Naturejobs Podcast

Isabelle Mansuy’s neuroepigenetics lab researches the impact of life experiences and environmental factors on mental health, exploring if these impacts can be passed on to descendants.Epigenetic inheritance, she says, is not confined to diets and exposure of factors such as like endocrine disruptors or environmental pollutants. All of these can modify our body and have effects in our offspring. But Mansuy, who is based at the University of Zurich and Swiss Federal Institute of Technology in Zurich, Switzerland, also asks if trauma modifies not only our brains, but also our reproductive systems.There is still a lot of work needed, she adds, but the possibility that depression or borderline personality disorder might be something inherited from parents would be important for patients and clinicians to understand.Mansuy’s lab seeks to expose animals prenatally or after birth to conditions which mimic human stress. Her collaborators also provide access to blood and saliva samples from people exposed to childhood

Deep brain stimulation (DBS) is an experimental treatment strategy which uses an implanted device to help patients with severe depression who have reached a point where no other treatment works.But despite her involvement in the DBS collaboration, which involves neuroscientists, neurosurgeons, electrophysiologists, engineers and computer scientists, neurologist Helen Mayberg does not see it as a long-term solution.“I hope I live long enough to see that people won't require a hole in their brain and a device implanted in this way,” she says . “I often have a nightmare with my tombstone that kind of reads like, what did she think she was doing?”Mayberg, director of the Nash Family Center for Advanced Circuit Therapeutics at the Icahn School of Medicine at Mount Sinai in New York City, introduces Brandy as a typical patient, who says of her condition; “It kind of holds me down, and it takes so much effort to do anything, or to experience anything, and there’s always that cost of, kind of reminds me of like scar

Thomas Hummel, who researches smell and taste disorders at the Technical University of Dresden in Germany, describes international efforts to help patients who have lost their sense of smell, perhaps as a result of COVID-19, head trauma, chronic rhinosinusitis, and neurodegenerative diseases.Hummel points to the development of cochlear implants to help patients with hearing loss. “There could be similar implants inside the nasal cavity connected to the olfactory bulb, eliciting a pattern that might make sense to the brain,” he says.Describing his career path, Hummel, who is also a medical doctor, says unlike some other clinical research areas, his is more heavily dependent on international collaborations. “When you work in cardiovascular diseases you just look around the corner and there’s somebody who works on cardiovascular disorders. In the sense of smell it is different. You look around the corner, and there’s nobody.” Hosted on Acast. See acast.com/privacy for more information.

In 2020 the forced isolation of pandemic-related lockdowns led many of us to attend virtual fitness classes and undertake home baking projects. Chantel Prat wondered why she wasn’t interested in taking part. “I couldn’t help but notice and be frustrated by the fact that my brain was responding to the pandemic in a way that seemed very different from the people around me,” she says.At the time Prat was writing her book The Neuroscience of You. Published in 2022, it explores how different brains make sense of the world. “I've always been interested in the relationship between the mind and the brain, at the level of the individual, not how do brains work in general,” she says.“Right now I feel like we’re living through a great social paradox,” she adds. “People are discussing the importance of having diverse minds and brains and decision-making spaces. But yet, we don’t seem to be getting any better at talking through our differences.”To illustrate her point, Prat, who is based at the University of Washingt

A child neurologist treating Christin Godale’s epilepsy was so impressed with his young patient’s interest in the brain he gave her some of his textbooks to read during an extended stay in hospital.“He said I should consider a career in neuroscience. That moment really changed my life,” says Godale, who followed his advice and went on to research epilepsy for her PhD at the University of Cincinnati, Ohio.Godale describes how at one point she was experiencing up to 30 seizures a day and spent periods in a coma, severely curtailing her quality of life, childhood friendships, and graduate school experiences.“I’ve developed some habits to combat these cognitive impairments that I experience,” she says. “I find myself writing down everything that I’m learning in a lecture and hearing at a meeting.”When the pandemic struck in March 2020 and labs shut down, Godale embarked on patient advoacy work and science communication via the Society for Neuroscience’s early career policy ambassadors program.She lobbied Congress

