This Week In Microbiology

Vincent, Elio and Michael reveal the ASM COVID-19 summit, and how Salmonella injects a protein into the cell to drive suppression of the immune response. ASM COVID-19 Summit Value of SARS-CoV-2 diagnostic testing (mBio) How SARS-CoV-2 is changing (nextstrain) Contribute to COVID-19 data Salmonella effector suppresses inflammation (Cell Host Micr) Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Become a patron of TWiM.

Vincent, Elio and Michael discuss the stability of human coronaviruses on surfaces and in aerosols, and peptidoglycan production by a mosaic consisting of a bacterium within a bacterium within an insect. Links for this episode: Human coronavirus 229E infectivity on common surfaces (mBio) Aerosol and surface stability of SARS-CoV-2 (medRxiv) Peptidoglycan synthesis by a insect-bacteria mosaic (Cell) Letters read on TWiM 213 Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv  

The TWiM team reviews the coronavirus outbreak that began in Wuhan, China, and the finding that an IRF deficiency underlies Whipple’s disease.  2019-nCoV case tracking (JHU) Clinical features of infection with 2019-nCoV (Lancet) Early transmission dynamics of 2019-nCoV (NEJM) Isolation of 2019-nCoV (NEJM) TLR4 defect in Whipple’s disease (eLife) Become a Patron of TWiM! Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv

The Fellowship of the TWiM reveal that colorectal cancer-associated microbiota are associated with higher numbers of methylated genes in colonic mucosa, and identification of metabolites needed by the fire blight disease bacterium for virulence in apples. Become a patron of TWiM. Links for this episode: Colorectal cancer and the gut microbiome (PNAS) Fire blight (YouTube) Fire blight spreads north (NY Times) E. amylovora auxotrophs (Appl Environ Micro) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv

The Microbial Comrades present the oldest osteosynthesis in history, and how a small molecule produced by stressed bacteria is a warning signal that repels healthy populations to promote their survival. Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Become a patron of TWiM. Links for this episode P. aeruginosa PQS repels bacteria(J Bact) PQS signaling(J Bact) Letters read on TWiM 210 TWiM Listener survey Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv  

The TWiM team reveals how ribosome modification resuscitates bacterial persister cells, and explain how a phage tail fiber protein exploits rotation of flagella to move towards the cell membrane. Become a patron of TWiM. Links for this episode: Ribosome modification resuscitates persister cells (Environ Micro) Flagellotrophic phage targets host with tail fiber (Mol Micro) Hydrodynamics of phage migration along flagella (Phys Rev Fluids) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv  

Hosts: Vincent Racaniello, Michele Swanson and Michael Schmidt Guests: Deanna Beatty, Mark Hay, Gina Lewin, Frank Stewart, and Marvin Whiteley At Georgia Tech, members and trainees of the Center for Microbial Dynamics and Infection discuss the identification of pathogen essential genes during coinfections, and how coral management can improve coral defenses against pathogens. Become a patron of TWiM. Links for this episode: Center for Microbial Dynamics and Infection Pathogen essential genes during coinfection (PNAS) Managing coral protects from pathogens (Sci Adv) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv  

From ASM Microbe 2019 in San Francisco, Vincent speaks with Victoria McGovern, Carl Nathan, and Dan Portnoy about advancing human health through innovative collaborations. Host: Vincent Racaniello Guests: Victoria McGovern, Carl Nathan, and Dan Portnoy Links for this episode: Getting grants (Virulence) Nitric oxide synthase protects against tuberculosis (PNAS) Actin filaments and Listeria monocytogenes (J Cell Biol) Become a Patron of TWiM! Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv

The TWiM holobionts pay tribute to Stuart Levy, and reveal the remarkably diverse array of cyclic nucleotides synthesized by bacteria that likely mediate interactions with animal and plant hosts. Become a patron of TWiM. Links for this episode: Stuart Levy, Antibiotic Resistance Researcher, Dies Resistance fighter (The Scientist) Stuart Levy on TWiM 16 Stuart Levy on Meet the Scientist episode 17 Segregation of R factors (Nature) Infectious drug resistance (Sci Am) Spread of antibiotic resistance chickens to humans (Nature) Costs of antimicrobial resistance (Clin Inf Dis) Bacteria synthesize diverse nucleotide signals (Nature) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv

The tetracoccal TWiM team visits Tardigrades on the Moon, and the twelve year quest to isolate an archaeon that provides insights into the emergence of the first eukaryotic cell. Links for this episode: Tardigrades on the moon (Mashable) Meet the Tardigrade (WaPo) Archaeon at prokaryote-eukaryote interface (bioRxiv) Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a Patron of TWiM! Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv

