Labanimal

The June episode of 3-Minute 3Rs from the North American 3Rs Collaborative (www.na3rsc.org), the NC3Rs (www.nc3rs.org.uk), and Lab Animal (www.nature.com/laban) Papers; 1. https://bit.ly/2UH4hZt 2. https://go.nature.com/2W5CIea 3. https://bit.ly/2Fi4td4 [LA] On the road to the clinic, immunocompromised mice transplanted with patient-derived xenografts have been a frequent step for testing a drug’s efficacy and safety. However, there may soon be fisher options afoot that might help replace some of those mice. Writing in the June issue of the journal Cell, David Langenau and colleagues describe an adult zebrafish xenograft model, into which they successfully engrafted several different solid pediatric tumors. Larval versions had existed before, but an adult model offers a few notable advantages. Bigger fish can bear a larger tumor burden for a longer period of time than the small fry. Adults can be orally gavaged, meaning researchers can know exactly how much of a drug they are getting. And with acclimatio