In his 2022 book Zero to Birth, How the Human Brain is Built, developmental neurobiologist William Harris includes ice hockey analogies to describe how the body’s most complicated organ develops in the womb, drawing on a 40-year career studying fruit fly, salamander, frog and fish embryos.Harris, professor emeritus at Cambridge University, UK, played the sport growing up in Canada and is now a coach. “A coach will have tryouts and select the best players for different positions,” he says. “The brain does the same thing. Maybe two neurons try out for every position, one makes it that’s a little bit better at communicating, and the other one doesn’t, going through a process called apoptosis. The survivors have to last your whole life.”Harris highlights some differences between human and animal brains, (cerebral cortex size, for example, and how newborn babies are hard wired to understand and develop speech). Writing the book, he believes, made him respect human and animal brains even more. “Probably our br

An applied goal of Pieter Roelfsema’s lab at the Netherlands Institute for Neuroscience in Amsterdam is to create a visual brain prosthesis aimed at people who have lost their sight.To help achieve this goal, the lab partners with both neurosurgeons and artificial intelligence researchers.“We are knowledgeable about how to put electrodes in the brain,” says Roelfsema, “but we collaborate with experts who know about how to make these electrodes so that they don't damage the brain tissue too much, also with people in artificial intelligence who can take camera images and translate them into brain stimulation patterns.“We also collaborate with neurosurgeons who can inform us how to really make this device and make it something that is going to be feasible for a neurosurgeon to really implant in the brain. That is definitely a very important goal for me, to bring this to a patient.”In episode five of Tales from the Synapse, a podcast series with a focus on brain science, Roelfsema describes how he handles request

Gina Rippon was a paid-up member of the “male-female brain brigade” earlier in her career as a cognitive neuroscientist, but changed tack, she says, after discovering there was not a lot of sound research behind the well-established belief that male and female brains are biologically different.In the fourth episode of this 12-part podcast series Tales from the Synapse, Rippon explores the role of social conditioning to explain why boys and girls might respond differently to pink and blue objects, why girls aged nine describe maths “as a boy thing,” and why the same girls shun games that are aimed at children “who are really, really smart.”Rippon, Professor Emeritus of cognitive neuroimaging at Aston University in Birmingham, UK and author of the 2019 book The Gendered Brain , is also interested in why women continue to be under-represented in science even in countries that purport to be gender-equal.Her forthcoming second book investigates why girls and women on the autism spectrum have histori

After a mostly miserable childhood in the small Israeli village of Tel Aviv (his words), Ori Amir moved to the US, where he gained a PhD in cognitive neuroscience and launched a second career as a stand-up comedian.Amir is now a professor at Pomona College in Claremont, California, where he researches what happens in our neural networks when we are trying to be funny.His interest in this was triggered after realising there were around 20 studies examining brain activity when we are enjoying comedy, he says, but nothing about the creative process involved in being funny. Amir’s research also investigates attempts to use artificial intelligence to generate humour.“I’m afraid that if I make any jokes about artificial intelligence, I will get in trouble in the future. Artificial intelligence would cancel me. So I’m refraining from making any such jokes,” he tells his audience.Amir’s stand-up act also includes anecdotes about life as a PhD student. “It’s going to take seven years, the first five-and-a-half-years t

In the second episode of this 12-part podcast series, Tales of the Synapse, neuroscientist Anil Seth describes his research into consciousness, which he describes as “insurance against falling into a single, disciplinary hole.”Alongside neuroscientists, Seth’s research group at the University of Sussex in Brighton, UK, also includes string theorists, mathematicians and psychologists. The team also collaborates with academics in the arts and humanities.His 2021 book Being You: A New Science of Consciousness. begins by challenging the idea that consciousness is beyond the reach of science, and concludes with a look at consciousness in non-human animals, before asking if artificial intelligence will one day become both sentient and conscious.Seth’s own academic career path demonstrates the many disciplines with an interest in consciousness. He began studying physics but transitioned to psychology, computer science and artificial intelligence, the subject of his PhD at Sussex. He returned there to set u

