Synopsis
Are you searching for stories to ignite your curiosity, teach you to perform better in life and career, inspire your mind, and make you laugh along the way? In this science podcast, Dr. Marie McNeely introduces you to the brilliant researchers behind the latest discoveries in science. Join us as they share their greatest failures, most staggering successes, candid career advice, and what drives them forward in life and science.
Episodes
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492: Investigating Novel Therapeutics to Improve Immune Function and Treat Age-Related Diseases - Dr. Joan Mannick
11/03/2019 Duration: 36minDr. Joan Mannick is Co-Founder and Chief Medical Officer of resTORbio, a clinical-stage biopharmaceutical company that develops novel therapeutics to treat aging-related diseases. Joan and her colleagues at resTORbio are targeting the biology of aging to treat and prevent aging-related diseases so people can be healthier longer. In particular, Joan is interested in targeting the aging immune system in an effort to reduce the risk of respiratory infections in older adults. After a busy day at work, Joan likes to relax by working out at the gym, watching movies, and reading novels. Joan received her B.A. from Harvard College and her M.D. from Harvard Medical School. She completed her residency in Internal Medicine at Brigham and Women’s Hospital and a fellowship in Infectious Disease at Harvard University. Joan then worked as a Medical Director at Genzyme and a faculty member at Harvard Medical School and the University of Massachusetts Medical School. Prior to joining resTORbio, Joan was Executive Director in
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491: Using Data to Inform Policy and Improve Quality of Life in Communities - Dr. Stephanie Shipp
04/03/2019 Duration: 44minDr. Stephanie Shipp is Deputy Director and Research Professor in the Social and Decision Analytics Division of the Biocomplexity Institute and Initiative at the University of Virginia. Stephanie works with social scientists and statisticians who are passionate about improving the quality of life for communities through data. They use data to inform policy-making and decision-making, working both at the scale of local communities and national projects. Stephanie develops methods and provides analyses to tell stories and answer questions using the massive amounts of data available today. When not at work, Stephanie enjoys cycling, pilates, running around with her grandchildren, and watching theatre performances with her sisters. Recently, she has also been having fun taking ballroom dancing classes with her husband. She received her B.A. Degree in Economics from Trinity College and her Ph.D. in Economics from George Washington University. Stephanie has previously held research positions at the Federal Reserve B
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490: Examining the Intersection of Immunology and Emotion - Dr. Fulvio D'Acquisto
25/02/2019 Duration: 41minDr. Fulvio D'Acquisto is Professor of Immunology and Director of the Health Science Research Centre at the University of Roehampton in London. Through his research, Fulvio seeks to understand how emotion and lifestyle influence our immune response. He is investigating how different types of emotions (both positive and negative) affect our immune systems at the level of individual cell types and cellular responses. Fulvio’s hypothesis is that each emotion has a particular signature effect on a person’s immune system. Fulvio is also fascinated by psychology, psychotherapy, archetypes, and personality types. He enjoys reading and attending presentations on these subjects when he’s not working in the lab. In addition, Fulvio likes drawing to relax and explore his own creative imagination process. Fulvio attended the University of Naples “Federico II” in Italy where he earned a Bachelor of Science degree in Pharmaceutical Chemistry, a Master of Research degree in Experimental Pharmacology, and a Ph.D. in Experimen
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489: Mathematician and Communicator with an Eye for Modeling Cataract Development in Populations Over Time - Dr. Talithia Williams
