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Depression is a leading cause of ill health and disability, affecting over 280 million people worldwide. 3. Andrew Clegg, PhD, Professor of Health Services Research at the University of Central Lancashire in the UK, led a review of 73 randomized controlled trials including nearly 5,000 adults with depression. The research suggests that light to moderate exercise, such as walking and cycling, can reduce depression symptoms just as effectively as antidepressant medications and psychological therapy.