As a pharmacy student at the University of Wisconsin–Madison, Natasha Mason was struck by the high volume of patients who complained about opiates and antidepressants not working, but at the same time became more and more dependent on them.This observation triggered an interest in the behavioural effects of psychedelic drugs, which took her career in a psychopharmacological direction. She now researches the neural effects of cannabis, both when people are under the influence of the drug, and over the longer term, at Maastricht University in the Netherlands.Mason is also interested in the positive and negative effects of developing a tolerance to cannabis.“Recreational users tend to use cannabis for the relaxing or the euphoric effects. So here, tolerance can be seen as kind of a maladaptive thing. You have to use more of the drug to get the high that you want … This is where addiction dependence can come in,” she says.“But tolerance can be a good thing in regards to the clinical use of this drug. Individuals

How do you learn leadership skills as a researcher, and how well is science served by its current crop of leaders?These are just two of the questions asked of scientific leaders from a range of sectors and backgrounds in this five-part Working Scientist podcast series, all about leadership.In this final episode, Gianpiero Petriglieri focuses on the emotional aspects of leadership — describing it as a love for an idea, and for a group of people whom you’re trying to both protect and advance.Petriglieri, who researches organizational behaviour at INSEAD Business School in Fontainebleau, France, says that being in the physical presence of an effective leader should ideally make you feel calm, clear about priorities and cared for.Julie Gould also talks to Robert Harris, a past president of ORPHEUS, the Organisation for PhD Education in Biomedicine and Health Sciences in the European System; he’s also a research-group leader at the Centre for Molecular Medicine, part of the Karolinska Institute in Solna,

How do you learn leadership skills as a researcher, and how well is science served by its current crop of leaders?These are just two of the questions asked of scientific leaders from a range of sectors and backgrounds in this five-part Working Scientist podcast series, all about leadership.In this penultimate episode, stem cell biologist Fiona Watt tells Julie Gould that one of her leadership mantras is: “There is nothing wrong with being wrong,” and that science is in good shape if it can acknowledge this.Watt is director of EMBO, the European molecular biology organization, based in Heidelberg, Germany.Her leadership positions before joining the organisation in 2022 include leading the Centre for Stem Cells and Regenerative Medicine at King's College London.In this role she was able to indulge an interest in improving scientists’ working environments as part of a redesign project of its labs, offices and core facilities. In 2018 Watt was appointed the first executive chair of Medical Research Coun

How do you learn leadership skills as a researcher, and how well is science served by its current crop of leaders?These are just two of the questions asked of scientific leaders from a range of sectors and backgrounds in this five-part Working Scientist podcast series, all about leadership.In this episode, Hagen Zimer tells Julie Gould about the qualities and skills you need to be a science leader in industry and how he approaches his role as managing director of TRUMPF Laser, a global company based in Schramberg, Germany, that manufactures lasers and laser-processing machine tools.Zimer says that effective leaders are good listeners who display high levels of empathy, so that they can understand individual colleagues’ fears and concerns. They also need to be authentic, he adds. If not, teams will not believe what they are being told.Zimer says that early-career researchers with leadership ambitions should ask themselves whether they see themselves taking the lead role in a play. “If you are in the leading po

How do you learn leadership skills as a researcher, and how well is science served by its current crop of leaders?These are just two of the questions asked of scientific leaders from a range of different sectors and backgrounds in this five-part Working Scientist podcast series all about leadership.In this episode, Spanish neuroscience and mental health researcher Gemma Modinos talks about her own leadership journey as a group leader at King’s College London and former chair of the Young Academy Europe.Modinos compares “command and control” leadership styles with more collaborative approaches and says aspiring science leaders should not neglect leadership training as part of their career development.Learning how to say no effectively and allocating time to meet looming deadlines is another key skill, she tells Julie Gould.But should all early career researchers nurture leadership ambitions? No, says Modinos. “Not everyone has to strive to become a PI, or to be involved in chairing an organization, o