18/02/2019 Duration: 50minDr. Talithia Williams is an Associate Professor of Mathematics and Associate Dean for Research and Experiential Learning at Harvey Mudd College. In addition, Talithia is Host of the PBS Series NOVA Wonders and author of the book Power in Numbers: The Rebel Women of Mathematics. Talithia is a mathematician who does disease modeling. She has been working with the World Health Organization to create models of the rates at which groups of people develop cataracts over time. Left untreated, cataracts can cause partial or complete blindness. In the U.S., cataract surgery is quick and accessible, but this is not the case in other countries. Knowing where there is the greatest need for treatment is important for the World Health Organization as they make decisions on where to send ophthalmologists to perform surgeries. In addition to being a mathematician and researcher, Talithia is a mother of three boys, a wife of 15 years, a TV show host, an author, and a person of faith. She enjoys spending time with her family,
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488: Studying the Evolutionary Diversity of Squishy Sea Creatures - Dr. Joseph Ryan
11/02/2019 Duration: 37minDr. Joseph Ryan is an Assistant Professor of Biology at the Whitney Laboratory for Marine Bioscience at the University of Florida. In the lab, Joe studies DNA from squishy marine invertebrates like ctenophores (e.g. comb jellies), cnidarians (e.g. jellyfish), tunicates (e.g. sea squirts), and sea cucumbers. His goal is to understand how different types of animals are related, how animals adapt to extreme environments, and how animals have evolved the extraordinary diversity we see today. When he’s not at work, Joe loves spending time with his family. He and his two kids (one and three years old) enjoy dancing to “Tiny Bubbles” by Don Ho and songs by the band The Clash. Joe is also a fan of singer-songwriter Slim Whitman, and he plays guitar, drums, and keyboard. Joe received his PhD in bioinformatics from Boston University. Afterwards, he was awarded a research fellowship at the National Human Genome Research Institute at the National Institutes of Health and subsequently worked as a postdoctoral scholar at S
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487: Making Mathematical Models to Understand Immune System Responses to Cancer - Dr. Lisette DePillis
04/02/2019 Duration: 39minDr. Lisette DePillis is the Norman F. Sprague Jr. Professor of Life Sciences, Professor of Mathematics, and Chair of the Department of Mathematics at Harvey Mudd College. Lisette is an applied mathematician. She creates mathematical models or structures to help describe questions in biology. In particular, Lisette has been working on building models to improve our understanding of diseases related to the human immune system, such as cancer. Her goal is to understand the genesis and dynamics of diseases as well as to discover improved and personalized treatment approaches. In her free time, Lisette plays piano, sings, dances, and reads for fun. She also enjoys spending time playing family games, visiting new places, going to movies, trying new restaurants, and going for walks outside with her husband and three daughters. They live up against the foothills in California, so they don’t have to walk far to be immersed in nature and see lots of wildlife. She received her PhD in mathematics from the University of C
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486: Theoretical Physicist and Author Discovering Novel Forms of Matter and Improving our Understanding of the Universe - Dr. Paul Steinhardt
28/01/2019 Duration: 44minDr. Paul Steinhardt is the Albert Einstein Professor in Science, Professor in the Department of Physics, Professor in the Department of Astrophysical Sciences, and Director of the Princeton Center for Theoretical Sciences. In addition, Paul is author of the popular science book Endless Universe: Beyond the Big Bang and the recently released book The Second Kind of Impossible: The Extraordinary Quest for a New Form of Matter. Paul is a theoretical physicist whose areas of study range from the nature of particles to the origins of the universe. He uses the known laws of nature to unravel some of the many secrets of nature that remain. His goal is to understand why things are the way they are and to discover connections between seemingly unrelated phenomena. In his free time, Paul enjoys hanging out with his four kids and his grandchild. Lately, he has also become fond of attending opera performances and hiking. Paul received his B.S. in physics from the California Institute of Technology (Caltech) and his M.A.
