Journal Of Clinical Oncology (jco) Podcast

This podcast This JCO Podcast provides observations and commentary on the JCO article, "A European collaborative study of natural history, outcomes and validation of prognostic and response criteria in IgM related AL amyloidosis."

This podcast puts into context the findings from Hart and colleagues, highlighting the clinical care and research implications.  

In this podcast, the article by Meropol et al. describing a randomized trial of a web-based educational tool versus a standard text-based resource is analyzed and placed in context of other challenges that limit the enrollment of adult cancer patients in contemporary clinical trials.

A study by Ramsey and colleagues suggests that extreme financial distress as manifested by personal bankruptcy might be associated with worse mortality in cancer patients. Long-term solutions have to focus on policy shifts involving how we set prices for drugs and how we design health insurance, but for more immediate solutions interventions have to focus on the oncologist and patient.

The Ki-67 proliferation index improves the prognostic value of the MIPI score.

Ethnicity’s impact on diagnosis and survival of T-cell lymphoma

This podcast reviews the International Bladder Cancer Group’s recommendations regarding definitions and endpoints for the development of non-muscle-invasive bladder cancer clinical trials.

An update on clinical trials that have included children with hepatocellular carcinoma

Discussion of a phase I trial of the checkpoint inhibitor atezolizumab in metastatic renal carcinoma.

This podcast reviews the accompanying article to provide the audience an understanding of the data and rationale to support updating the INRC primary site response criteria.

This podcast provides commentary on the importance of symptom assessment in Polycythemia Vera, and how this may impact therapeutic decision-making.

This podcast describes the evolving role of Gallium-68 somatostatin-receptor PET imaging in the evaluation of patients with well-differentiated neuroendocrine tumors, and compares the diagnostic sensitivity of this imaging modality to conventional scans.

Summarize the paper by Asselin et al and review the risks of therapy-related cardiomyopathy and evidence supporting dexrazoxane use in pediatric oncology.

Recent findings represent an important and exciting step in applying the rapid advance of sequencing technologies to generate molecularly-driven approaches towards the detection of gynecologic malignancies.  More work is needed to better define and validate where such an approach might add most meaningfully in the search for effective methods of ovarian and endometrial cancer detection and diagnosis.

This podcast discusses the study by Hennink and colleagues regarding their randomized controlled trial of a 3-year versus 6-year interval for screening colonoscopies in individuals with a family history of colorectal cancer.

The randomized placebo controlled trial of progesterone receptor blockade showed no difference in survival, finally answering the question about hormonal therapy in this disease and raising new questions about how to move forward quickly.