Bbc Inside Science

Vaccination has eradicated smallpox, a disease that decimated populations through the 20th century. Polio is almost gone too, and measles is no longer the pervasive childhood threat it once was. It’s clear that vaccination is our best tool to halt the threat of SARS CoV 2, and allow the return to a less restricted way of life. But it takes time to develop and test vaccines although the technologies used to create them have moved on significantly over the last few decades.Professor Jonathan Ball, a virologist at Nottingham University, talks Adam Rutherford through the several types of vaccine that are being explored in the effort to stop the coronavirus pandemic, and how they work. These include live attenuated virus vaccines that are genetically modified to appear to be SARS CoV 2 to the immune system, and RNA subunit vaccines that trick the body into recognising the virus. He discusses the way different vaccines work against disease, and how they trigger different types of immune response. Before a vaccine

Skulls give researchers a great deal of insight into how an animal might have evolved, and skulls can be sensibly compared between species and groups of animals. The 10,000 species of bird around the world are what’s left of an even more diverse group, the dinosaurs. But research on their skulls has revealed that despite the birds’ exceptional diversity, they evolve far more slowly than their dinosaur relatives ever did. This is one of the findings of a huge skull mapping project at the Natural History Museum led by Anjali Goswami. Marnie Chesterton delights Adam Rutherford with what she has recently learned about the single-celled fungus that is yeast. She recently visited the National Collection of Yeast Cultures in Norwich, which stores hundreds of thousands of strains of yeast. She discovered that yeast is not only responsible for the production and subtle flavours of bread, yeast and chocolate, but also that some species of yeast can actually clean carbon dioxide from the air and can be used to feed liv

Over the next couple of weeks almost all children in the UK will be back to school. But the pandemic hasn’t ended, and we are far from having a complete understanding of how this virus works, including how it is transmitted and how it affects younger people. Pretty much everyone is in agreement that kids need to be back at school, as the costs of not being physically in classrooms are great - for the education of kids, for their mental health, and for the finances of parents needing to work. But what does the science say about the risks for schools reopening? Will we see a rise in infections in younger people, and hot-spots for the wider community? Adam Rutherford discusses these issues with Paul Hunter, Professor of Medicine at Norwich Medical School, and he finds out from Professor Tim Spector if his Kings College COVID symptom tracker app can shed any more light on whether children display the same COVID symptoms as adults, or could we be missing infections in the young?Marnie Chesterton eavesdrops on an

Red clay bricks are among the most ubiquitous building materials worldwide. Julio D'Arcy, a chemist at Washington University in St. Louis, Missouri, describes to Adam Rutherford how he and his team have turned ordinary house bricks into energy storage units that can power home electronic devices – thanks to the red iron oxide (rust) pigment and a conductive plastic nano-material infused into the bricks These new ‘smart bricks’ can be charged to hold electricity a bit like a battery.As the pandemic continues, we continue to try to find ways to manage it, treat the disease, detect it and cure it. As necessity is the mother of invention, we're currently witnessing some of the most intense periods of scientific innovation in the 21st century. And there have been some incredible discoveries, innovations and inventions in just the last 6 months. The Royal Academy of Engineering announced a special round of awards this week, to recognise the heroics of engineers, designers and scientists to help tackle this pandem

COVID19 is a chilling reminder of how pathogens from animals can jump into humans. But it’s not the first time. SARS, Ebola, West Nile virus and bubonic plague are all serious infectious diseases that sat in a host species before crossing to us. But what causes this to happen? Individual case studies suggest that we are partly to blame in the way we use the land, either through urbanisation or agriculture. But how widespread is this, and do our global patterns of land use systematically put us at risk? Adam talks to environmental biologist David Redding from the Zoological Society of London, and his team, whose new study suggests they do.Jessica Bradford, the Keeper of Collection Engagement at the Science Museum, asks for your help with another mystery object that they’ve uncovered during their recent collection move. Roland Pease reports on the chain of interconnected faults which has stimulated Los Angeles' preparation for “the big one”, after southern California was hit by one of the biggest earthquake