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485: Studying How Disruptions in Circadian Control of Cell Division May Cause Cancer - Dr. Carla Finkielstein
21/01/2019 Duration: 40minDr. Carla Finkielstein is an Associate Professor of Biological Sciences within the Biocomplexity Institute of Virginia Tech. She is also Director of the Integrated Cellular Response Laboratory at Virginia Tech, a Member of the Executive Committee of the Susan G. Komen Blue Ridge Board, and past member of the Board of Directors of the Virginia Breast Cancer Foundation. In the lab, Carla is interested in understanding the mechanisms cells use to measure time to regulate cell division. Evidence supports that people with circadian disorders have a higher incidence of cancer. Carla hypothesizes that cancer may occur when the clocks within cells don’t function properly. In these cases, the clocks may signal to the cell to divide too frequently. Carla’s goal is to understand how this process occurs so that we can fix the issue, detect the problem early to provide treatment, or prevent it from happening. Carla’s favorite hobby is cooking. She loves making new and creative dishes that bring together different colors,
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484: Discovering Drugs for Targeted Treatment in Brain Damage and Disease - Todd Zankel
14/01/2019 Duration: 43minDr. Todd Zankel is co-founder and Chief Scientific Officer of Mercaptor Discoveries, Inc., a biotech company focused on developing molecules to treat brain injury and degeneration. Todd studies chemistry and molecular biology to develop new drugs to treat diseases of the central nervous system and brain. The molecules they are working on now help reduce side effects by making drugs only active in the parts of the body they are supposed to target. When he’s not working, Todd likes to read non-science books and take his dog for walks in the hills and woods near his house. Todd received his B.A. in Chemistry from Reed College and his Ph.D. in Chemistry from Columbia University. Afterwards, he accepted a position as an NIH postdoctoral fellow at the Plant Gene Expression Center in Berkeley, California as well as the Chemistry Department of ETH in Zurich, Switzerland. Todd then worked for BioMarin Pharmaceutical for about eight years. Before co-founding Mercaptor Discoveries, Todd co-founded Raptor Pharmaceuticals
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483: Developing Novel Treatments for Neurological Disease Using Neural Networks and Brain Stimulation - Dr. Michael Fox
07/01/2019 Duration: 44minDr. Michael Fox is an Associate Professor of Neurology at the Harvard University Medical School and Director of the Laboratory for Brain Network Imaging and Modulation. In addition, Mike is Associate Director of the Berenson-Allen Center for Noninvasive Brain Stimulation, Co-Director of the Beth Israel Deaconess Medical Center Deep Brain Stimulation Program, Assistant Neuroscientist at Massachusetts General Hospital, and a practicing clinical neurologist at the Beth Israel Deaconess Medical Center. In Mike’s research, he uses wiring diagrams of the human brain to try to make sense of brain problems and help patients. In the clinic, Mike treats patients with movement disorders like tremor and Parkinson’s disease using deep brain stimulation. He also uses noninvasive brain stimulation to treat people with psychiatric conditions like depression. When Mike isn’t doing research in his lab or working with patients in the clinic, he loves spending time with his wife and two daughters. They enjoy hiking and having fu
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482: Studying the Role of Sex and Gender in Health and Disease - Dr. Janine Austin Clayton
31/12/2018 Duration: 44minDr. Janine Austin Clayton is the Associate Director for Research on Women’s Health and Director of the Office of Research on Women’s Health at the National Institutes of Health. There are 27 Institutes and Centers at the National Institutes of Health (NIH). Research on women’s health is being conducted across all of these Institutes, and Janine helps lead and coordinate these efforts. In addition, she champions and celebrates the exceptional work that NIH-supported researchers around the world are doing. Janine’s own research focuses on issues in women’s health and diseases of the eye. Janine has a wide variety of interests outside of science, including visiting art museums near her home in Washington DC and around the world. She also likes spending her free time hanging out with her family, listening to jazz music, playing the piano, reading the Sunday paper, and staying active through yoga, Tai Chi, and Zumba. She was awarded her undergraduate degree with honors from Johns Hopkins University and her medical
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481: Researching the Regulation of Circadian Rhythms - Dr. Joseph Takahashi
