Synopsis
Periodic audiocasts from Science Signaling, the signal transduction knowledge environment.
Episodes
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The twins climbing Mount Everest for science, and the fractal nature of human bone
03/05/2018 Duration: 26minTo study the biological differences brought on by space travel, NASA sent one twin into space and kept another on Earth in 2015. Now, researchers from that project are trying to replicate that work planet-side to see whether the differences in gene expression were due to extreme stress or were specific to being in space. Sarah Crespi talks with Online News Editor Catherine Matacic about a “control” study using what might be a comparably stressful experience here on Earth: climbing Mount Everest. Catherine also shares a recent study that confirmed what one reddit user posted 5 years ago: A single path stretching from southern Pakistan to northeastern Russia will take you on the longest straight-line journey on Earth, via the ocean. Finally, Sarah talks with Roland Kröger of the University of York in the United Kingdom about his group’s study published this week in Science. Using a combination of techniques usually reserved for materials science, the group explored the nanoscale arrangement of mineral in bone
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Deciphering talking drums, and squeezing more juice out of solar panels
26/04/2018 Duration: 30minResearchers have found new clues to how the “talking drums” of one Amazonian tribe convey their messages. Sarah Crespi talks with Online News Editor Catherine Matacic about the role of tone and rhythm in this form of communication. Getting poked with a needle will probably get you moving. Apparently, it also gets charges moving in certain semiconductive materials. Sarah interviews Marin Alexe of The University of Warwick in Coventry, U.K., about this newfound flexo-photovoltaic effect. Alexe’s group found that prodding or denting certain semiconductors with tiny needles causes them to suddenly produce current in response to light. That discovery could enhance the efficiency of current of solar cell technologies. Finally, in our books segment, Jen Golbeck interviews Lucy Cooke about her new book The Truth About Animals: Stoned Sloths, Lovelorn Hippos, and Other Tales from the Wild Side of Wildlife. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Adam Levine/Flickr; Music: Je
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Drug use in the ancient world, and what will happen to plants as carbon dioxide levels increase
19/04/2018 Duration: 24minArmed with new data, archaeologists are revealing that mind-altering drugs were present at the dawn of the first complex societies some 5000 years ago in the ancient Middle East. Contributing writer Andrew Lawler joins Sarah Crespi to discuss the evidence for these drugs and how they might have impacted early societies and beliefs. Sarah also interviews Sarah Hobbie of the University of Minnesota about the fate of plants under climate change. Will all that extra carbon dioxide in the air be good for certain types of flora? A 20-year long study published this week in Science suggests theoretical predictions have been off the mark. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Public domain Music: Jeffrey Cook]
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How DNA is revealing Latin America’s lost histories, and how to make a molecule from just two atoms
12/04/2018 Duration: 22minGeneticists and anthropologists studying historical records and modern-day genomes are finding traces of previously unknown migrants to Latin America in the 16th and 17th centuries, when Asians, Africans, and Europeans first met indigenous Latin Americans. Sarah Crespi talks with contributing correspondent Lizzie Wade about what she learned on the topic at the American Association of Physical Anthropologists’s annual meeting in Austin. Sarah also interviews Kang-Keun Ni about her research using optical tweezers to bring two atoms—one cesium and one sodium—together into a single molecule. Such precise control of molecule formation is allowing new observations of these basic processes and is opening the door to creating new molecules for quantum computing. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Juan Fernando Ibarra; Music: Jeffrey Cook]
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Legendary Viking crystals, and how to put an octopus to sleep
05/04/2018 Duration: 21minA millennium ago, Viking navigators may have used crystals known as “sunstones” to navigate between Norway and Greenland. Sarah Crespi talks with Online News Editor David Grimm about how one might use a crystal to figure out where they are. Sarah also interviews freelancer Danna Staaf about her piece on sedating cephalopods. Until recently, researchers working with octopuses and squids faced the dilemma of not knowing whether the animals were truly sedated or whether only their ability to respond had been suppressed. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Nicholas Roerich, Guests from Overseas; Music: Jeffrey Cook]