Adam reveals new research which overturns received wisdom about how sperm swim. More than three centuries after Antonie van Leeuwenhoek peered down his early microscope to observe human sperm or ‘animalcules’ swimming with a ‘snakelike movement, like eels in water’, high-tech observations now reveal that this was, in fact, an optical illusion.Hermes Gadelha from Bristol University used 3D microscopy, a high-speed camera and mathematics, to reconstruct the true movement of the sperm tail. Much to his amazement, sperm have a highly sophisticated way of rolling as they swim. They do this to counter the numerous irregularities in their morphology which would otherwise send them swimming in circles. In doing so, they are able to propel themselves forwards. This highly complex set of movements, seen in 3D, is obscured in 2D when sperm appear to use a symmetrical eel-like motion to swim.Also on the programme, Adam gets an update from Mark Miodownik on the Big Compost Experiment, the citizen science project that

The Science Museum Group looks after over 7.3 million items. As with most museums, the objects you see on display when you visit are only the tip of the iceberg of the entire collection. Up until now, many of the remaining 300,000 objects have been stored in Blythe House in London. But now the collection is being moved to a purpose-built warehouse in Wiltshire. The move is a perfect opportunity for curators to see what’s there, re-catalogue long hidden gems and to conserve and care for their treasures. But during the process they have discovered a number of unidentified items that have been mislabelled or not catalogued properly in the past and some of them are just so mysterious, or esoteric, that the Science Museum needs the aid of the public to help identify them, and their uses. We’ll be showcasing items over the next weeks and months, but this week, Jessica Bradford, the keeper of collection engagement at the Science Museum is asking Inside Science listeners if they recognise, or can shed light on the po

A pre-print is a way for scientists to get their work out quickly for other scientists to comment on and debate. But pre-prints are not peer reviewed; they have not undergone the scrutiny of reviewers and journal editors. They're generally seen as a good thing, but are just a step on the way for science to be verified and published. But it's important to note that the science can be wrong or sloppy in pre-prints, so they have never really been part of the process by which science is disseminated to the general public. That is, until the COVID pandemic. The speed at which the science can be shared has led to pre-prints becoming more and more scrutinised by journalists and used to inform the public about this terrible disease. Fiona Fox, CEO of the Science Media Centre, which is an independent press office for the scientific community, discusses the potential pitfalls of using pre-prints with Adam Rutherford and with Dr Jonathan Read from Lancaster University, who himself got caught up in a pre-print firestorm

Science is all about self-reflection. Scientists constantly check themselves, share their work, and check each other’s data. But how robust is the science upon which civilisation is built, the science which has mapped genomes, cured diseases, split atoms and sent people to the moon? Adam talks to Stuart Ritchie, a psychologist from Kings College London, about his new book Science Fictions which explores everything from biases and human fallibility, to outright fraud. He also talks to microbiologist turned image sleuth, Elisabeth Bik, whose work is revealing that manipulated images appear in scientific papers shockingly often.Now we are several months into the COVID pandemic, scientists are beginning to share their first insights into whether people retain immunity to SARS-CoV-2 after they've had the disease COVID-19. At Kings College London, Senior Lecturer in Infectious Diseases, Katie Doores and her team tracked the antibody levels over the first months after infection with COVID-19. Their first preprint f

Is the UK losing its way when it comes to satellite navigation? There's GPS from the US, but other countries and regions, including Russia, China, India and Japan, either have, or are building, satellite navigation systems of their own. The EU has Galileo, but with Brexit, Britain is no longer involved. The Government has announced that it’s just acquired a satellite technology company called OneWeb. It’s primary role is enhanced broadband, but there’s talk of adding in a navigation function to the constellation of satellites. But how feasible will that be? In an era of cyber-crime, misinformation, disinformation, state-sponsored attacks on rival countries’ infrastructure, government-imposed internet shutdowns in places like Eritrea and Kashmir, the World Wide Web is an increasingly dark and troubled place. Making sense of how the internet has changed from the democratic, sharing, open platform it was designed to be, and predicting what’s next, are the web scientists. Professor Dame Wendy Hall, Regius Profess

