Future Science Group

Organoids are transforming the way we approach the drug discovery pipeline. In this Tech Blast episode, Ritwika Biswas, Product Scientist at Sino Biological (Beijing, China), explains why drug discovery needs new methods and how organoids can help. Find out the importance of growth factors in the development of organoids for drug discovery, the challenges associated with their use and the impact of organoid biobanks on the field in this 15-minute overview of the landscape of organoids in drug discovery. Contents: Introductions: 00:00-00:28 Reviewing the drug discovery process: 00:28-02:45 Traditional methods used for target validation and drug screening: 02:45-05:20 Challenges associated with traditional methods: 05:20-07:00 How organoids can be used to address these challenges: 07:00-09:30 The importance of growth factors in organoid development: 09:30-10:50 Challenges in the utilization of organoids in drug discovery: 10:50-13:30 Organoid biobanks: 13:30-14:40 The impact of organoids in precision medi

In this Tech Blast episode, we discuss multiplex PCR methods, their challenges and advantages, and the tools being developed to advance multiplexing capabilities. Marco Bianchi, Product Manager at Bio-Rad Laboratories (CA, USA), provides an insight into what role multiplexing plays in research.

In this month's episode of Editor's Picks, we’ve got articles on magnetic synthetic cells, the synthesis of the most complete artificial microbiome yet and how a key protein in human fertilization was identified.

In this episode of the Talking Techniques podcast, we explore microbiomes and the techniques used to profile them. Get an overview of the different techniques’ working principles, their pros and cons and the different applications that they are best suited to. Providing an expert insight into this field is Annabelle Damerum, Microbiome R&D Scientist at Zymo Research. Annabelle reveals some key tips best practice when profiling the microbiome and details the importance of an emerging aspect of the field: the vaginal microbiome. Contents: Into: 00:00-01:50Why it is important to profile microbiomes. 01:50-04:15Key applications of microbiome profiling: 04:15-06:10Techniques used to profile the microbiome and their working principles: 06:10-09:20Targeted sequencing: 06:10-08:00Shotgun metagenomics: 08:00-09:00Metatranscriptomics: 09:00-9:15The strengths and limitations of these techniques: 09:12-             Targeted sequencing: 09:20-10.15Shot

As the cell and gene therapy industry expands further into commercialization, researchers, developers and manufacturers are growing increasingly aware of the need for specialized ancillary materials in the production of therapeutics. High-quality ancillary materials are often neglected during the early stages of development due to perceived cost, but conversion at later stages of development can be prohibitive and detrimental to program success.  In this podcast, in association with Sexton Biotechnologies (now part of BioLife Solutions; WA, USA), Steve Elimann of Orbsen Therapeutics (Galway, Ireland) and Steven Thompson of Sexton Biotechnologies discuss the challenges of variability in producing cell therapeutics, and how using consistent reagents from reliable manufacturers can tackle this challenge. We also dive deep into the importance of gaining and maintaining trustworthy partners early in your cell therapy journey and how this can influence the overall success of your final product.

In this special episode of Talking Techniques, brought to you from the Federation of European Neuroscience Societies Forum (FENS; 9th–13th July 2022), an expert panel discuss their research into the relationship between the gut–brain axis and addiction. The panel features Benjamin Boutrel (Lausanne University Hospital; Switzerland), Lorenzo Leggio (NIH Intramural Research Program; MD, USA) and Nathalie Delzenne (University of Louvain; Louvain-la-Neuve, Belgium), who discuss their current research into the role of the microbiota in alcohol addiction, if this work could be translated into the clinic, and if similar processes are at play in other addictions, such as food and cocaine. The discussion also features an audience Q&A, which explores the microbial relationship between mother and fetus, and social factors in addiction. Contents:Introduction: 00:00–01:35Introduction to panelists: 01:35–03:40Techniques being used to investigate the relationship between the gut and addiction: 03:40–0