How do you learn leadership skills as a researcher, and how well is science served by its current crop of leaders?These are just two of the questions asked of scientific leaders from a range of different sectors and backgrounds in this five-part Working Scientist podcast series.In this episode, Charu Kaushic, a research group leader at McMaster University in Hamilton, Canada, says that leadership is more than just exercising power, competence and confidence, it is also about wanting to do good.Kaushic, who is also scientific director of the Canadian Institute of Infection and Immunity in Ottawa, describes how a better gender balance in science’s senior ranks will lead to a more consensual style of leading teams.She also offers some insights into how she honed her personal leadership style and how she adapts it for her different roles. She also talks about some leadership tasks that she still finds challenging. Hosted on Acast. See acast.com/privacy for more information.

Alongside the stresses of adapting to a new country and settling into a new lab, scientists who have made the move abroad since 2020 often face extra barriers as a result of the COVID-19 pandemic.These include rescinded job offers, postponed start dates, burdensome vaccine paperwork and long and lonely stints in quarantine hotels.Neuroscientist Jen Lewendon tells Adam Levy about her move from the United Kingdom to Hong Kong via Thailand to begin a postdoc at the Hong Kong Polytechnic University.“The obvious disparity between the way COVID is being handled in the West and the way COVID is often being handled in Asia makes splitting life between two places very difficult,” she says.Astrophysicist Katie Mack was on an extended visit to the Perimeter Institute for Theoretical Physics in Waterloo, Canada, when the 2020 lockdown took effect, preventing her return North Carolina State University in Raleigh.The experience made her re-assess her career priorities.This is the final episode of a six-part Working Scienti

Kelsey Byers outlines some of the things disabled scientists should look out when they are looking to move labs, both at home and abroad. Byers, an evolutionary chemical ecologist who was diagnosed with Ehlers-Danlos Syndrome in her 20s and is now a group leader at the John Innes Institute, a plant and microbial research institute in Norwich, UK, also offers advice on how to talk about disability to potential employers.She is joined by Logan Gin, a STEM education researcher at Brown University in Providence. Gin, who has diastrophic dysplasia dwarfism, describes how his research is helping to identify solutions to support students with disabilities.Every institution should be able to support faculty members and scholars with disabilities, adds Siobhán Mattison, an evolutionary anthropologist at the University of New Mexico in Albuquerque, who has myasthenia gravis.Kim Gerecke, a behavioural neuroscientist at Randolph Macon College in Ashland, Virginia, talks about the measures she has been able to take to sup

After completing a PhD in cancer biology at the University of Chicago, Illinois, in 2017, Tim Fessenden moved to a laboratory at the Massachusetts Institute of Technology in Cambridge to focus on immunology.Fessenden, who is now an editor at the Journal of Cell Biology in New York City, says that alongside adjusting to a new lab culture, he needed to learn new techniques, adding: “I am a lifelong student, someone who always wants to be the dumbest person in the room.”Fessenden is joined by physician-scientist Ken Kosik, and Jennifer Pursley, a particle physicist-turned-medical physicist.Kosik’s neuroscience research and collaborations are influenced by his close working proximity to physical scientists. In 2004, he quit a tenured post at Harvard University’s Longwood campus in Boston, Massachusetts, moving to a more multi-disciplinary location at the University of California, Santa Barbara.Pursley, who left the Fermi National Accelerator Laboratory at the University of Wisconsin–Madison in Batavia,

In the third episode of this six-part Working Scientist podcast series about moving labs, three researchers who moved abroad for work describe how they handled the challenges it brought, including language barriers, cultural differences and experiences of racism.Sara Suliman, an immunology researcher and assistant professor at the University of California, San Francisco, shares her experiences of labs in South Africa, Canada and the United States as a scientist from the African diaspora. She was born in Sudan.Ali Bermani, a PhD student who moved from Iran in 2019 to study electrical engineering at the University of Gävle in Sweden, talks about how he learnt to decipher feedback from Swedish colleagues, and about their calm approach to work compared to previous work experiences.And Keshun Zhang, a psychologist at Qingdao University in China, explains why he returned to that country after completing his PhD at the University of Konstanz, Germany, and why he now urges his students and colleagues to work and stud