This Week In Microbiology

Vincent meets up with Catharine Bosio, Michael Merchlinsky, and Shilpa Gadwal at the ASM Biothreats meeting to talk about careers for scientists outside of the ivory tower. Become a patron of TWiM. Links for this episode: ASM Biothreats 2017 Rocky Mountain Laboratory BARDA  

The TWiMers discuss how changes in domestic laundering affect the removal of microorganisms, and assembly of a nucleus-like structure during viral replication in bacteria. Hosts:  Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a patron of TWiM. Links for this episode Laundry hygiene (J Appl Micro) Nucleus-like structure in infected bacteria (Science) Video of nucleus assembly in bacteria (YouTube) Image credit Letters read on TWiM 144 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twim Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 

Vincent, Michael, and Michele explain the use of an electrochemical gradient to eliminate bacterial biofilms, and how phage susceptibility can be transferred by exchange of receptor proteins. Hosts:  Vincent Racaniello, Michael Schmidt, and Michele Swanson. Right click to download TWiM#143 (32 MB .mp3, 66 minutes). Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a patron of TWiM. Links for this episode Electrochemical scaffold to eliminate persistent biofilms (npj Biofilms Microbiomes) Experimental setup for electrochemical treatment of biofilm (pdf, from article) Acquisition of phage sensitivity by transfer of cell receptors (Cell) Image credit Letters read on TWiM 143 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for ou

Vincent, Elio and Michele wind up a year of microbial podcasts with a story about the lack of resistance to a crop antifungal compound, and how a bacterium uses a molecular caliper to measure membrane thickness. Hosts:  Vincent Racaniello, Elio Schaechter, and Michele Swanson. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode Phenylpyrroles: Nearly no resistance (Front Micro) Membrane-thickness caliper (J Bact) Letters read on TWiM 142 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv 

Jennifer joins Vincent, Elio, and Michael to talk about the work of her laboratory on how a respiratory virus enhances bacterial growth by dysregulating nutritional immunity. Hosts:  Vincent Racaniello, Elio Schaechter, and Michael Schmidt. Guest: Jennifer Bomberger Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode Virus dysregulation of nutritional immunity (PNAS) Podcast article mentioned by Michael Compromised defenses (PLoS Path) This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This show is sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. D

Host: Vincent Racaniello Guests: Marie Antonioli, Bryan Hansen, Forrest Jessop, Kyle Shifflet and Jim Striebel At the Hamilton, Montana Performing Arts Center, Vincent speaks with three local high school graduates and two high school teachers about how Rocky Mountain Laboratories influenced school science programs and opened up career opportunities.   Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a Patron of TWiM! Links for this episode Poster of this event (jpg) Rocky Mountain Laboratories Hamilton, MT high school Video of this episode on YouTube This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MI

The TWiM team discusses microbial DNA found on ATM machines in New York City, and how hydraulic fracturing, or fracking, alters microbial ecosystems deep in the Earth. Hosts:  Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode Microbial DNA on ATM machines in NYC (mSphere) NYC OpenData Altering deep microbial ecosystems by fracking (Nat Micro) Marcellus Shale Energy and Environment Laboratory Chemicals used for fracking (FracFocus) Marcellus and Utica shale formation map Consequences of fracking (GasBuddy) Image credit This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curio

The TWiM team brings you a bacterium from a Colorado field site that grows on uranium, and copper resistance in the emerging pathogen Acinetobacter baumannii. Hosts:  Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode Kavli Microbiome Ideas Challenge Uranium-respiring bacterium from a field site (PLoS One) Acid mine drainage (Wikipedia) Copper resistance of Acinetobacter baumannii ASM Grant Writing Online Course TWiM #132: Bacteria learn long division Image credit This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​

Highlights of the Recent Advances in Microbial Control meeting in San Diego, and expansion of a gut pathogen by virulence factors that stimulate aerobic respiration. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode Fred Neidhardt obituary Recent Advances in Microbial Control Science hero Bill Fenical Virulence factors and aerobic respiration (Science) Image credit Letters read on TWiM 137 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​. This episode is also brought to you by Drobo, a family of safe, ex

Them TWiM team discusses the importance of neutrophils in microbial infections, and evidence that ancient bacteria had two cell walls. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode Conquering neutrophils (PLoS Path) Ancestral outer membrane in firmicutes (eLife ) Were gram positive rods the first bacteria? (Cell) Image credit Letters read on TWiM 136 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage

Links for this episode Dysbiosis of microbiome in critical illness (mSphere) Consequences of sewage spill into aquatic environment (App Env Mic) EPA recreational water guidelines (pdf) VRE following sewage spill (Outbreak Radio) FAQ: Human microbiome American gut project British gut project Rob Knight on human microbiome (TED) Rob Knight on TWiM Image credit TWiM 135 Letters This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by u