24/12/2018 Duration: 38minDr. Joseph S. Takahashi is Professor and Chair of Neuroscience and the Loyd B. Sands Distinguished Chair in Neuroscience at the University of Texas Southwestern Medical Center. He is also an Investigator in the Howard Hughes Medical Institute. Joe and his lab members are trying to better understand the biological clocks in our bodies that control our 24-hour schedules. A special set of genes within nearly all of our cells turns on and off each day to regulate a wide variety of biological functions, and Joe is studying these genes and how they contribute to our biological rhythms. When Joe isn’t at work, he enjoys playing tennis, skiing, hiking, eating delicious food, and drinking great wine. Joe received his B.A. in biology from Swarthmore College and he was awarded his Ph.D. in neuroscience from the University of Oregon in Eugene. Afterwards, he conducted postdoctoral research as a pharmacology research associate at the National Institute of Mental Health. Before moving to UT Southwestern, Joe served on the
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480: Investigating Interactions Between Amphibian Immune Systems, Invading Pathogens, and the Environment - Dr. Barbara Katzenback
17/12/2018 Duration: 37minDr. Barbara Katzenback is an Assistant Professor in the Department of Biology at the University of Waterloo. Amphibian populations are declining worldwide, and one reason for their decline is their susceptibility to diseases that are emerging in their environments. Barb studies how frogs defend themselves from diseases to stay alive, and she also investigates how the environments that frogs live in impact their ability to defend against diseases. Barb’s hobbies outside of science include engaging in a variety of physical activities like running, yoga, and hiking with her husband and two dogs. She’s also experimented with soccer, spin classes, cross country skiing, rock climbing, and inner tube water polo. Some of her other interests include pottery, art, crafting, baking, gardening, sewing, and leisure reading. Barb earned her BSc with Honors in Immunology and Infection from the University of Alberta. She received her PhD in Physiology, Cell, and Developmental Biology from the University of Alberta as well. B
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479: Putting Patients First in Developing Drugs to Transform Radiation Therapy for Cancer - Dr. Robert A. Beardsley
10/12/2018 Duration: 48minDr. Robert A. Beardsley or "Al" is a Co-Founder and the Chief Operating Officer at Galera Therapeutics, a clinical-stage biotech company discovering and developing innovative cancer treatments. Al is interested in developing new drugs that target how oxygen is metabolized in cells. In particular, Al and the team at Galera Therapeutics are working to develop therapeutics to use with radiation therapy that will block the processes that cause damage to normal tissue while also increasing damage to the tumor. While Al is passionate about science and drug development, he also enjoys watching soccer, coaching soccer, being outdoors, and hiking in the mountains in his free time. Al received his BS in Chemical Engineering from the University of Iowa, an MBA in finance from the University of Chicago, and subsequently his PhD in Biochemical Engineering from the University of Iowa. Prior to co-founding Galera Therapeutics, Al served as CEO at Metabolic Solutions Development Corporation, CEO of Kereos, acting CEO at Meta
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478: Illuminating the Quantum Physics of Ultra-Cold Atoms - Dr. Chad Orzel
03/12/2018 Duration: 39minDr. Chad Orzel is the R. Gordon Gould Associate Professor of Physics at Union College. He is also author of the popular science books How to Teach Physics to Your Dog, How to Teach Relativity to Your Dog, Eureka: Discovering Your Inner Scientist, and the soon-to-be-released book Breakfast with Einstein: The Exotic Physics of Everyday Objects. In addition, Chad regularly contributes blog articles for Forbes Magazine. Chad studies ultracold atoms to improve our understanding of atomic physics. He uses lasers to drop the temperature of samples of atoms to just millionths or billionths of a degree above absolute zero. At these very cold temperatures, the atoms are moving very slowly, and interesting quantum effects arise. Free time can be hard to find with two kids and a puppy at home, but Chad enjoys hanging out with his family, reading science fiction and fantasy books, and playing basketball during his lunch hour at work. Chad received his B.A. in Physics from Williams College and his Ph.D. in Chemical Physics
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477: Researching Soft Robots, Medical Robots, and Haptics in Human-Robot Interactions - Dr. Allison Okamura
26/11/2018 Duration: 37minDr. Allison Okamura is a Professor of Mechanical Engineering at Stanford University. She also holds a courtesy appointment in Computer science there. Research in Allison’s lab examines three different areas of robotics. The first is haptics, which involves human machine interactions through the sense of touch. The second is designing medical robots that can, for example be used to help people recover from stroke or perform surgery. A final area that Allison studies is creating soft robots that can conform to their environments. Much of Allison’s free time is spent with her husband, daughter, and son. When she’s not at work, Allison also enjoys relaxing, running, and playing ice hockey. Allison received her B.S. in Mechanical Engineering from the University of California, Berkeley, and she was awarded her M.S. and Ph.D. both in Mechanical Engineering from Stanford University. Before joining the faculty at Stanford University, Allison was Professor and Vice Chair of Mechanical Engineering at Johns Hopkins Unive