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Chimpanzee retirement gains momentum, and x-ray ‘ghost images’ could cut radiation doses
29/03/2018 Duration: 30minTwo of the world’s most famous research chimpanzees have finally retired. Hercules and Leo arrived at a chimp sanctuary in Georgia last week. Sarah Crespi checks in with Online News Editor David Grimm on the increasing momentum for research chimp retirement since the primates were labeled endangered species in 2015. Sarah also interviews freelancer Sophia Chen about her piece on x-ray ghost imaging—a technique that may lead to safer medical imaging done with cheap, single-pixel cameras. David Malakoff joins Sarah to talk about the big boost in U.S. science funding signed into law over the weekend. Finally, Jen Golbeck interviews author Stephanie Elizabeth Mohr on her book First in Fly: Drosophila Research and Biological Discovery for our monthly books segment. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Crystal Alba/Project Chimps; Music: Jeffrey Cook]
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A possible cause for severe morning sickness, and linking mouse moms’ caretaking to brain changes in baby mice
22/03/2018 Duration: 21minResearchers are converging on which genes are linked to morning sickness—the nausea and vomiting associated with pregnancy—and the more severe form: hyperemesis gravidarum (HG). And once we know what those genes are—can we help pregnant women feel better? News intern Roni Dengler joins Sarah Crespi to talk about a new study that suggests a protein already flagged for its role in cancer-related nausea may also be behind HG. In a second segment, Tracy Bedrosian of the Neurotechnology Innovations Translator talks about how the amount of time spent being licked by mom might be linked to changes in the genetic code of hippocampal neurons in mice pups. Could these types of genomic changes be a new type of plasticity in the brain? This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Jacob Bøtter/Flickr; Music: Jeffrey Cook]
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How humans survived an ancient volcanic winter and how disgust shapes ecosystems
15/03/2018 Duration: 21minWhen Indonesia’s Mount Toba blew its top some 74,000 years ago, an apocalyptic scenario ensued: Tons of ash and debris entered the atmosphere, coating the planet in ash for 2 weeks straight and sending global temperatures plummeting. Despite the worldwide destruction, humans survived. Sarah Crespi talks with Online News Editor Catherine Matacic about how life after Toba was even possible—were humans decimated, or did they rally in the face of a suddenly extra hostile planet? Next, Julia Buck of the University of California, Santa Barbara, joins Sarah to discuss her Science commentary piece on landscapes of disgust. You may have heard of a landscape of fear—how a predator can influence an ecosystem not just by eating its prey, but also by introducing fear into the system, changing the behavior of many organisms. Buck and colleagues write about how disgust can operate in a similar way: Animals protect themselves from parasites and infection by avoiding disgusting things such as dead animals of the same species
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Animals that don’t need people to be domesticated; the astonishing spread of false news; and links between gender, sexual orientation, and speech
08/03/2018 Duration: 41minDid people domesticate animals? Or did they domesticate themselves? Online News Editor David Grimm talks with Sarah Crespi about a recent study that looked at self-domesticating mice. If they could go it alone, could cats or dogs have done the same in the distant past? Next, Sinan Aral of the Massachusetts Institute of Technology in Cambridge joins Sarah to discuss his work on true and false rumor cascades across all of Twitter, since its inception. He finds that false news travels further, deeper, and faster than true news, regardless of the source of the tweet, the kind of news it was, or whether bots were involved. In a bonus segment recording during a live podcasting event at the AAAS Annual Meeting in Austin, Sarah first speaks with Ben Munson of the University of Minnesota in Minneapolis about markers of gender and sexual orientation in spoken language and then Adrienne Hancock of The George Washington University in Washington, D.C., talks about using what we know about gender and communication to hel
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A new dark matter signal from the early universe, massive family trees, and how we might respond to alien contact