In this Tech Blast episode, we discuss all things organoids with Ritwika Biswas, Product Specialist at Sino Biological US Inc (PA, USA). Ritwika provides an overview of what are organoids are, how reconbinant growths factors are utlized in their development, the benefits 3D organoid systems offer over 2D cell culture systems and the various applications organoids can be used for. Ritwika also explores the challenges that remain in organoid research and how these can be overcome, as well as what the future holds for these models. Contents: Introduction: 00:00–00:30 What are organoids? 00:30–01:05 Existing organoids: 01:05–02:00 Generating organoids and cell culture methods: 02:00–04:30 Applications of organoids: 04:30–06:10 Comparing 3D and 2D culture systems: 06:10–07:40 Reproducibility, matrigels and increasing complexity: 07:40–09:50 The future of organoids: 09:50–12:20

Hello and welcome to today’s latest episode of OC Talks Podcast by Oncology Central. My name is Jade Parker, Senior Editor of Oncology Central, and I am joined by Volkmar Mϋller from University Medical Center Hamburg-Eppendorf in Germany. Today we are going to discuss HER2-positive breast cancer including the unmet needs of the disease, and our hopes for the future.

In this Tech Blast episode, BioTechniques' Digital Editor, Annie Coulson, discusses single domain antibodies with ProSci’s Andy Lee, Lead Scientist of the Single Domain Antibody Program, and David Eling, Director of Business Development. Andy and David describe what single domain antibodies (sdAbs) are, including their unique characteristics, such as their small size. They then go on to explore the applications of sdAbs, from increasing resolution in imaging studies, to developing antidotes for snake venom. Listen to this episode to get an overview of sdAbs, how they could be incorporated into your research and their link to llamas. Contents: Introductions: 00:00–01:25 What are single domain antibodies? 01:25–3:05 Applications of single domain antibodies: 03:05–05:05 Unique characteristics of sdAbs: 05:05–07:55 sdAbs for SARS-CoV-2: 07:55–08:35 sdAbs for therapeutics and diagnostics: 08:35–11:25 Unique applications, including biosensors and animal feed: 11:25–12:50 Working with researchers to develop sdAbs:

In this Tech Blast episode, our Digital Editor Annie Coulson talks with Carlo Messina, Senior Director for Oncology in Global Development and Medical Affairs at Roche (Basel, Switzerland), about the use of comprehensive genomic profiling (CGP) in cancer research. CGP can obtain more information about a tumor from a smaller biospecimen compared with other genomic profiling techniques and gives oncologists more tools for treating patients. Carlo talks about the applications of CGP, including detecting genomic aberrations in the bloodstream, and the future of this technique.

In this episode, supported by BrandTech, returning guest Rob Vries, CEO of HUB organoids (Utrecht, The Netherlands), fills us in on the advancement of 3D cell cultures and organoids over the last 2 years, starting off by documenting how the pandemic impacted their development and uptake. We also discuss how the recent FDA Modernization Act, removing the requirement for drug candidates to be tested on animals, has impacted the drive for improved models, the key techniques available to analyze them and what still needs to change for 3D cell cultures to fully replace animal models in the lab. Listen today to find out which resources can help you begin to work with 3D cell cultures, their most exciting recent applications and how issues of reproducibility are currently being addressed in the field. Contents:Intro: 00:00-00:50How COVID-19 impacted the uptake and development of 3D cell cultures: 00:50-02:05Key developments in 3D cell culture technology in the last 2 years: 02:05-03:00Intestinal organoids and the

In this episode of Editor’s Picks, presented by guest-host Grace Tyrrell, learn about how the need for vaccine refrigeration could be on the way out, a new chemical approach that may aid in the fight against antibiotic resistance and the use of AI algorithms as a potential cure for drug-resistant epilepsy.

Welcome to OC talks, a podcast series exploring the latest advancements in oncology. I’m your host, Jade Parker, Oncology Central’s Senior Editor. In this episode, supported by Sengenics, we will be exploring the importance of autoantibodies in the development of cancer as well as how they can be used in the early detection of tumors. Joining me for this episode is Field Application Scientist Joseph Miseirvitch from Sengenics, a precision medicine company working to improve patient outcomes for physiologically relevant, data-guided decision making.