Design of a synchronously lysing bacterium for delivery of anti-tumor molecules in mice, and hopanoids, the lipids that live forever, brought to you by the four Microbies of TWiM. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode Bacterial lysis for in vivo delivery (Nature) Coley’s toxins (Iowa Orthop J) Hopanoids, stress tolerance, and nutrient storage (Geobiol) Lipids that last forever (STC) Fattening up microbial geological biomarkers (STC) Money spreads infection (Fut Micro) This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use

Insight into the biology of rhinovirus C from cryo-electron microscopy, and a novel antibiotic from a commensal bacterium that grows in the human nose, from the doctors of TWiM. Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode Cryo-EM of viruses and vaccine design (PNAS) Atomic structure of rhinovirus C (PNAS) Opening windows into the cell (STC) Human commensals produce novel antibiotic (Nature) The nose knows (Nature) Letters read on TWiM 133 Image in audio player: Molecular surface of a Human rhinovirus, showing protein spikes. By: Wiki user: Robin S This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely fr

Vincent, Elio, and Michele present cell division by longitudinal scission in an insect symbiont, and thermally activated charge transport in microbial nanowires. Hosts: Vincent Racaniello, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode Cell division by longitudinal scission (mBio) Bacterium learns long division (STC) Charge transport by microbial nanowires (Sci Rep) Mechanism of nanowire conductance (Nat Comm) Using nature to grow batteries (TED) SEM of Y-shaped S. poulsonii (above) - Image credit Extracellular electron transport (below) - image credit This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curio

Hosts: Vincent Racaniello and Michael Schmidt Michael and Vincent present Spotlights, brief reviews of classic papers in the Journal of Bacteriology, and explain how a single bacterial species can reverse autism-like social deficits in the offspring of obese mice.   Links for this episode Protein secretion in E. coli (J Bacteriol) Plague pathogenesis (J Bacteriol) Reversal of diet induced social defects (Cell) Letters read on TWiM 131 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv

Filmed live in Boston, MA at Microbe 2016, David S. Schneider and Vanessa Sperandio talk about their work on regulation of bacterial virulence in the gut by bacterial adrenergic sensors, and the physiological mechanisms that make us ill and that help us recover.

The arrival in the US of plasmid-mediated resistance to colistin antibiotics, a last line of defense against many gram-negative bacilli, and a quorum sensing system in a eukaryote are topics of this episode hosted by Vincent, Michael, and Michele. Image: Etest used to determine the minimum inhibitory concentration of an antibiotic for a particular bacterium. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.  Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode E. coli with mcr-1 on a plasmid in the US (AAC) Emergence of plasmid mediated colistin resistance in China (The Lancet) Major breach in last line of defense (The Lancet) Resistance plasmid families in Enterobacteriaceae (AAC) EUCAST MIC breakpoints (ClinCalc) Role of ASM in microbial resistance one, two (bLogphase) Quorum sensing in fungi (Cell Host Microbe) Image credit Letters read on TWiM 129 This episode is brought to you by Curios

A eukaryote without a mitochondrion, and using a phage enzyme to eliminate intracellular bacteria are two topics discussed by the TWiMers on this episode. Image (right): An entry in the ASM Agar Art Contest which bears an uncanny resemblance to one of the TWiM hosts. Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode Copper and Michael Schmidt in the news (The Scientist) Fair Pay for Postdocs (Huff Post) National Microbiome Initiative (White House) The shrinking mitochondrion (The Scientist) Eukaryote without a mitochondrion (Curr Biol) Why have organelles retained genomes? (Cell Sys) Bugs as drugs (Amer Acad Micro) Phage encoded lysin eliminates intracellular bacteria (eLife) This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from

The TWiM team explores microbes in snowblower vents on the ocean floor, and cleavage of antibody molecules by a Mycoplasma protease. Image (right): Photograph of the ‘Subway’ snowblower vent on the sea floor at Axial Seamount, Juan de Fuca Ridge. Visible are white ‘snow’ in the vent and orange floc on the seafloor. Credit: Canadian Scientific Submersible Facility and the University of Washington Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode Happy Birthday, Elio! In the Company of Microbes Snowblower vents (Front Micro) Deep-sea snowblower vents video (YouTube) Visions 11 cruise photos Mycoplasma capture and cleave IgG (PNAS) Snowblower image (large) Letters read on TWiM 127 This episode is sponsored by ASM Agar Art Contest and ASM Grant Writing Course Send your microbiology questions and comments (email or mp3 file)

The microbiome of hibernating bears, and zebrafish as a model for bacterial sepsis feature in this animal-centric episode of TWiM hosted by Vincent, Michael, and Michele. Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode Microbiome of hibernating brown bear and energy metabolism (Cell Rep) Ten animals that hibernate (Cons Inst) Zebrafish model of sepsis (mSphere) Image credit Letters read on TWiM 126 This episode is sponsored by ASM Agar Art Contest and ASM Microbe 2016 Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.