01/03/2018 Duration: 35minFor some time after the big bang there were no stars. Researchers are now looking at cosmic dawn—the time when stars first popped into being—and are seeing hints of dark matter’s influence on supercold hydrogen clouds. News Writer Adrian Cho talks with Sarah Crespi about how this observation was made and what it means for our understanding of dark matter. Sarah also interviews Joanna Kaplanis of the Wellcome Sanger Institute in Hinxton, U.K., about constructing enormous family trees based on an online social genealogy platform. What can we learn from the biggest family tree ever built—with 13 million members spanning 11 generations? In a bonus segment recording during a live podcasting event at the AAAS Annual Meeting in Austin, Sarah talks with Michael Varnum of Arizona State University in Tempe about what people think they will do if humanity comes into contact with aliens that just happen to be microbes. Live recordings sessions at the AAAS meeting were supported by funds from the European Commission. T
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Neandertals that made art, live news from the AAAS Annual Meeting, and the emotional experience of being a scientist
22/02/2018 Duration: 25minWe talk about the techniques of painting sleuths, how to combat alternative facts or “fake news,” and using audio signposts to keep birds from flying into buildings. For this segment, David Grimm—online news editor for Science—talks with host Sarah Crespi as part of a live podcast event from the AAAS Annual Meeting in Austin. Sarah also interviews Science News Editor Tim Appenzeller about Neandertal art. The unexpected age of some European cave paintings is causing experts to rethink the mental capabilities of our extinct cousins. For the monthly books segment, Jen Golbeck interviews with William Glassley about his book, A Wilder Time: Notes from a Geologist at the Edge of the Greenland Ice. Listen to previous podcasts. [Image: Marcus Trienke/Flickr; Music: Jeffrey Cook]
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Genes that turn off after death, and debunking the sugar conspiracy
15/02/2018 Duration: 14minSome of our genes come alive after we die. David Grimm—online news editor for Science—talks with Sarah Crespi about which genes are active after death and what we can learn about time of death by looking at patterns of postmortem gene expression. Sarah also interviews David Merritt Johns of Columbia University about the so-called sugar conspiracy. Historical evidence suggests, despite recent media reports, it is unlikely that “big sugar” influenced U.S. nutrition policy and led to the low-fat diet fad of the ’80s and ’90s. Listen to previous podcasts. [Image: Lauri Andler (Phantom); Music: Jeffrey Cook]
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Happy lab animals may make better research subjects, and understanding the chemistry of the indoor environment
08/02/2018 Duration: 22minWould happy lab animals—rats, mice, even zebrafish—make for better experiments? David Grimm—online news editor for Science—talks with Sarah Crespi about the potential of treating lab animals more like us and making them more useful for science at the same time. Sarah also interviews Jon Abbatt of the University of Toronto in Canada about indoor chemistry. What is going on in the air inside buildings—how different is it from the outside? Researchers are bringing together the tools of outdoor chemistry and building sciences to understand what is happening in the air and on surfaces inside—where some of us spend 90% of our time. Listen to previous podcasts. [Image: Austin Thomason/Michigan Photography; Music: Jeffrey Cook]
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Following 1000 people for decades to learn about the interplay of health, environment, and temperament, and investigating why naked mole rats don’t seem to age
01/02/2018 Duration: 19minDavid Grimm—online news editor for Science—talks with Sarah Crespi about the chance a naked mole rat could die at any one moment. Surprisingly, the probability a naked mole rat will die does not go up as it gets older. Researchers are looking at the biology of these fascinating animals for clues to their seeming lack of aging. Sarah also interviews freelancer Douglas Starr about his feature story on the Dunedin Multidisciplinary Health and Development Study—a comprehensive study of the lives of all the babies born in 1 year in a New Zealand hospital. Starr talks about the many insights that have come out of this work—including new understandings of criminality, drug addiction, and mental illness—and the research to be done in the future as the 1000-person cohort begins to enter its fifth decade. Listen to previous podcasts. [Image: Tim Evanson/Flickr/CC BY-SA 2.0; Music: Jeffrey Cook]
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The dangers of dismantling a geoengineered sun shield and the importance of genes we don’t inherit