As we’re beginning to understand more about SARS-CoV-2, the virus that causes COVID-19, we’re hopefully starting to get some clues on how to deal with the next viral pandemics, and even look at ways of stopping them from happening. To do this, we have to go back to where the virus jumped from its animal host into humans. Like this current coronavirus, many of the pandemic viruses (SARS, MERS HIV, Ebola…to name a few) are zoonotic diseases. They start in wild animals and evolve to jump to humans (sometimes via another animal species). It’s not the animal’s fault. It’s evolution. But has our tangled, often exploitative relationship with wild animals made it harder to stop future pandemics? A paper just published asks these questions and tries to figure out how to prevent future zoonotic epidemics. Dr. Silviu Petrovan (Researcher in the Department of Zoology in Cambridge) and Associate Professor Alice Hughes (Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences) highlight some of the 161 possib

Adam Rutherford is back to celebrate the 20th anniversary of one of the most ambitious and revolutionary scientific endeavours of all time - the Human Genome Project. Its scope and scale was breath-taking, set up to read every one of the 3 billion nucleotides, or letters of genetic information, contained within the DNA in every cell of the human body. It took seven years, hundreds of scientists, cost almost $3 billion and, amazingly, came in under budget and on time. Adam reflects back on that momentous time with Ewan Birney, Director of the European Bio-informatics Institute, part of the European Molecular Biology Laboratory. Twenty years ago, he was a PhD student working on the project, in the months leading up to the first draft. The Human Genome Project underpins many branches of science, from human evolution and synthetic biology to forensic genetics and ancestry testing. But a key motivation for the project was to alleviate human suffering. While the ‘cures’, hyped by the media back in 2000,

Throughout the pandemic, we've seen an explosion in information about the science of the virus, SARS-CoV-2, and the disease it causes, COVID-19. An article online, or a text forwarded, could be true and sounds about right, but how do you know that it's accurate? When scrolling through your social feed, how do you decipher fact from fiction? A new report, by Kings College London and Ipsos MORI, reveals that those of us who get our news from social media are more likely to believe misinformation about the pandemic.Marnie talks to Jack Goodman of the Anti-Disinformation Unit at BBC Online, a new team set up to tackle the problem. She finds out how science fact turns to science fiction online, and what the team is doing to try to counter this.Now that wearing face masks are now mandatory in a number of situations, a lot of us are making our own. BBC Inside Science listeners sent in lots of ideas about the design, maintenance and durability of face masks, and other ways to protect against spreading the coronavi

As the UK gradually begins to ease out of lockdown, Marnie explores how engineers are hoping to reduce the spread of Covid-19. We’ve learned how infected people exhale droplets and aerosols, containing the virus, and how we can then either inhale them, or transfer them to our faces by touching contaminated surfaces. Many shops already have screens and physical barriers, while schools and offices are re-configuring desks and walkways. What role does the environment play in our overall risk of becoming infected and what can we do about it? This is the focus of the SAGE Environmental Working Group. Marnie talks to its Chair, Catherine Noakes, Professor of Environmental Engineering for Buildings at Leeds University. Minimising the risks that contaminated surfaces pose is a key challenge that engineers are now trying to address. Marnie asks Birmingham University Research Scientist, Felicity de Cogan, about the surface she created which kills bacteria in seconds. She's now re-purposing the technology to kill t

As the lockdown eases and some children, in preschool and primary years, start heading back to school, what impact will this have on the pandemic, how will we know and is there anything we can do about it? Marnie Chesterton talks to Professor of Mathematical Biology at Cambridge University, Julia Gog, who co-chaired the group that advised the government on the impact of easing school closures. She explains why the limited opening of schools provides a golden opportunity to learn about its impact on the pandemic, and inform what happens in September when the new school year begins. Marnie also talks to Tim Spector, Professor of Genetic Epidemiology at King’s College London, to find out what parents can do to help control the spread of the virus in their communities. He runs the COVID Symptom Study, a huge citizen science project that’s pinpointing the symptoms most closely associated with Covid-19. Millions of British adults have downloaded the app, to take part in the study, logging how they feel each day a

