Future Science Group

Revealing the regulome: using multiomic approaches to explore epigenetics and DNA expression

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Synopsis

Explore the realm of epigenetics and gene expression, discovering the different omic ‘lenses’ used to examine these processes and the power of single-cell studies to reveal provide a comprehensive multiomic view of cells and their biology.   This episode features the ever-buoyant Will Greenleaf, Associate Professor of Genetics at Stanford University School of Medicine (CA, USA) and head of the Greenleaf Lab. Will takes us through his lab’s work, detailing his attempts to understand the compacting of DNA into cell nuclei and how this impacts gene expression and epigenetic regulation. Discover the emerging new research focus that Will has coined the “Regulome” – the collection of physical molecular components that control gene expression through factors such as chromatin accessibility. To explore these new frontiers Will often encounters questions with no technologies available to ask them. So what does he do? Invent the technologies he needs! Find out how his lab came to develop the, now widely u