25/01/2018 Duration: 23minCatherine Matacic—online news editor for Science—talks with Sarah Crespi about how geoengineering could reduce the harshest impacts of climate change, but make them even worse if it were ever turned off. Sarah also interviews Augustine Kong of the Big Data Institute at the University of Oxford in the United Kingdom about his Science paper on the role of noninherited “nurturing genes.” For example, educational attainment has a genetic component that may or may not be inherited. But having a parent with a predisposition for attainment still influences the child—even if those genes aren’t passed down. This shift to thinking about other people (and their genes) as the environment we live in complicates the age-old debate on nature versus nurture. Listen to previous podcasts. [Image: Collection of Dr. Pablo Clemente-Colon, Chief Scientist National Ice Center; Music: Jeffrey Cook]
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Unearthed letters reveal changes in Fields Medal awards, and predicting crime with computers is no easy feat
18/01/2018 Duration: 25minFreelance science writer Michael Price talks with Sarah Crespi about recently revealed deliberations for a coveted mathematics prize: the Fields Medal. Unearthed letters suggest early award committees favored promise and youth over star power. Sarah also interviews Julia Dressel about her Science Advances paper on predicting recidivism—the likelihood that a criminal defendant will commit another crime. It turns out computers aren’t better than people at these types of predictions, in fact—both are correct only about 65% of the time. Jen Golbeck interviews Paul Shapiro about his book, Clean Meat: How Growing Meat Without Animals Will Revolutionize Dinner and the World, in our monthly books segment. Listen to previous podcasts. [Image: Greg Chiasson/Flickr; Music: Jeffrey Cook]
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Salad-eating sharks, and what happens after quantum computing achieves quantum supremacy
11/01/2018 Duration: 19minDavid Grimm—online news editor for Science—talks with Sarah Crespi about two underwater finds: the first sharks shown to survive off of seagrass and what fossilized barnacles reveal about ancient whale migrations. Sarah also interviews Staff Writer Adrian Cho about what happens after quantum computing achieves quantum supremacy—the threshold where a quantum computer’s abilities outstrip nonquantum machines. Just how useful will these machines be and what kinds of scientific problems might they tackle? Listen to previous podcasts. [Image: Aleria Jensen, NOAA/NMFS/AKFSC; Music: Jeffrey Cook]
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Who visits raccoon latrines, and boosting cancer therapy with gut microbes
04/01/2018 Duration: 18minDavid Grimm—online news editor for Science—talks with Sarah Crespi about a long-term project monitoring raccoon latrines in California. What influence do these wild bathrooms have on the ecosystem? Sarah also interviews Christian Jobin of the University of Florida in Gainesville about his Perspective on three papers linking the success of cancer immunotherapy with microbes in the gut—it turns out which bacteria live in a cancer patient’s intestines can predict their response to this cutting-edge cancer treatment. Read the related papers: Routy et al., Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors, Science 2018 Gopalakrishnan et al., Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients, Science 2018 Matson et al., The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients, Science 2018 aan4236 Listen to previous podcasts. [Image: cuatrok77/Flickr; Music: Jeffrey Cook]
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Science’s Breakthrough of the Year, our best online news, and science books for your shopping list
21/12/2017 Duration: 32minDave Grimm—online news editor for Science—talks with Sarah Crespi about a few of this year’s top stories from our online news site, like ones on a major error in the monarch butterfly biological record and using massive balloons to build tunnels, and why they were chosen. Hint: It’s not just the stats. Sarah also interviews Staff Writer Adrian Cho about the 2017 Breakthrough of the Year. Adrian talks about why Science gave the nod to the Laser Interferometer Gravitational-Wave Observatory team for a second year in a row—for the detection of a pair of merging neutron stars. Jen Golbeck is also back for the last book review segment of the year. She talks with Sarah about her first year on the show, her favorite books, what we should have covered, and some suggestions for books as gifts. Listen to previous podcasts. [Image: f99aq8ove/Flickr; Music: Jeffrey Cook]
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Putting the breaks on driverless cars, and dolphins that can muffle their ears
14/12/2017 Duration: 21minWhales and dolphins have incredibly sensitive hearing and are known to be harmed by loud underwater noises. David Grimm talks with Sarah Crespi about new research on captive cetaceans suggesting that some species can naturally muffle such sounds—perhaps opening a way to protect these marine mammals in the wild. Sarah also interviews Staff Writer Jeffrey Mervis about his story on the future of autonomous cars. Will they really reduce traffic and make our lives easier? What does the science say? Listen to previous podcasts. [Image: Laura Wolf/Flickr; Music: Jeffrey Cook]