Host: Vincent Racaniello Guests: Nicholas Arpaia and Tal Danino Vincent meets up with Nick and Tal to explain how they engineered E. coli to lyse within tumors and deliver an antibody that causes tumor regression in mice. Links for this episode: Programmable bacteria induce tumor immunity (Nat Med) Synchronized cycles of bacterial lysis (Nature) TWiM Listener survey Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a Patron of TWiM! Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv

The TWiM team reveals thousands of small novel genes in the human microbiome, and a mutualistic symbiosis between marine protists covered with magnetosome-containing bacteria. Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt Links for this episode Thousands of small novel genesin human microbiome (Cell) A magnetotactic consortiumunder the sea (Nat Micro) Image credit Letters readon TWiM 203 Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv Become a Patron of TWiM!

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt Guest: Julie Wolf Julie joins the TWiM team to reveal how microbiome and gut anatomy of a wood-feeding beetle promotes lignocellulose deconstruction, and bacteria that degrade PET plastic. How wood-feeding beetles deconstruct lignocellulose (PNAS) Meet the Microbiologist hosted by Julie Wolf Bacteria that degrade PET plastic (Micr Res Ann) Microbiology resource of the month (ASM) Morgan Vague’s TED talk Pacific garbage patch (Pacific Beach Coal) NOAA marine debris program National Geographic’s Planet or Plastic Campaign  Image credit Letters read on TWiM 202 Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a Patron of TWiM! Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv

Mark Martin joins Vincent and Michael to present compelling papers suitable for teaching microbiology to undergraduate students. Become a patron of TWiM. Links for this episode: Paradigm shifts, paradigm drifts (pdf) Introducing THOR (mBio) Engineering bacteriophages to treat mycobacterial infection (Nat Med) Biofilms by Colter (Int Microbiol) Life in a world without microbes (PLoS Biol) Reduction of cholera in Bangladeshi villages (PNAS) Placenta goes viral (PLoS Biol) #OMG (jpg) #OMG illustration by Sarah Adkins Microbe-Biologist button (jpg) Microbial Centricity button (jpg) Microbial Eyes button (jpg) Micronauts button (jpg) Send your microbiology questions and comments to twim@microbe.tv Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Vincent, Michele, and Michael travel to San Diego to reminisce with Elio about his career, his work in microbiology, and his love for microbes and mushrooms. VIDEO VERSION AVAILABLE: https://www.youtube.com/watch?v=Menlo1YvPko Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email.Get the entire ASM Podcast Network via our Microbeworld app. Become a patronof TWiM. Links for this episode Elio’s profile Elio’s memoirs Elio’s first paper, 1952 (J Bact) In the Company of Mushrooms Small Things Considered TWiM Listener survey Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv  

From ASM Microbe 2019, the Microbials meet up with Susanna L. Harris and Alex Politis to talk about mental health in graduate school and NIH peer review. Hosts: Vincent Racaniello, Michele Swansonand Michael Schmidt Guests: Susanna L. Harrisand Alex Politis Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app. Become a patron of TWiM Links for this episode PhD Balance Susanna’s video(Vimeo) NIH Center for Scientific Review TWiM Listener survey Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv  

The TWiM team presents an extracellular bacterium associated with Paramecium, and induction of antiviral immunity by a bacteriophage that prevents bacterial clearance. Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a Patron of TWiM! Bacteria on the outside of paramecia (ISME) Phage trigger antiviral immunity (Science) Image credit Letters read on TWiM 198 Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv

The Microbials reveal how a chemosynthetic symbiont stores energy for its marine flatworm host, and extraction of nutrients from host cells by E. coli injectisome components. Become a patron of TWiM. Links for this episode: Take the TWiM listener survey Bacteria store energy for gutless worms (PNAS) Paracatenula on TWiM #21 E. coli extracts nutrients from host cells (Cell) Image credit Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv

The Microbials discuss how ambrosia beetles utilize ethanol to farm fungi, and how cleaved cochlin protein sequesters bacteria in the inner ear to preserve hearing function. Links for this episode: Ambrosia beetles, ethanol, and farmed fungi (PNAS) Cleaved cochlin protects the inner ear (Cell Host Microbe) Importance of flossing (ADA) Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a Patron of TWiM! Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv

Michael and Vincent discuss the finding of immunity to Cas9 protein in humans, and a potential role for an oral bacterium in Alzheimer’s disease. Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email.Get the entire ASM Podcast Network via our Microbeworld app. Become a patron of TWiM. Links for this episode Immunity to Cas9 protein in humans (Nat Med) P. gingivalis and Alzheimer’s disease (Science) Clinical trial of COR388 in AD patients (clinicaltrials.gov) TWiM Listener survey Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv