 The importance of standards for microbiome data: 02:25–05:05 Sharing microbiome data: 05:05–07:10 Comparing microbiome databases: 07:10–08:20 The significance of metadata: 08:20–08:50 How databases can enhance the use of standards: 08:50–10:05 Databases help standardize microbiome research: 10:05–10:45 Benefits of sharing data: 10:45–11:40

In this '3D and tea' interview, we speak to Dolores Serrano and Katerina Lalatsa all about the potential of utilizing 3D printing in cancer studies.

NCTalks with Jan Hillert: pregnancy outcomes in MS by Future Science Group

Flow cytometry for CGT assay development: an interview with Richard Cuthbert by Future Science Group

In this podcast, Andrew Hall (Labcorp, UK) discusses the evolution of large molecule bioanalysis workflow automation as well as the present challenges facing the industry.

Bioanalytical assays for gene therapy programs: an interview with Catherine Vrentas by Future Science Group

In this episode, supported by Zymo Research, we discuss the epigenetic clock: what is it? How are researchers using it and what are some of the key tools available to study it? Elucidating the link between epigenetics and aging is Keith Booher, Director of Services at Zymo research including aging and epigenetics research services. Keith reveals how our behaviors and environment, such as diet, exercise and air quality, can impact our epigenetics and the impact that the epigenetic clock has played in the development of new therapeutics. Find out how you can reverse your biological age, the implications of aging populations the latest developments in epigenetic research and more in this episode of Talking Techniques.  Contents: Introduction: 00:00-02:15The issue with population aging: 02:15-03:30Introducing epigenetics:  03:30-04:20The link between epigenetics and aging: 04:20-05:50The impact of exercise on epigenetics: 05:50-06:40The epigenetic clock: 06:40-08:00What can the epigenetic clock tell

ddPCR for CGT quality control: a podcast with Mark White by Future Science Group

In this podcast Barry Jones (Director, LC–MS Biologics and Biomarkers at Q² Solutions) and Adriane Spytko (Manager, LC–MS Biologics at Q² Solutions; both NY, USA) discuss hybrid assays using both LBA and LC−MS techniques. They share their thoughts on bottom-up LC−MS methods and the concern about detecting analyte that is not intact as well as future projects that bridge LC−MS and LBA.

In this episode of Talking Techniques, supported by Resolve BioSciences, we explore the realm of spatial biology, with a particular focus on the techniques involved in this approach to biological exploration, and the exciting insights gleaned from these techniques that have led to this approach being labeled Natures Method of the year 2020!  Stefano Pupe, Postdoctoral Researcher at German Center for Neurodegenerative Diseases, takes me through this field, revealing – amongst other fascinating insights – the neuroscience studies that can now be conducted on live mice to monitor their neurological cell expression profiles as they perform specific behaviors. We also discuss the potential immortality complexes that could be driving a large amount of investment into the field and highlight some of the challenges to watch out for when conducting spatial biology studies. ContentsIntroduction 00:00-02:20 The concept of spatial biology 02:20-03:30 The key techniques involved in spatial biology: 03:30-0

In this episode of Talking Techniques, we introduce a new podcast series, produced by BioTechnques and hosted by the enigmatic Antentor Othrell Hinton Jr, Assistant Professor of Molecular Physiology and Biophysics at the Vanderbilt University, and bring you a sneak peek of the first episode of the series. In this podcast series, Antentor will discuss all things diversity, equity and inclusion in STEM, meeting with different guests each episode from across the spectrum of fields and people in the research community. Each episode will keep science at its core, exploring each guest's research and finding out how they encourage open and productive environments in their working communities. In episode one, dive into the discussion around mentoring practices and with our first guest, Christina Termini Assistant Professor a the Fred Hutch Cancer Research center (CA, USA) Contents: Introduction: 00:00-02:40 Christina's Research in hematopoietic stem cells and cancer treatments. 02:40-05:45 Molecular regulators of

In this episode, supported by BioRad, we explore cell proliferation monitoring and its role in drug discovery, guided by the expert advice of Rachel Preston, Product Development researcher at Bio-Rad. We discuss techniques available to monitor cell proliferation, their advantages and disadvantages and the importance of selecting the right combination of techniques for different experimental targets. Rachel also provides some tips for best practice and some pitfalls to avoid regarding DNA damage and highlights the importance of good quality antibodies in cell proliferation assays. Don’t miss out on the most exciting applications of cell proliferation today, and find out what still needs to be improved for cell proliferation assays to continue driving drug discovery forward; all in the first episode of Season 3 of Talking Techniques! Contents: Intro: 00:00-00:34Why measure cell proliferation in drug discovery? 00:34-2:20Techniques involved in the detection of cell proliferation: 02:20-04:20The advantages an