Inside Science this week is all about our information - the stuff we volunteer and the traces our everyday movements leave behind.With the launch of NHS Test and Trace across England, if you start to feel unwell with suspected Covid-19 and call a new NHS hotline 119, you’ll be tested for the virus. Your close contacts will be traced and, if you test positive, you'll be asked to self-isolate for 7 days, and your contacts asked to quarantine for 14 days. The route to those close contacts is currently through manual tracing - you have to give the details of everyone with whom you’ve been in close contact. But in the coming weeks, the plan is to integrate the NHSX app, currently being trialled on the Isle of Wight. This will pick up close contacts with people you don't know, on public transport, for example, provided they also have the app. It’s a new way to fight a pandemic, but the pioneers here are the residents of the English town of Haslemere in Surrey who, back in 2017, were tackling a terrifyingly contag

In response to listeners who have expressed coronavirus fatigue in recent weeks, Marnie Chesterton brings us up to date on some of the best and brightest breaking science we might have missed, with BBC’s Non-Covid-19 Science Correspondent Jonathan Amos.Inching back to pandemic news, Marnie investigates the fallout of the lockdown from a climate perspective. In many countries, citizens have been asked to stay at home and not to travel unless it’s strictly necessary. As a result, the hubbub of normal life has slowed to a trickle. What impact has this had on levels of carbon dioxide in the atmosphere? Corinne Le Quéré, the Royal Society Professor of Climate Change Science at the University of East Anglia, explains just how dramatically these emissions have been affected around the world. And the chances that intelligent life exists on other planets. David Kipping, Assistant Professor of Astronomy at Columbia University in the US, has calculated the odds of both life and intelligent life existing if he were to

R seems to have found its way into the newspapers and on Radio 4 as if it’s a word, or a letter, that we should all be familiar with and understand. As part of the government’s briefing on Sunday, it appeared in a pseudo-equation, the infographic - 'COVID alert level = R + number of infections' - the Government called R the 'Rate of Infection', but it is commonly known as the 'Reproduction Number'. So what exactly is R, and what does it do? Mathematical Biologist, Kit Yates, from the University of Bath, clears up the confusion, and explains how R was first calculated for covid-19. And one of the scientists tracking R in the UK is Petra Klepac, who is Assistant Professor in Infectious Disease Modelling at the London School of Hygiene and Tropical Medicine. She explains how crucial R is in tracking the pandemic and how it’s now being used to shape the way we get out of lockdown.There are so many variables about who will survive Covid-19 and who, unfortunately, will not. Many people will only experience mild sym

Advice about whether the public should wear face masks, to protect against infection by the coronavirus, differs around the world. In Europe, policy recommendations are mostly geared towards homemade masks. As this country waits to find out how we’ll venture out of lock down, should we be wearing face masks out in public too? The government’s mantra throughout the pandemic has been “follow the science” but on this issue there is ongoing debate, with strongly held and differing views. The Royal Society’s DELVE Initiative (Data Evaluation and Learning for Viral Epidemics) put out a report this week to try to bring some clarity to the issue. Marnie Chesterton asks Professor of Primary Care Health Sciences at Oxford University, Trisha Greenhalgh, and microbiologist and Professor of Environmental Healthcare at the University of Southampton, William Keevil, why there is so little science to inform the policy-makers. If the government recommends that we all wear cloth masks, we'll be wearing them for the common goo

This week, the Government’s target to be testing 100,000 a day for COVID-19 looks like it won’t be met. But we’ve heard about many people who experienced the virus mildly, or who’ve tested positive with no symptoms at all. If you really want to know who has had the virus, the only way to tell for certain is with an antibody, or serology, test. Describing how they work is Professor of Virology at Nottingham University, Jonathan Ball. Eleanor Riley, Professor of Immunology and Infectious Disease at Edinburgh University, explains why its so important to get the specificity and sensitivity of these tests right, and reveals what they can and can't tell us about individual and population-wide exposure to the virus. We like citizen science on BBC Inside Science, it’s an opportunity for anyone and everyone to try their hand at some scientific projects, learn about the scientific process and help researchers crunch through masses of data. Professor Chris Lintott co-founded Zooniverse, the biggest citizen science platf