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476: Developing Methods to Detect and Deter Use of Performance-Enhancing Substances in Sport - Dr. Mario Thevis
19/11/2018 Duration: 42minDr. Mario Thevis is Vice President of Research, Professor, and head of the Centre for Preventive Doping Research at the German Sport University of Cologne. He is also Director of the European Monitoring Center for Emerging Doping Agents (EuMoCEDA), a forensic chemist, Editor and Chief of the journal Drug Testing and Analysis, and a Research Scientist with the Partnership for Clean Competition. Mario’s time in the lab is split between research and performance of routine doping control work. On the research side, he is developing novel means and analytical methods to test athletes for the use of banned substances and methods of doping. Substances tested for include stimulants, steroids, blood doping, and others. The routine doping control side of Mario’s work involves testing samples for banned substances and investigating positive test cases. When he’s not working in the lab, Mario enjoys spending time with his family and watching soccer matches. He received his undergraduate education in organic chemistry fro
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475: Designing Drugs to Decrease Damage in Healthy Tissue During Radiation Therapy Cancer Treatments - Dr. Dennis Riley
12/11/2018 Duration: 37minDr. Dennis Riley is Co-Founder and Chief Scientific Officer at Galera Therapeutics, a clinical-stage biotech company discovering and developing innovative cancer treatments. He is also an Adjunct Professor of Chemistry at Washington University in St. Louis. Dennis and his colleagues have been developing synthetic enzymes that target undesired or toxic metabolic byproducts. One compound Dennis has developed protects healthy tissue from radiation damage during cancer treatment. When he’s not doing work, Dennis enjoys mountain biking, golfing, and amateur astronomy. He earned his Bachelor’s degree in chemistry and mathematics from Heidelberg College and his PhD in inorganic chemistry from The Ohio State University. Afterwards, Dennis conducted postdoctoral research at the University of Chicago. Dennis began his career working in research and development with Proctor and Gamble, and he spent much of his career working at Monsanto where he held the positions of Senior Science Fellow and Manager of Metal-Mediated C
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474: Developing Novel Nature-Inspired Drug Delivery Systems - Dr. Kathryn Whitehead
05/11/2018 Duration: 42minDr. Kathryn (Katie) Whitehead is an Assistant Professor in Chemical Engineering at Carnegie Mellon University where she also holds a courtesy appointment in Biomedical Engineering. Research in Katie’s lab group focuses on therapeutic drug delivery. Their goal is to make the process of drug delivery more efficient by sending medicine only to the specific parts of the body where they are needed. Katie is also working to create new precision medicines using RNA and DNA and to develop the drug delivery systems for these future medicines. Since she was a PhD student, Katie has been interested in gardening. She started with just a single tomato plant, and now she grows over 20 different varieties of heirloom tomatoes, as well as other vegetables, fruits, and berries. Katie received her bachelor’s degree in chemical engineering from the University of Delaware and her PhD in chemical engineering from the University of California, Santa Barbara. Afterwards, she conducted postdoctoral research in the Koch Institute for
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473: Investigating the Intersection of Public Health, Infectious Disease, and Behavior Change to Improve Human Health - Dr. Satesh Bidaisee
29/10/2018 Duration: 50minDr. Satesh Bidaisee is a Professor of Public Health and Preventative Medicine and Assistant Dean for Graduate Studies at St. George’s University in Grenada. He is also an Adjunct Professor in the Center for Global Health at Old Dominion University and a Visiting Professor at Chitkara University in India and at Kasetsart University in Thailand. Many aspects of human health are linked with conditions in our environment. Satesh’s research aims to identify and understand environmental factors that can impact human health, both positively and negatively. One of Satesh’s passions outside of science is aviation. He has been fascinated by aircraft since childhood, and for the past decade, Satesh has enjoyed flying throughout the Caribbean region as a private pilot. Satesh received his Doctor of Veterinary Medicine Degree (D.V.M.) from the University of the West Indies, St. Augustine Campus, a Master’s of Science (M.S.) degree in Public Health from St. George’s University, and a Doctor of Education Degree (Ed.D.) from