BZ PPD Spotlight Podcast: an interview with Cyrille Bonhomme by Future Science Group

In this episode of Talking Techniques, supported by Bio-Rad, we discuss a key component of many gene therapies: recombinant adeno-associated viruses (rAAVs) and their production. These viruses act as efficient, accurate delivery vesicles for the gene therapy’s plasmid. Speaking to Associate Director of Biopharma Product Marketing at Bio-Rad Laboratories, Mark White, we take a look the different expression systems used for their production and compare their advantages, before looking at some of the challenges involved in the production rAAVs, such as host cell contamination. Discover the tools that can help minimize host cell contamination and differentiate between nuclease resistant and nuclease reactive contaminant DNA and find out about some of the most exciting developments in rAAV technologies.   Contents:The role of rAAVs in gene therapies: 00:40-02:15 The production of rAAVs and gene therapies: 02:15-03:30 Why are HEK cells so popular for cell therapy production? 03:30-05:45 HEK vs

In this episode of Editor’s Picks, hosted by our Assistant Editor Aisha Al-Janabi, learn about recent concerns over the validity of a pivotal Alzheimer’s disease study, how researchers answered a question about the heart dating back to the 1600s and a laser-based diamond sensing technology that improves magnetoencephalography precision.

In many regions of the world, HPV and its association with cervical cancer is a well-known but rarely considered issue, after the rollout of the HPV vaccine in the late 2000s. However, while this rollout significantly impacted cervical cancer rates where it was implemented, it was not universal and in many areas of the world HPV induced cervical cancer remains a critical issue. Cervical cancer is the leading cause of death for people with a cervix living in poverty in low-resource regions and on the continent of Africa, it is estimated that in 2020 as many people with a cervix died of cervical cancer as COVID-19. In this episode of Talking techniques, supported by Oxford Nanopore, Senior Investigator Michael Dean and Post-baccalaureate Fellow Nicole Rossi, from the NIH’s National Cancer Institute (MD, USA), discuss their research into the relationship between HPV and cervical cancer. Expounding on the points mentioned above, they reveal the tremendous insights into cancer and immunology still to be gained,

Recently, the Alliance for Artificial Intelligence in Healthcare (AAIH) published "The Lifecycle of an AI System in Healthcare", a whitepaper defining what healthcare is and provides guidelines on implementing artificial intelligence (AI) and machine learning (ML) in this setting. In this episode of Talking Techniques, we speak with Oscar Rodriguez, a board member at AAIH and one of the authors of this whitepaper, to find out more about what the lifecycle of AI is, the importance of having guidelines when applying AI or ML in healthcare and what the future holds for this type of computer modeling. Contents: Intro: 00:00 - 00:45What are some of the ways that AI is used in healthcare? 00:45 - 5:04What are the current limitations of using AI in healthcare settings? 5:04 - 9:28The lifecycle of an AI system: 9:28 - 14:04How did you develop these guidelines for AI in healthcare? 14:04 - 17:28Summary of the guidelines from the white paper: 17:28 - 19:09Do you think some of these guidelines could be applicable to A

Recently, the Alliance for Artificial Intelligence in Healthcare (AAIH) published "The Lifecycle of an AI System in Healthcare", a whitepaper defining what healthcare is and provides guidelines on implementing artificial intelligence (AI) and machine learning (ML) in this setting. In this episode of Talking Techniques, we speak with Oscar Rodriguez, a board member at AAIH and one of the authors of this whitepaper, to find out more about what the lifecycle of AI is, the importance of having guidelines when applying AI or ML in healthcare and what the future holds for this type of computer modeling. Contents: Intro: 00:00 - 00:45What are some of the ways that AI is used in healthcare? 00:45 - 5:04What are the current limitations of using AI in healthcare settings? 5:04 - 9:28The lifecycle of an AI system: 9:28 - 14:04How did you develop these guidelines for AI in healthcare? 14:04 - 17:28Summary of the guidelines from the white paper: 17:28 - 19:09Do you think some of these guidelines could be applicable to A

Welcome to our newest podcast series, Editor's Picks, where we'll round up the latest life science news from BioTechniques. In this bitesize podcast, we've got everything from the history of cephalopods in neuroscience research to recent advancements against antibiotic-resistant bacteria.