Manifold

Steve answers questions about recent progress in AI/ML prediction of complex traits from DNA and applications in embryo selection.Highlights:Overview of recent advances in trait predictionWould cost savings from breast cancer early detection pay for genotyping of all women?How does IVF work? Economics of embryo selectionWhole embryo genotyping increases IVF success rates (pregnancy per transfer) significantlyFuture predictionsSome relevant scientific papers:Preimplantation Genetic Testing for Aneuploidy: New Methods and Higher Pregnancy Rates - https://infoproc.blogspot.com/2022/01/preimplantation-genetic-testing-for.html2021 review article on complex trait prediction - https://arxiv.org/abs/2101.05870Accurate Genomic Prediction of Human Height - https://www.genetics.org/content/210/2/477Genomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer - https://www.nature.com/articles/s41598-019-51258-xGenetic architecture of complex traits and disease risk predictor